Term
| 7 formed elements of blood |
|
Definition
1. RBCs
2. Platelets
3. Neutrophils
4. Eosinophils
5. Basophils
6. Monocyte
7. Lymphocyte |
|
|
Term
|
Definition
Single lobed nucleus
Contains some azurophilic granules, not nearly as many as granulocytes |
|
|
Term
|
Definition
6-8 microns, about the same size as RBCs.
20-25% of leukocytes
Large nucleus with small cytoplasm. Can be mistaken for basophils, need to look at size (basophils larger).
Can return to bloodstream after diapedesis to form memory cells. |
|
|
Term
|
Definition
1. B lymphocytes (CD20): for humeral system.
2. T lymphocytes (CD4 and CD8)
3. Natural Killer cells |
|
|
Term
|
Definition
12-20 microns, much larger than RBCs
3-8% of leukocytes
Nucleus is oval, kidney, or horseshoe shaped.
Distinguish kidney shaped monocyte nucleus and band neutrophil by size (monocyte larger).
Have tons of organelles in TEM since monocytes differentiate into many other cells. |
|
|
Term
|
Definition
Macrophages (histiocytes)
Langerhans cells in skin
Osteoclasts in bone
Microglia in the CNS
Perivacular macrophages in CNS
Antigen presenting cells (MHC II) in spleen and lymph node |
|
|
Term
|
Definition
1. Megakaryocyte extends processes into capillaries.
2. Membrane invaginations shed along demarcation lines to become platelets. |
|
|
Term
|
Definition
| Polyploid, has multiple copies of DNA. |
|
|
Term
| Platelet appearance in LM |
|
Definition
Appear as clumps in peripheral blood smear.
Have lighter staining peripheral zone (hyalomere).
Have darker staining granular zone (granulomere). |
|
|
Term
| Platelet granulomere region |
|
Definition
Contains glycogen
Unpolymerized myosin
Monomeric G actin
and 3 granules:
Lambda granules
Delta granules
Alpha granules |
|
|
Term
|
Definition
| In granulomere region of platelet, contains lysosomes. |
|
|
Term
|
Definition
Contains ATP, ADP, pyrophosphate, serotonin, and calcium.
Found in granulomere region of platelet. |
|
|
Term
|
Definition
| Contain fibrinogen, PDGF, and other platelet recruiting factors. Found in platelet granulosome region. |
|
|
Term
|
Definition
| Has coat rich in GAGs and glycoproteins essential for aggregation. |
|
|
Term
|
Definition
| On border of platelet, contains actin and myosin, gives platelet its shape. |
|
|
Term
|
Definition
| Invaginations in the platelet membrane that creates a larger surface area, allows the platelet to rapidly secrete granules to stop bleeding. |
|
|
Term
|
Definition
| Derived from the endoplasmic reticulum of megakaryocyte, stores Ca2+ ions. |
|
|
Term
| Fibrin function in clot formation |
|
Definition
| Forms meshwork that traps RBC to form thrombus. |
|
|
