Term
| what type of response is natural killer cells |
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Definition
| Innate/Adaptive Bridging Responses |
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Term
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Definition
| seek and destroy anything that looks like it doesn’t belong |
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Term
| what type of immune cell are NK cells? |
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Definition
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Term
| How does a NK cell look for abnormal cells? what type of response is this? |
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Definition
If a cell has a Lack of MHC 1 (“self”) it indicates to NK that there is infection/cancer and NK will destroy it.
(innate) |
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Term
| How does a NK cell destroy a cell? |
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Definition
| Anitbody-dependent cellular cytotoxicity ADCC |
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Term
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Definition
NK cell use Fc receptors to recognize cells coated with antibody.
Nuke abnormal cells by inducing apoptosis |
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Term
| NK cells are most closely related to : |
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Definition
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Term
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Definition
| theres some chemoreactant covering object causing macrophage or dendritic cells to want to eat it. |
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Term
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Definition
| coatings for opsinosation |
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Term
| NK cells interacting with Salmonella Typhirium example: |
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Definition
| Antibodies will surround salmonella using there antibody binding sites and the “y’ points in towards the cellular membrane and a series of Fc portions sticking outwards. NK cells recognize that portion using th Fc receptors. |
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Term
| What type of response is complement? |
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Definition
| mostly innate w/an adaptive component |
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Term
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Definition
| 20 blood proteins made by liver; found everywhere- free flowing in blood. |
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Term
| 2 Functions of Complement |
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Definition
1. Protease to cause protylysis
2. chemoattractant (self cleaving) functions |
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Term
| 3 results from complement: |
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Definition
1. lysis (inserts pores into membranes)
2. causes inflammation (attracts WBC)
3. Opsonize: increases rate of consumption by coating microbe |
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Term
| What are the pore causing microbes? |
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Definition
| NK, complement, defensens? |
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Term
| Complement has # of initiation/ activation methods? they are: |
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Definition
3
lectin pathway
atlernative path
classical path |
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Term
| Lectin pathway is what type of response? What happens? |
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Definition
Innate
Microbial sugar-based cmpds like NAG, LPS, teichoic acids cause liver to secrete lectin |
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Term
| Alternative pathway is what type of response? What happens? |
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Definition
Innate
LPS G- and teichoic acids G+ |
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Term
| Classical pathway is what type of response? What happens? |
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Definition
innate/adaptive interaction-> antibody dependent
First one discovered bc it is antibody dependent it can be considered aquired |
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Term
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Definition
| very good at starting complement system thru alternative pathway. Toll-like receptors can bind LPS= another innate response |
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Term
| In complement, what is always floating around? What happens if antibody or lectin is around or something initiates a response? |
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Definition
| C3 always floating around. C3 can cleave itself and is started if antibody, lectin around. Something initiates it. |
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Term
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Definition
| into two independent subunits= C3a and C3b. |
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Term
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Definition
| is the signal of infection. |
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Term
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Definition
| C3b is opsonin and attaches itself to things to increase phagocytosis to occur and goes beyound that to be a protein interaction |
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Term
| when C3b interacts with other proteins to form |
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Definition
| C5 =convertase which will clip C5 into 2 pieces C5a and C5b |
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Term
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Definition
| is a protein that together with last bullet combines to form MAC and starts to form pores. |
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Term
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Definition
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Term
| What is MAC? what is it made up of? |
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Definition
| C5b + C6, C7, C8, C9 = membrane attack complex |
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Term
| C3a +C5a cause -- which see-- |
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Definition
| inflammation attract phagocytes-> which see the opsonized microbe coated with C3b |
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Term
| Complement is focused on -- and is seperate from --. Works best on: -- bc -- |
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Definition
| Complement is separate from inflammation. It really focuses on the series of proteins htat cut each other up. Works better for G- bc G+ have sucha thick cell wall. |
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