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303 exam3 lec. 18
G3P shuttle
8
Biochemistry
Undergraduate 3
12/07/2013

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Term
What problem does the G3P shuttle solve?
Definition
Reoxidizing cystolic NADH back to cystolic NAD+ aerobically bc you cant use lactate DH since pyruvate enters TCA and is unavaiable. The inner membrane is impermeable to NAD which controls the NAD ratio. *The key is that we need to re-oxidize NADH aerobically
Term
What solution does the G3P give?
Definition
Cystolic NADH is reoxidized to NAD+ aerobical via an indirect transfer of e- via G3P shuttle. 2 e- are transported across the membrane (since NADH itself can't be)
Term
go thru the steps of the G3P shuttle
Definition
Term
What is the p/o ratio of cystolic NADH
Definition
1.5 ATP bc it enters at complex 3 (complex 3+4=6H+ =1.5 ATP)
Term
Atp produced by glycolysis and G3P shuttle=
Definition
2 ATP glycolysis +1.5 ATP shuttle
Term
How many atp per glucose
Definition
30
**know how to get this number with each step!!!
Term
Where does atp come from for 100m dash vs marathon
Definition
glycolysis- dash
TCA-marathon (glucose will be oxidized to CO2 aerobically)
Term
Why use anaerobic glycolysis for a dash>
Definition
bc rate of rxn in glycolysis is much faster to go to lactate then oxidation/respiration. About 2x faster=6x more atp. downside is lactate = fatigue
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