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407 exam2.3
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26
Biology
Undergraduate 4
03/11/2014

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Term
infertility-
Definition
cant conceive after 1 yr of unprotected sex.
Term
infertility prevalence
Definition
1/10 couples
increased rate in last 10 years by 20%
Term
causes of infertility
Definition
hormones, body fat too high or too low, PCOS, premature ovarian failure, Age, anatomical problem
Term
Amenorrhea
Definition
no period. primary- no menarche by 16. secondary after 3months
Term
Anovulation
Definition
failed ovum release
Term
oligomenorrhea
Definition
infreq. periods
Term
Adipose tissue contains which enzyme that does what
Definition
aromtase converts androgens to estrogens. Obese ppl have increased estrogen
Term
excess estrogen in obese ppl causes problems with
Definition
GnRH which then affects LH and FSH. it then relates to anovulation bc failed ovum release
Term
FSH
Definition
matures follicle
Term
LH
Definition
releases ovum from follicle
Term
Fertility related to BMI and age
Definition
high BMI and young, fertility decreases
High BMI and >35 no effect
Term
low body fat
Definition
delayed menarche, 2nd amenorrhea, anovulation, early menopause
Term
1960s rose frisch
Definition
critical BF level for menarche. leptin signals bodys energy reserves to hypothalamic-pituitary-ovarian axis that governs fertility. Leptin increase w/ BF stimulating the GnRH pulse and stimulates FSH
Term
PCOS
Definition
bearded women. 6-10%
hormonal imbalance: increased androgen (affects follicular dev. due to low LH, FSH) , insulin resistance.
Term
PCOS levels of LH and FSH and problem
Definition
low. follicles dont develop and become fluid filled cysts
Term
PCOS and insulin resistance
Definition
too much insulin
metabolic disorders- obesity, lipid abnormalities, HTN, Hyperglycemia
increase type 2 diabettes, heart disease, endometrial cancer
Term
PCOS can lessen w/
Definition
lifestyle change: 10% weight loss restores menses
BC decreaces andgrogens
Term
Premature ovarian failure:
Definition
depletion of follicles by 40y= premature menopause
associated w/ autoimmune disorders and cancer tx
Term
hormone levels in premature ovarian failure
Definition
increased FSH, GnRH, decreased estrogen
Term
40yr + increases
Definition
miscarriage
multi births
chromosome abnormality
Term
Trisomy 21
Definition
risk increases w/ age.
unusal ear folds, crease across center hand, 2jts 5th finger, unusal face, sandal toe, small mouth, large tongue
Term
biomarkers for trisomy 21
Definition
decreases estriol, AFP
increases HCG
Term
intrauterine insemination
Definition
sperm placed in uterus (scarred uterus or male impotence)
Term
3rd party assisted ART
Definition
sperm donation, egg donation, surrogates
Term
In vitro fertilization
Definition
stim egg mature, retrival, fertilized, incubate, embryonic transfer
Term
rise in multibirths due to
Definition
ART. 1995 22%, no 32%
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