Term
| 1st step pyruvate to acetyal coA happens (where?) |
|
Definition
| insdide mitochondria where it then enters the TCA |
|
|
Term
| stage two of aerobic metabolism |
|
Definition
oxidation of acetl groups in citric acid cycle includes 4 steps where e- are removed
=acetyl co A oxidation via TCA |
|
|
Term
| stage 3 aerobic metabolism |
|
Definition
| e- are carried by NADH and FADH2 and funelled into a chain of mitochondrial e- carriers the respiratory chain ultimately reducing 02 to to H20 |
|
|
Term
| stage 1 of aerobic metabolism |
|
Definition
| acetyl co A production from oxidation of FA glucose and some AA |
|
|
Term
Glycolysis occurs in
oxygen? |
|
Definition
| the cytosol. No O2 needed= anaerobic, but can occur in the prescence of o2 |
|
|
Term
pyruvate Dehydrogenase
does-
5 coenzymes= |
|
Definition
2pyruvate -> 2acteyl co A + 2Co2 in mitochondria
NAD+, FAD, coenzyme A, thiamine, phosphate, linolinc acid |
|
|
Term
|
Definition
| decarboxylation: acetyl CoA ester of acetic acid (sulfur forms thioester) ketone group is oxided by NAD to carboxylic acid (thioester)= high energy bond= acetyl group would rather be somewhere else. |
|
|
Term
|
Definition
| ADP W/phosphoryl group n 3' hydroxyl + Panthenic acid (b vit.) + beta mercaptoethylamine |
|
|
Term
|
Definition
| C-C bon= not easy= why high energy bond in acetyl CoA is improtant the acetyl group would rather be attachted to ketone group of oxaloacetate and coA comes off. |
|
|
Term
|
Definition
| hydroxyl grop does a intramolecular migration from 3C to 2C of iso citrate. |
|
|
Term
|
Definition
| oxidative decarboxylation C6->C5 alpha ketoglutartae and 2nd CO2 comes off |
|
|
Term
|
Definition
| OH on 2C on isocitrate is oxided to ketone (by oxidizing agent NAD) causing carboxyl group to be unstabe and come off as CO2 |
|
|
Term
| alpha ketoglutarate DH complex catalyzes: |
|
Definition
C5->C4 +Co2
THIS RXN is similar to pyruvate DH**study similarities |
|
|
Term
| Pattern between pyruvate DH and alpha keto glutarate DH rxn |
|
Definition
| both rxns are oxidization phosphorylation of alpha keto acid. can be applied to an AA rxn. What vitamins and substraes/products are involved? |
|
|
Term
|
Definition
| 2C enter and condense with 4C of oxaloacetate= 6C rearrange +2x oxidative phosphorylation 2C flow in and 2C flow out as CO2. Important to form lots of reducing power for ETC drive ATP to form. |
|
|
Term
|
Definition
| 3 NADH 1 FADH2 1 GTP 2CO2 per pyruvate, so per glucose its times two |
|
|
