Term
| What is released within seconds from mast cells? |
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Definition
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Term
| Immature blood borne phagocyte |
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Definition
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Term
| Mature phagocyte - in tissue |
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Definition
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Term
| Monocytes are produced in? |
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Definition
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Term
| How long does it take for Macrophages to get to inflammation cite? |
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Definition
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Term
| What cells do macrophages replace at inflammation cite? |
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Definition
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Term
| Macrophage activation produces what affects? (4) |
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Definition
| increased size of plasma membrane, increased glucose metab., increased lysosomes, increased secretory products |
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Term
| WBC that is primary defense against parasites |
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Definition
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Term
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Definition
| Never Let Monkeys Eat Bananas |
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Term
| What cells recognize & eliminate cells infected with virus, abnormal host cells, & some cancers? |
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Definition
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Term
| What has two thumbs and wishes Dr. Walsh would slow down a bit? |
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Definition
| Look at Buck pointing to himself with both pollical |
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Term
| What cellular component contributes to clotting |
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Definition
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Term
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Definition
| Fragments of this form platelets |
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Term
| Process by which cells ingest and dispose of foreign material |
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Definition
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Term
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Definition
| Neutrophils & Macrophages |
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Term
| Produce adhesion molecules |
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Definition
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Term
| Process of leukocytes adhering to endothelial cells |
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Definition
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Term
| Process of cells emigrating through endothelial junctions |
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Definition
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Term
| Steps of phagocytosis (5) |
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Definition
| 1. Opsonizaton, recognition, & adherance, 2. Engulfment, 3. Phagosome formation, 4. fusion with lysosomal granules, 5. Destruction of target |
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Term
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Definition
| the term "cytokine" has been used to refer to the immunomodulating agents, such as interleukins and interferons, small cell signaling proteins |
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Term
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Definition
| Interleukins & Interferons, also Tumor Necrosis Factor (TNF-alpha) |
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Term
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Definition
| Cytokine - protects against viral infection |
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Term
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Definition
| Cytokine - produces by macrophages & lymphocytes in response to patho, can be stimulated by other inflam. |
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Term
| Tumor Necrosis Factor alpha |
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Definition
| Cytokine - secreted by macro. In response to Toll-like receptor recognition, fever through endogenous pyrogens |
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Term
| Cytokine causing muscle wasting (cachexia) & intervascular thrombosis |
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Definition
| Tumor Necrosis Factor - alpha |
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Term
| Family of low molecular weight peptides that induce leukocyte chemotaxis |
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Definition
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Term
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Definition
| The characteristic movement or orientation of an organism or cell along a chemical concentration gradient either toward or away from the chemical stimulus |
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Term
| movement of cell along chemical gradient |
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Definition
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Term
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Definition
| produces by several types of cells and promote WBC chemotaxis |
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Term
| Acute inflammation - local manifestations |
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Definition
| swelling, pain, heat, redness |
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Term
| Vascular changes and leakage of circulation components into tissue occur with? |
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Definition
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Term
| Leaks from injury or wound |
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Definition
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Term
| Thin watery exudate - blister |
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Definition
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Term
| Thick and clotted exudate |
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Definition
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Term
| Exudate that is accumulation of WBC; common in bacterial infection |
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Definition
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Term
| Exudate with erythrocytes present |
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Definition
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Term
| Acute inflammation systemic manifestation involving pyrogens |
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Definition
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Term
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Definition
| endogenous pyrogents and exogenous pyrogents (from patho.) act directly on hypothalamus |
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Term
| What gland is affected by endogenous and exogenous pyrogens? What is result? |
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Definition
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Term
| Acute inflammation systemic manifestation involving increased number of circulating WBC's |
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Definition
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Term
| Leukocytosis is a ________ shift? |
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Definition
| Left shift: increase in immature cells ("bands") compared to mature cells |
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Term
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Definition
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Term
| Acute inflammation systemic manifestation involving increased production of proteings |
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Definition
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Term
| Plasma Protein Synthesis products (3) |
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Definition
| C-reactive protein (CRP), fibrinogen, plasminogen |
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Term
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Definition
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Term
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Definition
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Term
| Type of healing involving sealing the wound |
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Definition
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Term
| Type of healing involving shrinking the wound |
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Definition
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Term
| Restores tensile strength to damaged tissue; in scar |
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Definition
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Term
| Injured tissue returns to original structue and function |
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Definition
| Resolution AKA Regeneration |
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Term
| Heals under conditions of minimal tissue loss |
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Definition
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Term
| Healing requires more tissue replacement, e.g. an open wound |
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Definition
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Term
| Phase of healing where fibrin clot replaced by normal tissue |
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Definition
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Term
| How long before healing reconstructive phase begins |
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Definition
| 3-4 days and continues up to 2 weeks |
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Term
| Reconstructive phase compnents (6 from ppt slide 43) |
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Definition
| 1. Granulation tissue, 2. Fibroblast proliferation, 3. Collagen synthesis, 4. Epithelialization, 5. Wound contraction, 6. Cellular differentiation |
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Term
| Maturation phase components |
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Definition
| 1. Continue collagent matrix assembly, 2. Tissue regeneration, 3. Wound contraction, 4. begin post injury process up to 2 years., 5 continual cell differentiation, 6. Avascular scar tissue is remodeled |
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Term
| What is difference between Reconstructive and Maturation phases of healing? |
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Definition
| Recons. Phase (healing begins) starts after 3-4 days of injury till 2 wks. While Matur. Phase (remodeling occurs) starts after several wks. And can go till 2 yrs. |
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Term
| When wound won't heal properly it is? |
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Definition
| Dysfunctional Wound Healing |
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Term
| Dysfunctional healing with impaired collagen synthesis |
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Definition
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Term
|
Definition
| raised scar extending beyond wound margins; impaired collagen synthesis; likely to reoccur if surgically removed |
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Term
| Dysfunctional healing with raised area within wound margin - regresses over time |
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Definition
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Term
| Dysfunctional healing caused by suppressing with anti inflammatory steroid, hypoxemia, radiation or nutritional deficits |
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Definition
| Impaired epithelialization |
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Term
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Definition
| Dysfunctional Wound Healing - wound opens from infection, broken sutures, obesity increases risk |
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Term
| What type of solution should be used to cleanse wound to promote epithelialization? |
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Definition
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Term
| What conditions in older adults is likely to impair inflammation? |
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Definition
| Diabetes, cardiovascular disease, etc . . . (ppt slide 48) |
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Term
| What population would see healing response diminished due to lower skin regen. Ability? |
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Definition
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Term
| What population has more common infections? |
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Definition
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