Term
aripiprazole-abilify
class:dopamine agonist;Antipsychotic
action:Diminishes schizophrenic behavior
use: tx schizo/bipolar;adjuvant tx major depres.dx
dosage: 10-15mg/day; max 30mg
Side effects: wt gain, HA, insomnia, V/N, akathisia, drowsy
complications: EPS, Neuroleptic malignant syndrome, leuko/neutropenia
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Definition
contraindication: NONE
Interactions: ETOH, carbamazepine, fluoxetine, itraconazole, ketoconazole, paroxetine, quinidine, St. John's wort, kava kava, valerian
Implications: watch wt, EPS, tardive dyskinesia, B/P, pulse, assess therapeutic response |
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Term
benztropine-cogentin
class: anticholinergic; antiparkinson agent
action:reduces incidence of akinesia, rigidity, tremor
indications:tx parkinsons, drug-induced EPS reactions
dosage:0.5-6mg/day in 1 or 2 divided doses
EPS- 1-4mg 1 or 2/day
side effects: drowsy, dry mouth, blurred vision, constipation, decr. diaphoresis or urination, GI upset
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Definition
complications:severe anticholinergic effects (unsteadiness, drowsy, tachycardia, dyspnea, skin flushing, dry mouth/nose/throat); hallucination, tremor, seizure
contraindications:glaucoma, prostatic hyperplasia
interactions:ETOH, CNS depressants, amantadine, anticholinergics, MAOIs, antacids, antidiarrheals
implications:watch for neurologic effects, HA, drowsy, confusion, agitation; assess for sx improvement |
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Term
chloropromazine-thorazine
class:phenothiazine; antipsychotic, antiemetic, antianxiety, antineuralgia adjunct
action:improves psychotic conditions, N/V
use:psychotic dx, manic/depr., N/V
dose:10-25mg q4-6
side effects:drowsy,dizzy,blurred vision,hypotension,constipation,dry mouth,nasal congestion
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Definition
complications:EPS,parkinsonism, dystonias, opisthotonos, oculogyric crisis
interactions:ETOH, CNS deprs. MAOIs, tricyclic antideprs.,antithyroid,EPS meds,antihypertensives, lithium
contraindications:comatose,myelosuppression,CVD, CNS deprs.
implication:B/P, EPS, WBC, fine tongue mvmnt, suicide-risk |
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Term
clozapine-Clozaril
class:dibenzodiazepine/antipsychotic
action:diminishes schizo behavior
use:schizo, recurrent suicial behavior (Bipolar, OCD)
dose:12.5mg 1or2/day; range 200-600mg/day. max 900mg/day
side effects:drowsy, dizzy, salivation, tachycardia, |
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Definition
constipation, hypotension, HA, tremor
complications:seizures, CNS + resp. deprs.
contraindication:coma, use of other drugs suppressing bone marrow fx, severe CNS deprs., granulocytopenia
interactions:ETOH, antihypertensive, CNS deprs., bone marrow deprs., SSRIs, lithium
implications: B/P, pulse, CBC, suicidal risk |
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Term
fluphenazine-Prolixil
class:phenothiazine/antipsychotic
action:decr. psychotic behavior;weak anticholin., sedative, antiemetic; high EPS
use:psychosis, (neurogenic pain)
dose:2-40mg/day; I: 12.5-75mg q2wk
side effect:hypotension, dizzy, drowsy,dry mouth, blurred vision,lethargy,constipation/D,peri.edema
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Definition
complication:EPS, parkinsonisminteractions:ETOH, CNS deprs, antithyroid, antihypertensive, MAOIs, lithium
contraindication:glaucoma, myelosupprs, severe cardiac/hapatic dx, severe hyper/hypotension
implications:B/P, CBC, fine tongue movement, suicidal risk
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Term
haldoperidol-Haldol
class:antipsychotic, antiemetic, antidyskinetic
action:tranquilizing effect, high EP, antiemetic effects; weak anticholinergic, sedative effects
use:tx psychoses, tourettes, emergency sedation of severly agitated pts, (n/v assoc. w chemo)
dose:2-40mg/day
SE:blurred vision, constipation, ortho hypo, dry mouth, swollen/sore breasts, peri. edema
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Definition
complication:EPS, lethargy, tardive dyskinesia
interaction:ETOH, CNS deprs, epinephrine,EPS,lithium, kava kava, St. Johns wort, valerian
contraindication:glaucoma, CNS deprs, myelosuprs, parkinson's, severe caridac/hapatic dx
implication:suicide risk, rigidity, tremor, fine tongue movement |
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Term
loxitane-Loxapine
class:antipsychotic
action:may antagonize dopamine action as a neurotransmitter in basal ganglia and limbic system. antipsychotics may block postsynaptic dopamine receptors, inhibit dopamine release, incr. dopamine turnover
use:tx psychotic illness
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Definition
dose:20-250mg/day
SE:high EPS, low anticholin, mod sedation +hypotens.
complication:
interaction:
contraindication:
implication: |
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Term
molindone-Moban
class:antipsychotic
action:
use:manage schizo
dose:50-225mg/day
SE:CNS, EPS, tardive dyskinesia, parkinsonian
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Definition
complication:neuroleptic malign. syndrm
interaction:
contraindication:ETOH, CNS deprs
implication: |
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Term
olanzepine-Zyprexa
class:dibenzapin derivative/antipsychotic
action:diminishes psychotic sx
use:psychotics, acute mania w bipolar
dose:10-20mg/day
SE:drowsy, agitation, insomnia, HA, nervous, hostility,dizzy,rhinitis, wt gain
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Definition
complication:seizure, neurolptc malign. sydm
interaction:ETOH,CNS deprs, anticholin, hepatotoxic, St. johns wort, kava kava, valerian, dong quai, gotu kola
contraindication:NONE
implication:B/P, tremors, gait, suicide risk, sleep |
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Term
paliperidone-Invega
class:antipsychotic
action:suprs psychosia
use:tx schizo/affective; adjunct for mood +antideprsts
dose:3-12mg/day
SE:tachycardia, HA, drowsy, akathesia, anxiety, dizzy, syspepsia, nausea
complication:neuro mlgn syndrm
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Definition
interaction:ETOH, dopamine agonists, levodopa, CNS deprsnt
contraindication:sensitive to risperidone, meds that prolong QT interval
implication:B/P, wt, HR, renal fx tests, EKG, fine tongue mvmnt, suicide risk, neurol malign syndrm |
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Term
quetiapine-Seroquel
class:dibenzapine derivative/antipsychotic
action:diminishes psychotic dx, produces moderate sedation, low EPS, no anticholinergic effects
use:tx schizo, acute manic episodes w biplr, deprs
dose:100-800mg/day
SE:HA, drowsy, dizzy
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Definition
complication:heart block, hypotens, hypokalemia, tachycardia
interaction:ETOH, CNS deprs, antihyperten, hepatic enzyme inducers
contraindication:NONE
implication:B/P, pulse, eye exam, bowel, suicide risk |
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Term
risperidone-Risperidal
class:benzisoxazole derivative/antipsychotic
action:suppresses psychotic behavior
use:manages psychotic
dose:2-6mg/day
SE:agitation, anxiety, insomnia, HA, constipation, N/V, dyspepsia abd pain |
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Definition
complication:tardive dyskinesia, neuro malgn syndr, hyperglycemia
interaction:ETOH, CNS deprs, antihypertn, clozapine
contraindication:NONE
implication:B/P, HR, wt, hepatic fx test, EKG, fine tongue mvmnt, suicide-risk, neuro malgn syndr, glycemia
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Term
thiothixine-Navane
class:antipsychotic
action:suppresses psychotic behavior
use:symptom managmnt schizo (psychosis)
dose:5-60mg/day
SE:drowsy, dry mouth, constipation, blurred vision, nasal congestion, N/D, peri edema, urinary retention
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Definition
complication:akathisia, akinesia, dystonias, tardive dyskinesia
interaction:ETOH, CNS deprs, EPS, levodopa, quinidine
contraindication:bld dyscrasias, circulatory collapse, CNS deprs, coma, hx seizures
implication:
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Term
trifluoperazine-Stelazine
class:phenothiazine/antipsychotic, antianxiety
action:supres behav respone in psychosis; reduces locomotor activity, aggressiveness
use:tx schizo, non-psychotic anxiety (psychotic dx)
dose:5-80mg/day
SE:hypotension, dizzy,dry mouth, D, lethargy
complicaton:EPS, dystonia, tardive dyskinesia
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Definition
interaction:ETOH, CNS deprs, antacids, antithyroid, EPS, hypotenisve agents, levodopa, lithium, MAOIs, antideprsnts
contraindication:glaucoma, circulatory collapse, myelosuprs, severe cardiac/hepatic dx, severe hyper/hypotension
implication:B/P,EPS,WBC,fine tongue mvmnt |
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Term
trihexiphenidyl-Artane
class:anticholinergic/antiparkinson agent
action:decr salivation, relaxes smooth muscle
use:adjunctive tx for all forms of parkinsons dx; controls sx of drug-induced EPS
dose:5-15mg/day in 3-4 divided doses
SE:>60yo develop mental confusion, agitation; drowsy, dry outh
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Definition
complication:CNS deprs, hypersensitivity
interaction:ETOH, CNS deprs, MAOIs, anticholing, amantadine, antacids, antidiarrheals
contraindication:glaucoma, GI obstruction, paralytic ileus, intestinal atony, megacolon
implication:alert for neurologic effects (HA, lethargy, mental confusion, agitaion |
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Term
ziprasidone-Geodone
class:piperazine derivative/antipsychotic
action:diminishes sx of schizo, deprs
use:tx schizo, acute bipolar mania, acute agitation
dose:40-160 mg/day
SE:HA, drowsy, dizzy, rash, ortho hypo, wt gain, restless, constipation, dyspepsia
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Definition
complication:prolongation of QT interval
interaction:ETOH, CNS deprs, carbamazepine, ketoconazole, all foods enhance bioavailability
contraindication:risk of prolonged QT interval
implication:monitor wt; assess therap rsponse
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