Term
| Cell depleting Induction Tx |
|
Definition
Polyclonal antibodies (Thymoglobulin)
Monoclonal Antibodies (Alemtuzumab) |
|
|
Term
| Non-Cell depleting Induction Tx |
|
Definition
Basiliximab
Corticosteroids |
|
|
Term
Classification of antibodies:
-MOMAB |
|
Definition
|
|
Term
Classification of antibodies
-XIMAB |
|
Definition
-Chimera
-75% human, 25% murine |
|
|
Term
Classification of antibodies
-ZUMAB |
|
Definition
-Humanized
-95%, 5% murine |
|
|
Term
Classification of antibodies
-UMAB |
|
Definition
|
|
Term
THYMOGLOBULIN:
Anti-thymocyte Glubulin
{INDUCTION Tx} |
|
Definition
-Slow long infusion
-1-6 mnth 1/2 life
-4-6hr infusion |
|
|
Term
Anti-thymocyte Glubulin SFX
{INDUCTION Tx} |
|
Definition
-Leukopenia
-Thrombocytopenia
-Anemia, fever, chills, hypotnsn |
|
|
Term
Alemtuzumab
{INDUCTION Tx} |
|
Definition
-anti CD52
-1/2 life 9-18 months
-2 hr infusion |
|
|
Term
Alemtuzumab premedicate w/ ???
{INDUCTION Tx} |
|
Definition
APAP, Diphenhydr
(Steroids used too if Rx not for induction) |
|
|
Term
Basiliximab
{INDUCTION Tx} |
|
Definition
|
|
Term
Basiliximab SFX
{INDUCTION Tx} |
|
Definition
| rare hypersensitivity rxns requiring supportive care |
|
|
Term
Corticosteroids
{INDUCTION Tx} |
|
Definition
|
|
Term
| Immunosuppressive agent Targets |
|
Definition
Signal 1: TCR. On cell surface.recognize foreign antigens
Signal 2: T cell activation
Signal 3: T cell proliferation |
|
|
Term
Maintenance Drug classes
{MAINTENANCE Tx} |
|
Definition
Calcineurin inhibs
Co-stimulate inhibs
Corticosteroids
mTOR Inhibs
ANtiproliferatives |
|
|
Term
| Cyclosproine USP is_______ as Cyclosporine Modified |
|
Definition
|
|
Term
First line/ usual med
{MAINTENANCE Tx} |
|
Definition
Tacrolimus
(Calcineurin inhib) |
|
|
Term
Calcineurin inhibs be careful with....
{MAINTENANCE Tx} |
|
Definition
|
|
Term
CYP3A4 INHIBITORS
[increase calcineurin Rx levels] |
|
Definition
-macrolides
-azoles
-CCBs
-PIs
-Amiodarone |
|
|
Term
CYP3A4 INDUCERS
[dec calcineurin Rx levels] |
|
Definition
-St johns wort
-Anticonvuls
-Efavirenz
-Rifamycins |
|
|
Term
Calcineurin inhibs SFX
{MAINTENANCE Tx} |
|
Definition
Nephrotoxic,HTN
Neurotox
HLD,Hperglyc
ALopecia
Osteoporosis |
|
|
Term
| CYCLOSPORINE Monitor {MAINTENANCE Tx} |
|
Definition
Peak: 400-1200 mg/ml C2
Trough: 100-400ng/ml
-IV dose 33-50% PO dose |
|
|
Term
Tacrolimus Monitor
{MAINTENANCE Tx} |
|
Definition
|
|
Term
Belatacept has/....
{MAINTENANCE Tx} |
|
Definition
-Belatacept has REMS program
-outpatient infusion
[Co-stimulate inhibitor] |
|
|
Term
Belatacept administer with
{MAINTENANCE Tx} |
|
Definition
-Basiliximab
-AND Mycophenalate
-AND Corticosteroid |
|
|
Term
| Belatacept Contra in who? |
|
Definition
| Pt W/out exposure to EBV(epstein bar virus) |
|
|
Term
Belatacept SFX
{MAINTENANCE Tx} |
|
Definition
-Anemia, leukopenia, GI, edema
(has No infusion rxns!) |
|
|
Term
Azathioprine MOA
{MAINTENANCE Tx} |
|
Definition
-Antiproliferative agent
-PRODRUG
-Disrupts DNA synthesis |
|
|
Term
|
Definition
-leukopenia(dose limitng)
-ANemia
-Thrombocytoppenia
-NV
-Alopecia,hepatoTOX, pancreatitis |
|
|
Term
| AZATHIOPRINE DRUG INTRXNs |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
- has two peaks do to hepatic recirculation
-MPAG inactive form
-MPA is ACTIVE |
|
|
Term
| Mycophenolate Drug intrxn |
|
Definition
-increased levels when taken w/ Acyclovir/Gancyclovir
-Dec w/ cholestyramine/antacids
-Cyclosporine blocks hepatic recirculation |
|
|
Term
|
Definition
GI tox (reduce dose or chang to Azathi)
ALopecia
Rash
Hepatotox
Pancreatitis
Pancytopenia |
|
|
Term
|
Definition
-Everolimus
-Sirolimus
MOA:inhbit IL-2 and IL15 prolif of T&B cells |
|
|
Term
| WHy loading dose of SIROLIMUS??? |
|
Definition
|
|
Term
| Separate Sirolimus and _______ |
|
Definition
Cylosporine.
-They inc eachother's conc
-Separate by 4 hrs |
|
|
Term
|
Definition
-Pancytopenia
-mouth sores
-HLD
-Pneumonitis
-Proteinuria |
|
|
Term
|
Definition
-Proteinuria
-Lipid levels |
|
|
Term
| Calcinuerin inhibitors interact with..... |
|
Definition
|
|
Term
| Most adult transplant recipients should be treated with..... |
|
Definition
STATINS
[except 18-29 yrs old] |
|
|
Term
| Dont use for pain in transplant Pt |
|
Definition
|
|
Term
| Sleep meds for Transplant? |
|
Definition
-Melatonin
-OTC Diphenhydr
-Zolpidem
-Trazodone |
|
|
