Term
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Definition
| made in mastcells and basophils. Catalyzed by L-histidine decarboxylase from Histidine. |
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Term
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Definition
| N-methyl transferase, diamine oxidase, 5' phosphoribosyl transferase to imidazole acetic acid. |
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Term
| h1 vs h2 rec effects of stimulation |
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Definition
| H1= bronchoconst, vasodil, exudation H2= acid production in gut |
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Term
| Histamine effect on respiratory system? |
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Definition
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Term
| Histamine effect on Cardiovascular system? |
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Definition
| vasodilation, endothelial cell contraction=exudation |
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Term
| SE's of 1st gen H1 antags that are used as other therapeutic uses. |
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Definition
| can cause sedation-anticholinergic effect (sleep aid) and antiemitic (N/V treatment), also local anesthetic (prometh) |
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Term
| alternative places for histamine besides mast cells |
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Definition
| neurotansm. In brain, found in fundus of stomach-acid secretion |
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Term
| alternate release trigger of hist. other than mast cells |
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Definition
| cytotoxic agents (venom) and various drugs (ex: morphine) |
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Term
| Beta agonist affect on histamine release? |
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Definition
| can inhibit antigen induced hist. release |
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Term
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Definition
| Ca release activated channels: in mast cell steps of degranulation, triggered by bunching of FceR's |
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Term
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Definition
| Gq GPCR, contracts smooth muscle, causes NO release=vasodilation |
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Term
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Definition
| Gs GPCR, in vascular SM causes relaxation (vasodil) |
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Term
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Definition
| in CNS, autoreceptor w hist as neurotransmitter |
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Term
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Definition
| on baso's, mast cells and eos's= histamine-induced chemotaxis |
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Term
| Histamin effects on heart |
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Definition
| moderate incr. in rate and force of contraction (H2 incr SA conduction, reflex tachy from vasodil) |
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Definition
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Definition
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Definition
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Definition
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Definition
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Definition
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| reason why 2nd gen antihist don’t have as bad SE's |
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Definition
| decreased lipid sol, and efflux from CNS by Pgp |
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Term
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Definition
| gastrin released and activates G(CCK-B) rec: 1) in ECL cell, this stim hist release to H2 rec on Parietal cell=camp= acid secr. 2) on parietal cell, activates acid secretion directly |
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Term
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Definition
| accum in stomach b/c protonated in acid, irrev inhibits K/H antiporter, has S that reacts covalently w cystein in binding pocket (S-S bridge) |
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Term
| What secretes acid in stomach: |
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Definition
| K+/H+ antiporter in parietal cell, it is active so needs ATP |
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Term
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Definition
| NaHCO3, Al(OH)3, Mg(OH)2 moderate = CaCO3 |
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Term
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Definition
| OTC antacid w foaming action that helps protect GERD |
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Term
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Definition
| mucosal protective agent- pg E1 derivative, enhances mucus and HCO3 secretion |
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Term
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Definition
| D2 antag= incr AcH release=incr GI motility and antiemetic effects |
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Term
| Nerves that go from GI to Brain |
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Definition
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Term
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Definition
| 5HT3 anatag= decr AcH from neurons in GI, Treats IBS+diarrhea in women, blocks afferent pain and decr motility |
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Term
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Definition
| stim peristalsis (ECL cell stim)= opens ion channels to gut to draw in H2O |
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Term
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Definition
| hydrophobic mass that draws H2O in and distends GI= incr is peristalsis |
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Term
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Definition
| surfactants or lubricants to reduce fecal impaction and make BM easier |
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Term
| MOA (2) of Anti-diarrheals |
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Definition
| slow peristalsis to incr H2O and electrolyte reabs or adsorb potential toxins and water |
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Term
| Opiates for antidiarrheal |
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Definition
| no analgesic effect, bind in GI and decr peristalsis |
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Term
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Definition
| kaloin+pectin= abs toxins and reduces peristalsis |
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Term
| 5HT3 antags and antiemesis |
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Definition
| block activity in CTZ from vagal afferents from stomach and GI |
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Term
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Definition
| incr activity of osteoblasts, decr -clasts |
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Term
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Definition
| (neg regulator of Ca) secreted by thyroid, inhib osteoclasts, incr Ca and PO4 loss in urine |
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Term
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Definition
| 1,25 dihydroxy Vit D3= incr Ca and PO4 abs from GI (TrpV6), inc Ca/PO4 reabs, feedback inhibition of PTH |
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Term
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Definition
| mimic of inorganic P, incorporates into bone matrix, inhib osteoclast formation of cholesterol(FPPS)=decr activity--need to take 30 min prior to meal and remail upright for 30 min |
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Term
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Definition
| PTH from e.coli dosed SC with Ca and Vit D= stim osteoblast activity= stim bone formation |
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Term
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Definition
| binds CaR's on parathyroid to inhib PTH release |
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Term
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Definition
| hydroxyapatite (Ca Po4 OH) crystal |
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Term
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Definition
| maintains Ca conc.: incr Ca reabsorption fromcollecting tubules, Ca resorption from bone, inc Po4 loss in urine, inc Vit d3 prod in kidney, |
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Term
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Definition
| receptor on GI brush border cells made in response to Vit D3, Ca ion channel for abs |
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Term
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Definition
| uncontrolled osteoclast resorption and bad bone formation: leads to bone pain, bone deformities, loss of hearing(hyperCa), may be cause by virus |
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Term
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Definition
| more osteoclast act, decreased osteoblast=low bone mass |
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Term
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Definition
| from osteoperosis, ventral compression of vert= hunched over back |
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Term
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Definition
| Vit D deficiency= bone deformities and hypocalcemia |
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Term
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Definition
| need a N to anchor to receptor better |
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