Term
| influenza enveloped or non? |
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Definition
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Definition
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Term
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Definition
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Definition
Horizontal
Aerosolization
Direct contact (less common) |
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Term
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Definition
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Term
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Definition
Acute
Cough, fever, sore throat, runny nose, ache, fatigue |
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Term
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Definition
Upper respiratory tract
Lower respiratory tract |
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Term
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Definition
Hemagglutinin (“H”) binds to host cell receptor- protein
Put into viral envelope for viral escape, binds to host cell receptor to make host cell come in
Endocytosis
Contents released into cytoplasm |
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Term
| influenza Replication/assembly |
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Definition
BYOP (bring your own polymerase
ss(-)RNA → mRNA
Random packaging |
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Term
| influenza Random packaging |
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Definition
| packaging in cytoplasm (needs all 8 segments to be functional |
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Term
| influenza makes ss + RNA for |
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Definition
| to make ss(-)RNA to make more genetic material |
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Term
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Definition
Budding
Neuraminidase (N cuts and releases virions. No vessicle, no real exocytosis. |
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Term
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Definition
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Term
| influenza tx using tamiflu and relenza: |
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Definition
Neuraminidase inhibitors
Doesn’t let virus escape the host cell. The host keeps making more virus particles but they can’t leave with “N” inhibited. Past 72 hours there is too many viruses within you.
A lot of resistance against these “N” changes fast |
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Term
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Definition
| random minor mutations, common, minor capsid change, avoid immune system |
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Term
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Definition
Annual flu vaccine
Rhinoviruses
HIV |
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Term
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Definition
| MAJOR CHANGES: completely new proteins made= completely new viruses, uncommon |
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Term
| antigenic shift potential |
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Definition
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Term
| how does antigenic shift occur? |
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Definition
New segmented genome is created by
Two strains infect a single host (chicken, pig)usually in foreign countries
Genetic recombination/reassortment occurs between strains=major changes |
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Term
| example of antigenic shift |
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Definition
| Influenza- has segmented genome* the key for this shift |
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Term
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Definition
Disease source + factors influencing spread
Develop control/prevention strategies
frequency of disease |
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Term
father of epidemioloogy=
in Golden age?
studied= |
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Definition
John Snow GOLDEN AGE
1854 London cholera outbreak |
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Term
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Definition
| always present at low frequency (west nile) |
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Term
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Definition
| Epidemic: high freq quickly in small area (flu) |
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Term
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Definition
| epidemic in a wide area (typically multiple countries/continents) |
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Term
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Definition
| location dependent (seattle vs 3rd world country has different respone) and Pt zero/ person to blame |
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Term
| Managing Infectious Diseases includes: |
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Definition
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Term
| Just watching the disease |
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Definition
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Term
| facts- who, what, where (no WHY) |
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Definition
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Term
| relationships/assiociations with the disease but NOT WHY |
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Definition
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Term
| looking back at data in the past |
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Definition
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Term
| future: follow group over time |
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Definition
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Term
| determine why/reason something is happening, hypothesis, test |
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Definition
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Term
| (hypothesis: cholera is “caused by” water at the broad st. pump) |
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Definition
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Term
| (cases most prevalent near broad st pump) |
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Definition
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Term
WSU/Equine Herpes Virus (EHV-1) enveloped?
genome=
host range-
endemic, epidemic, pandemic?
disease course- |
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Definition
enveloped
dsDNA baltimore 1
narrow host
endemic (US)
latent |
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Term
| WSU/Equine Herpes Virus (EHV-1) transmission |
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Definition
Airborne/aerosolization
Fomites (equipment, clothing)
Vectors (humans)
Asymoptomatic carriers |
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Term
| WSU/Equine Herpes Virus (EHV-1) tropism |
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Definition
| Respiratory, reproductive, central nervous systems (EHM = Equine Herpes Myeloencephalopathy) |
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Term
| WSU/Equine Herpes Virus (EHV-1) entry and release |
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Definition
Uncoats at cell membrane
Capsid travels to nucleus
DNA enters
release= exocytosis |
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Term
| WSU/Equine Herpes Virus (EHV-1) tx |
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Definition
Vaccinations available
Difficult to control
Supoortive care |
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Term
| pt zero WSU/Equine Herpes Virus (EHV-1) |
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Definition
| 4/29-5/8/11: National Cutting Horse Association Western National Championship Ogden, UT |
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