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305 exam4 lec.6
Innate/Adaptive Bridging Responses
30
Biology
Undergraduate 3
12/04/2013

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Term
what type of response is natural killer cells
Definition
Innate/Adaptive Bridging Responses
Term
what do nk cells do?
Definition
seek and destroy anything that looks like it doesn’t belong
Term
what type of immune cell are NK cells?
Definition
lymphocytes
Term
How does a NK cell look for abnormal cells? what type of response is this?
Definition
If a cell has a Lack of MHC 1 (“self”) it indicates to NK that there is infection/cancer and NK will destroy it.
(innate)
Term
How does a NK cell destroy a cell?
Definition
Anitbody-dependent cellular cytotoxicity ADCC
Term
What is ADCC?
Definition
NK cell use Fc receptors to recognize cells coated with antibody.
Nuke abnormal cells by inducing apoptosis
Term
NK cells are most closely related to :
Definition
B and T cells
Term
Opsinosation means
Definition
theres some chemoreactant covering object causing macrophage or dendritic cells to want to eat it.
Term
Antibodies are good-
Definition
coatings for opsinosation
Term
NK cells interacting with Salmonella Typhirium example:
Definition
Antibodies will surround salmonella using there antibody binding sites and the “y’ points in towards the cellular membrane and a series of Fc portions sticking outwards. NK cells recognize that portion using th Fc receptors.
Term
What type of response is complement?
Definition
mostly innate w/an adaptive component
Term
What is complement?
Definition
20 blood proteins made by liver; found everywhere- free flowing in blood.
Term
2 Functions of Complement
Definition
1. Protease to cause protylysis
2. chemoattractant (self cleaving) functions
Term
3 results from complement:
Definition
1. lysis (inserts pores into membranes)
2. causes inflammation (attracts WBC)
3. Opsonize: increases rate of consumption by coating microbe
Term
What are the pore causing microbes?
Definition
NK, complement, defensens?
Term
Complement has # of initiation/ activation methods? they are:
Definition
3
lectin pathway
atlernative path
classical path
Term
Lectin pathway is what type of response? What happens?
Definition
Innate
Microbial sugar-based cmpds like NAG, LPS, teichoic acids cause liver to secrete lectin
Term
Alternative pathway is what type of response? What happens?
Definition
Innate
LPS G- and teichoic acids G+
Term
Classical pathway is what type of response? What happens?
Definition
innate/adaptive interaction-> antibody dependent
First one discovered bc it is antibody dependent it can be considered aquired
Term
LPS is
Definition
very good at starting complement system thru alternative pathway. Toll-like receptors can bind LPS= another innate response
Term
In complement, what is always floating around? What happens if antibody or lectin is around or something initiates a response?
Definition
C3 always floating around. C3 can cleave itself and is started if antibody, lectin around. Something initiates it.
Term
C3 breaks into :
Definition
into two independent subunits= C3a and C3b.
Term
C3a
Definition
is the signal of infection.
Term
C3b
Definition
C3b is opsonin and attaches itself to things to increase phagocytosis to occur and goes beyound that to be a protein interaction
Term
when C3b interacts with other proteins to form
Definition
C5 =convertase which will clip C5 into 2 pieces C5a and C5b
Term
C5b
Definition
is a protein that together with last bullet combines to form MAC and starts to form pores.
Term
Complement is good for
Definition
eliminating pathogens
Term
What is MAC? what is it made up of?
Definition
C5b + C6, C7, C8, C9 = membrane attack complex
Term
C3a +C5a cause -- which see--
Definition
inflammation attract phagocytes-> which see the opsonized microbe coated with C3b
Term
Complement is focused on -- and is seperate from --. Works best on: -- bc --
Definition
Complement is separate from inflammation. It really focuses on the series of proteins htat cut each other up. Works better for G- bc G+ have sucha thick cell wall.
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