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305 exam2 #6
n/a
35
Biology
Undergraduate 3
10/13/2013

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Term
Malaria is caused by
Definition
by 4 Plasmodia species
Term
malaria tranmission
Definition
Horizontal (biological vector= mosquito)
Vertical
Term
malaria infects annualy
Definition
300-500 million infected annually
1-3 million die (esp. children)
Term
malaria attachment
Definition
Apical complex- group of organelles that allows microbes to latch on to outside of cell and drill its way in.
Term
malaria disease course
Definition
Acute/chronic (if untreated/ resistant)/ latent
Term
malaria symptoms
Definition
Episodes of violent chills, high fever, sweat (microbe release+ RBC debris)
Seems flu-like but short 10hrs
Possible anemia
Term
malaria and mosquito relationship
Definition
commensle
Term
stage one malaria
Definition
1. Sporozoites- mosquito takes a blood meal injecting sporozoites (form of microbe)
Term
stage two malaria
Definition
2. Sporozoites infect liver cells and multiply like crazy. Forms a shizont (host cell infected) merozoites are released out to blood
Term
stage 3 malaria
Definition
3. Merozoites start infected RBC –latch on, multiply and create another shizont (different than liver cell) this is when chills and fever and flu0like symptoms start.
Term
stage 4 malaria
Definition
4 Some differentiate and form gamets- meiosis. This allows for sex cells to form. Another mosquito bites person and takes up the produced gamet.
Term
stage 5 malaria
Definition
5. Gamets enter mosquito, fuse together= oocyst and form sporozoites. Evolutionary advantage is if different gamets are in the mosquito= more diverse genes
Term
stage 6 malaria
Definition
6. Liver cell that doesn’t form shizont would go into Latent stage-> wait until it wakes up and then disease starts over again.
Term
mosquito's role in malaria is
Definition
intrinsic
Term
control of malaria
Definition
Mosquito nets
Vaccine
Term
tx of malaria
Definition
Drugs, but many strains resistant
Term
related to malaria
Definition
apicomplexans
Term
apicomplexans
Definition
Toxoplasma gondii protist
Term
Toxoplasma gondii protist
symptoms
Definition
Usually flu-like, but vertical transmission can be fatal
Live in biological/animal vectors that live outside
Term
Tropism=
Definition
host tissue perference
Term
viral Host recognition and attachment
Definition
Hijacking cell surface receptors
Term
viral genome entry
Definition
Internalization of whole virus
Membrane fusion (if enveloped)
Endocytosis (vessicle comes into cell)
Term
basic of viral life cycle
Definition
host recognition and attachemhent
genome entry
virion particle assembly
exit, transmission , and spread
Term
west nile envoloped or not?
Definition
enveloped
Term
type of genome of west nile
Definition
ss(+)RNA baltimore=4
Term
host range of west nile
Definition
broad
Term
classify west nile virus on how bad it is
Definition
Originally “foreign” but now endemic (low, constant occurrence)
Term
west nile tramsission
Definition
Horizontal
Biological vector= mosquitoes (direct thru mosquito)
Vertical
Mosquitoes to baby mosquito
Term
disease course of west nile and symptoms
Definition
Acute
Asymptomatic or “flu like”
Neurological problems (encephalitis/swelling)
Term
birds and horses are a -- for WNV
Definition
biological resevoir
Term
WNV tropism
Definition
Blood tissues (viremia)
Lymph nodes
Brain/nervous tissue
Term
entry of WNV
Definition
endocytosis
Term
Replication/assembly
for WNV
Definition
ss(+)RNA (4) -> (-)RNA-> mRNA (for proteins/capsid) and template for (+)ssRNA for more genetic materia
Term
release WNV
Definition
Exocytosis (no lysis) vesical fusion+ release, more regulated
Term
control/tx WNV
Definition
Vaccinations (horses)
Supportive care (fluids, anti- inflamation)
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