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Term
| Key intrxn of this [image] |
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Definition
Key intrxn:[EPINEPHRINE]
-H bonding of catechol OH
-B-hydroxylamine w/ Asp residue in TM3 and Asn in TM7 |
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Term
primary metabolites found in urine
-NE METABOLISM |
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Definition
~VMA-Vanillylmandelic Acid
~4Hydroxy-3-methoxy-phenylglycol |
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Term
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Definition
Levalbuterol (levorotatory R isomer)
S has no activity |
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Term
| Albuterol is a _______mixture |
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Definition
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Definition
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Definition
Salmeterol
(long acting B-agonist) |
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Definition
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Term
| active isomer of formoterol |
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Definition
Arformoterol
active R,R isomer |
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Term
BETA AGONISTS
Short acting
Long acting
Ultra Long
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Definition
Short acting-Albuterol
Long acting-Salmeterol, Formoterol
Ultra Long- Vilanterol, Olodaterol, Indacaterol |
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Definition
| Cortisol (hydrocortisone) |
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Mometasone (not prodrug)
least systemic activity...minimizes side effects |
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Definition
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Term
| Inc both anti inflamm & Mineralcorticoid act |
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Definition
9-alpha F or Cl
-slows oxidation of 11B-OH by 11B-HSD |
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Term
| Inc anti inflammatory act |
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Definition
-Delta 1 bond(C1-C2 doubl bond)
-6alpha-F |
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Term
| Dec mineral corticoid act |
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Definition
-6alpha-methyl
-16alpha & 18alpha methyl
-16alpha OH
-16alpha,17alpha0acetonide and Derivs |
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Term
SHort Acting Muscarinics
Long acting Muscarinics |
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Definition
SHort Acting Muscarinics-Atropine. Ipatropium
Long acting Muscarinics- Tiotropium, Aclidinium,Umeclidinium |
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Term
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Definition
Caffeine
Theophylline
Theobromine
Aminophylline(theophylline Deriv) |
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Term
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Definition
| Roflumilast (orally.not inhaled) |
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Term
Mast cell Stabilizer
[image] |
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Definition
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Term
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Definition
Zileuton
Zafrilleukast, Montelukast (Leukotriene Antagonists) |
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Term
| TYROSINE CONVERTED TO L-DOPA BY |
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Definition
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Term
| DOPAMINE CONVERTED TO NE BY |
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Definition
| DOPAMINE BETA HYDROXYLASE |
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Term
| EPINEPHRINE CATECHOL OHs BIND TO |
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Definition
2 SERINE GROUPS ON BETA RECEPTOR
[BETA HYDROXYLAMINE INTERCTS W/ Asp RESIDUE IN TM3 AND Asn IN TM7] |
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Term
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Definition
| FAD (FLAVIN ADENINE DINUCLEOTIDE) IN RXN RXN YIELD AMINE & ALDEHYDE |
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Term
| AMINE SUBSTITUTION DETERMINES |
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Definition
BETA VS ALPHA RECEPTOR SELECTIVITY
[BULKIER FAVOR BETA AND MORE RESISTANT TO MAO ACTIVITY] |
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Term
ALBUTEROL IS RESISTANT TO
SLOWLY METAB BY |
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Definition
ALBUTEROL IS RESISTANT TO comt
SLOWLY METAB BY mao |
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Term
| SALMETEROL RESISTANT TO METAB BY |
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Definition
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Term
| 2 CHIRAL CENTERS AND 4 POSSIBLE STEREOISOMERS |
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Definition
FORMOTEROL (ACTIVE RR ISOMERS)
SS INACTIVE |
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Term
| INDACATEROL AND OLODATEROL ARE USED |
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Definition
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Definition
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Definition
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Definition
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Definition
| GC RECEPTOR AFTER PASSIVE DIFFUSION THROUGH CELL AND BINDING DNA TO INHIBIT CYTOKINE PRODUCTION |
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Term
CORTICOSTEROID METABOLISM=
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Definition
CLEAVE SIDE CHAIN
REDUCE "A" RING |
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Term
| IN CORTICOSTEROIDS THESE INC ANTI INFLAMM & MC ACTIVITY |
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Definition
9alpha F or Cl
[also slows 11b-HSD oxidation of 11b-OH] |
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Term
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Definition
prodrugs
----c21 oh group required for receptor binding |
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Term
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Definition
| increases duration of action and dec MC activity |
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Term
| in methylprednisolone this group dec mineralcorticoid activity |
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Definition
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Term
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Definition
mometasone furoate
beclomethasone dipropionate
fluticasone propionate |
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Term
| Corticosteroid acetonides |
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Definition
flunisolide
budesonide
ciclesonide |
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Term
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Definition
| G-protein coupked receptors |
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