Term
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Definition
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Term
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Definition
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Term
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Definition
Cholestyramine
Colestipol
Colesevelam |
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Term
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Definition
Atorvastatin
Pravastatin
Lovastatin |
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Term
What are Gemfibrozil and
Fenofibrate ligands for? |
|
Definition
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Term
Gemfibrozil
Fenofibrate increases ______ catabolism and reduces _____ |
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Definition
| FA VLDL so you increase turnover of fats |
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Term
Gemfibrozil
Fenofibrate used to treat____ |
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Definition
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Term
what mainly do Gemfibrozil
Fenofibrate do? |
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Definition
| lower triglycerides and raise HDL |
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Term
Gemfibrozil
Fenofibrate pharmackinetics? |
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Definition
absorbed from GI and goes enterohepatic circulation.
eliminated through kidneys |
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Term
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Definition
| rare cases of rash, GI symptoms, myopathy, arrhythmias, hypokalemia & high aminotransferase or alkaline phosphatase levels, risk of cholesterol gallstones. |
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Term
Drug interactions of Gemfibrozil
Fenofibrate |
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Definition
| increase anticoagulent effect |
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Term
contraindications Gemfibrozil
Fenofibrate |
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Definition
| dont use in pts with liver or renal dysfunction |
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Term
| whats the major drug in nicotinic acid? |
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Definition
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Term
| what does the nicotinic acid do? |
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Definition
treats combined dyslipidemias(excess lipid in blood)
lower LDL and VLDL levels
inhibit lipolysis in adipose tissue receptor...reduces camp and inhibits hormone sensitive lipase
-reduce FA, VLDL synthesis and LDL levels
-lowers triglycieride and LP |
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Term
| what are some side effects of niacine? |
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Definition
| flushing, hyperuricemia, glucose intolerance, and hepatic dysfunction |
|
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Term
| what are some contraindicatins of niacin? |
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Definition
|
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Term
| what are bile acid binding resins? |
|
Definition
| colestipol and cholestryamine |
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Term
| how do the c bile acid binding resins work? |
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Definition
binds bile acids in the intestine and its pooped out
prevent bile reasportion
b/c no bile acids in poop -> u have liver sensing u need more bile acids then you have increased oxidation of cholesterol to bile acids
Results: incerase in LDL RECEPTORS..and you lower LDL serum levels |
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Term
| so what do colestipol and cholestyramine do? |
|
Definition
| lower ldl increase HDL and TG |
|
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Term
| pharmacokinetics of bile acid binding resins? |
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Definition
|
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Term
| what are the side effects of bile acid binding resins? |
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Definition
consitpation-may cause increase in VLDL so add a naicain
if they dont have LDL receptor..then doesnt work. bc drug increases LDL receptor |
|
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Term
| what are drug interacitons |
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Definition
interfere with normal fat digestion and abosrption
and stop absorption of VIT A D E K |
|
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Term
| WHAT ARE D HMG co-a reducatase inhibitors? |
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Definition
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Term
| what do the d hmg coa reductase inhibitors do? |
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Definition
they are competitive inhibitors of hmg-coa reducatse
they DEC LDL
induction leads to making lots of LDL receptors
lower serum LDL levels
increasing LDL receptors is the most imprortant part of the mech |
|
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Term
| statins-what effect do they have on bones? |
|
Definition
| inhibit osteoclastic activity |
|
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Term
| what are side effects of statins? |
|
Definition
Elevations of serum aminotransferase, doesn't result in hepatotoxicity
In 2% of patients who have liver dz maybe have > 3x elevations in aminotransferase levels and that may indicate HEPATOTOXICITY
myositis(muscle pain)
rhabdomyolysis-> making myoglobinemia -> may lead to acute renal failure. |
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Term
| Drug interacctions of statins |
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Definition
drugs that compete for CYP3A4 OR CYP2C9
Drugs that induce CYP will lower plasma statin levels |
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Term
| Contraindications for statins |
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Definition
| Preggers due to potential teratogenicity |
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Term
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Definition
lowers uptake of gi cholesterol(both dietary and biliary)
makes lots of high affinity ldl -> removal of LDL from blood |
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Term
| waht effect does serum ldl and triglycerides does ezemtibme have? |
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Definition
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Term
| what are an indication with ezetimibe? |
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Definition
| lots of cholesterol(hypercholesterolemia) |
|
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Term
| how do u get toxicity with ezetimibe? |
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Definition
| with HMG COA reducatse inhibitors |
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