Term
| over production of keratin, decreased keratin desquamation -> marked thickening of keratin layer (hyperkeratinosis) |
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Definition
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Term
| Microscopic appearance: thick stratum corneum, thin epidermis |
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Definition
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Term
| Defect: unknown, possibly increased cohesiveness of cells of stratum corneum |
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Definition
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Term
Inheirted as autosomal disorder;
defect on chromosome 12: ATP2A2 gene |
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Definition
| Darrier Disease (Keratosis Follicularis) |
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Term
| Keratosis Follicularis AKA |
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Definition
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Term
Lesions:
tan colored papules 2-4 mm diameter
warty elevations : forehead, ears, back, scalp, chest |
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Definition
| Darrier Disease (Keratosis Follicularis) |
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Term
Microscopy:
papule shows cleft above basal layer
root of cleft -> cone of compact keratotic material |
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Definition
| Darrier Disease (Keratosis Follicularis) |
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Term
May occur at any age
Associated w/ arthritis, myopathy, enteropathy, AIDS |
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Definition
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Term
| Site: elbows, knees, scalp, lumbosacral, intergluteal cleft, glans penis |
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Definition
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Term
Macro:
well demarcated, pink plaques covered by silvery scales |
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Definition
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Term
| May occur as total body erytema and scaling -> erythroderma |
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Definition
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Term
| Rarely, small pustules form on plaques |
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Definition
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Term
Microscopic:
ACANTHOSIS w/ elongated rete ridges
p
PARAKERATOSIS
ABSENCE OF granular cell layer
MITOSES above basal layer
Dilation of blood vessels in dermis -> clnical erythema |
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Definition
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Term
| Collections of neutrophils within superficial epithelium known as |
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Definition
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Term
| psoriasis lesions at site of trauma |
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Definition
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Term
| Chronic BLISTERING SKIN DISORDER, autoimmune in nature |
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Definition
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Term
| affects all age groups, most common 40-60 yrs |
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Definition
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Term
| Blister formation due to diminished cohesiveness of keratinocytes |
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Definition
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Term
| outer epidermis separated from dermis -> suprabasilar blisters |
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Definition
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Term
Blisters contain:
lymphocytes, macrophages, eosinophils, neutrophils, esp in pervascular areas |
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Definition
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Term
Direct IF reveals intercellular deposits of IgG and complement
(in epidermal keratinocytes) |
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Definition
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Term
| Lesions on scalp, *mucus membranes*, periumbilical area |
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Definition
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Term
| Maybe associated w/ AI disorders : MG, SLE |
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Definition
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Term
| Characterized by formation of blister in Basement membrane zone @ sites of trauma |
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Definition
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Term
| Blisters noted @ birth or soon after |
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Definition
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Term
transmitted as AD trait
Bulla disease |
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Definition
| Epidermolytic EB (EB Simplex) |
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Term
| cytolysis of basal keratinocytes -> blisters heal by scarring |
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Definition
| Epidermolytic EB (EB Simplex) |
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Term
| Transmitted as AR trait (Bulla Disease) |
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Definition
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Term
| blisters within lamina lucida |
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Definition
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Term
| course of disease from benign -> severe and fatal in 2 years |
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Definition
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Term
| transmitted as AD or AR trait |
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Definition
| Dermolytic (or dystrophic) EB |
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Term
| blisters beneath lamina densa |
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Definition
| Dermolytic (or dystrophic) EB |
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Term
| blisters heal leaving atrophic scarring |
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Definition
| Dermolytic (or dystrophic) EB |
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Term
| common autoimmune blistering disorder affecting elderly people |
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Definition
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Term
| Inner aspects of thighs, flexor surfaces of forearms, axilla, groin, lower abdomen |
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Definition
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Term
| Detachment of epithellium from underlying CT, possibly due to immunologically mediated damage to basement membrane |
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Definition
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Term
Micro:
Subepidermal nonacantholytic blister; perivascular infiltrate of lymphocytes and EOSINOPHILS |
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Definition
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Term
Bulla contain:
eosinophils, lymphocytes, neutrophils, and fibrin |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| IF shows *linear BMZ deposits* of IgG and complement |
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Definition
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Term
| Rare, chronic recurrent, pruritic disease; age of onset third nad fourth decades M>F |
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Definition
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Term
| Extensor surfaces - elbows and knees, upper back (shoulders), buttocks: bilateral and symmetrical; ORAL MUCOSA NOT AFFECTED |
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Definition
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Term
| Associated w/ gluten sensitivity |
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Definition
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Term
| Vesicles often grouped as true herpesvirus infection |
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Definition
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Term
| Neutrophils, eosiinophils, and fibrin at tips of dermal papillae (microabscesses) |
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Definition
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Term
| overlying basal cell vacuolization -> microscopic blisters - coalesce -> large subepidermal blisters |
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Definition
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Term
| IF testing shows granular deposits of IgA at tips of dermal papillae |
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Definition
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Term
| Individuals w/ HLA-B8 and HLA-DR3 particularly prone to this disease |
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Definition
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Term
Acute self-limited dermatosis produced by allergic reaction to drugs (sulfonamides, penicillin, barbituates)
infections (herpes, mycoplasma, histoplasmosis, coccidiomycosis, typhoid), malignancy (carincomas, lymphomas), collagen-vascular diseases( SLE, dermatomyositis) |
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Definition
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Term
| Believed to be due to cell mediated immune injury |
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Definition
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Term
| Lesions may be widespread and present as macules, papules, vesicles, and bullae |
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Definition
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Term
| Target lesion (iris lesion) - central dark red zone occasionally w/ blister surrounded by paler area |
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Definition
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Term
| Severe, febrile form of erythema multiforme; more common in children; characterized by swelling, bleeding, and serosanguineous crusting of lips and oral mucosa. Conjunctiva, urethra and anogenital regions may also be affected |
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Definition
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Term
Microscopic:
keratinocyte degeneration and necrosis -> vesiculation |
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Definition
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Term
| Dermis shows varying intensity of lympho-histiocytic infiltration. |
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Definition
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Term
| Central nerosis surrounded by perivenular inflammation |
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Definition
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Term
usually limited to skin
face, malar, scalp ears
Lesions start: slightly elevated papules w/ rough scale of keratin
later: disc shape w/ hyperkeratotic margin and pale center
may form disbursing scars |
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Definition
| Chronic Cutaneous (discoid) Erythematosus |
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Term
irregular proliferation and thinning of epithelium
edema at DE junction |
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Definition
| Chronic Cutaneous (Discoid) Erythematosus |
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Term
vacuolation of basal cells
patchy infiltrate of lymphocytes
thickening of basment membrane zone |
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Definition
| Chronic Cutaneous (Discoid) Erythematosus |
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Term
| Deposition of immune reactants along BMZ-> positive lupus band test |
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Definition
| Chronic Cutaneous (Discoid) Erythematosus |
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Term
| ANA seen in less than 10% |
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Definition
| Chronic Cutaneous (Discoid) Erythematosus |
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Term
| humoral and cell mediated mechanisms -> destruction of *pigment containing basal cells* |
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Definition
| Chronic Cutaneous (Discoid) Erythematosus |
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Term
besides skin, MSK system and kidneys involved
upper chest, upper back, extensor surfaces of arms |
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Definition
| Subacute Cutaneous Erythematosus |
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Term
lesions begin as erythematous papules which enlarge and form annular lesions
no signficant scarring |
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Definition
| Subacute Cutnaeous Erythematosus |
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Term
| ANA levels elevated in 70% |
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Definition
| Subacute Cutaneous Erythematosus |
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Term
maculopapular rash of chest and extremities
delicate erythema of malar area of face (butterly rash) lasts a few hours / days
lesions heal w/o scarring |
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Definition
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Term
| ANA levels elevated in more than 90% of patients |
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Definition
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Term
Common chronic skin / mucus membrane disease self-limiting
resolve in 1 to 2 years, oral persists several years |
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Definition
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Term
| Wickham striae: violaceous papules w/ white dots or lines |
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Definition
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Term
Multiple lesions often symmetric; frequently on extremities and often on wrists and elbows.
Oral lesions: white reticularted areas on mucosa (buccal, lateral part of dorsum) |
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Definition
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Term
Micro:
parakeratosis
saw tooth pattern of deep surface of epithelium
liquefaction degeneration at DE junction |
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Definition
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Term
Anucleate, necrotic basal cells -> colloid or civatte bodies
Dermis 0> dense band like infiltrate of mononuclear cells T lymphocytes may predominant in upper dermis |
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Definition
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Term
| cause unknown, cell mediated injury to basal cells |
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Definition
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Term
| wheal formation from focal mast cell degranulation. mainly young adults |
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Definition
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Term
| Micro: scanty perivascular infiltrates of mononuclear cells; no increase in mast cells |
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Definition
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Term
| massive escape of fluid into tissues from BVs -> large edematous swellings |
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Definition
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Term
Autosomal Dominant Disorder
mutation of C1-esterase inhibitor |
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Definition
| Hereditary angioneurotic edema |
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Term
| Involve GI tract an larynx. Laryngeal edema may be fatal |
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Definition
| Heriditary angioneurotic edema |
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Term
| AKA Allergic cutaneous vasculitis, leucocytoclastic vasculitis, hypersensitivity angiitis |
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Definition
| Cutaneous Necrotizing Vasculitis |
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Term
| circulatory immune complex deposited in vascular walls at site of injury or where venous circulation slowed |
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Definition
| Cutaneous Necrotizing Vascultitis |
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Term
| netrophils attracted to sites of deposition, release lusomal enzymes -> endothelial damage -> fibrin deposition |
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Definition
| Cutaneous Necrotizing Vasculitis |
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Term
| may be associated with HBV or HCV , RA, SLE, UC (ulcerative colitis), lymphoma |
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Definition
| Cutaneous Necrotizing Vasculitis |
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Term
| Micro: neutrophilic infiltration of vessel wall, fibrin deposition, extravasion of blood cells |
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Definition
| Cutaneous Necrotizing Vasculitis |
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Term
| Clincal: multiple purpuric papules 2-4mm usually on lower extremeities or sites of pressure. Small blood vessels in joints, GI, kidney may be involved |
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Definition
| Cutaneous Necrotizing Vasculitis |
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Term
| Pathology: separation of epidermal keratinocytes by edema fluid -> spongiosis |
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Definition
| Allergic contact dermatitis |
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Term
| occurs as response to indigestible antigens accidently implanted into skin (breast implant) |
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Definition
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Term
formation of granulomas
Pathology |
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Definition
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Term
granulomatous disease, cause uknown
lungs, skin, lymph nodes, spleen etc.
epitheloid granulomas NO central necrosis
skin lesions: papules, plaques, nodules in dermis/subcutis |
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Definition
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Term
besides skin. kidneys, heart, lungs, esophagus, SI may be involved
disorder of dermal CT |
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Definition
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Term
lesions in dermis
-large collagen bundles parallel to epidermis, hypocellular
-patchy lymphocyte and plasma cell infiltration |
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Definition
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Term
-sweat glands and hair follicles obliterated
-late stage: subcutaneous fat replaced by collagen |
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Definition
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Term
peak incidence 30-50 years
F:M 4:1 |
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Definition
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Term
non pitting edema of hands or fingers
affected areas hard and tense, mask like face
late stage: skin all over body thick, dense, fibrotic, and fixed to underlying tissue |
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Definition
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Term
| most common form of panniculitis |
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Definition
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Term
| acute onset often associated with infections (streptococcal, TB, coccidiomycosis, histoplasmosis) drugs (sulfonamides, OCs), sarcoidosis, 1BD |
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Definition
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Term
| Lesions: poorly defined, very tender, erythematous nodules, often involving lower legs |
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Definition
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Term
| May be accompanied by fever and malaise, lesions later become flat no residual scars |
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Definition
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Term
| CT septa widing with edema, fibrin deposition, neutrophilic infiltrate; later replaced by lymphohistiocytic infiltration w/ giant cells and eosinophils. No vasculitis |
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Definition
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Term
Uncommon panniculitis, cause unknown
Primary affects adolescents and menopausal women |
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Definition
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Term
| Considered as primary vasculitis of deep vessels supplying subcutaneous fat -> necrosis and inflammation of adipose tissue |
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Definition
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Term
| Lesion: erythematous, slightly tender nodule, usually ulcerates and scars |
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Definition
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Term
| Micro: necrotizing vasculitis affecting small to medium sized arteries and veins in deep dermis and subcutis follweod by granulatous inflammation and necrosis |
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Definition
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Term
| Most common skin disease seen in derm |
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Definition
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Term
| Micro: neutrophilic inflammation surrounding ruptured sebaceous follicle, numerous macrophages |
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Definition
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Term
| Propionibacterium acnes break down sebaceous oils 0> irritating fatty acids -> inflammation |
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Definition
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Term
| Accumulation of sebum and epithelial debris -> distension and rupture of follicle and discharge of contents to surrounding dermis -> intense acute inflammatory reaction |
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Definition
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