Term
| Collection apheresis can be used to collect which blood components? |
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Definition
| plasmapheresis, plateletpheresis, RBC apheresis (erythrocytapheresis) |
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Term
| What are situations in which apheresis can be therapeutic? |
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Definition
| leukapheresis (for hyperleukocytosis), red cell exchange (sickle cell syndromes), therapeutic plasma exchange, peripheral blood stem cell collection (transplant) |
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Term
| A single donor aperesis platelet unit equals ___ "pooled" units. |
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Definition
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Term
| What are the different categories for diseases when it comes to apheresis treatment? |
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Definition
category I= standard acceptable therapy
II= efficacy usually as adjunctive tx
III= inconclusive
IV= lack of evidence in controlled trials |
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Term
| What autoimmune diseases can be treated by TPE? |
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Definition
| thrombotic thrombocytopenic purpura, myesthenia gravis, guillian barre |
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Term
| What is the usual plasma replacement fluid used during therapuetic plasma exchange? |
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Definition
| 5% albumin unless the pt has TTP or has low coag factors in which case you use FFP |
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Term
| Removing and replacing 1.0 plasma volumes results in a ___% overall plasma exchange. |
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Definition
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Term
| Does exchanging plasma become more or less efficient the longer the procedure continues? |
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Definition
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Term
| What are risks associated with apheresis? |
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Definition
| citrate effect (circumoral paresthesia, feeling vibration or buzzing, tingling), calcium depletion, vasovagal response, IV access complications, line infections |
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Term
| What should you do if a patient is experiencing the citrate effect? |
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Definition
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Term
| What do you give to patients in order for them to donate stem cells through a peripheral blood sample? |
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Definition
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Term
| What happens to stem cells after they are removed from the donor via apheresis? |
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Definition
| counted by flow cytometry, selected (usually by immunoadsorption techniques), frozen and stored until needed |
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Term
| What are the symptoms of TTP? |
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Definition
| Fever, Anemia (MAHA), Thrombocytopenia, Renal abnormalities (mildly increased BUN/Cr), Neurologic changes |
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Term
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Definition
| ultra-large vWF because ADAMTS-13, an enzyme normally found in plasma is deficient d/t autoantibodies |
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Term
| What labs should you get if you suspect TTP? |
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Definition
| platelet count (low), HCT (anemia can be mild), LDH (400-600= hemolysis, >1000= tissue damage), blood smear (schistocytes), BUN/Cr |
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Term
| What is the treatment for TTP? |
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Definition
| therapeuticplasma exchange; remove pt's plasma with auto-ab against ADAMTS-13 and replace with donor plasma that contains ADAMTS-13 |
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Term
| Why can't you replace plasma with 5% albumin in apheresis for TTP? |
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Definition
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Term
| What labs do you need to check daily after performing plasmapheresis on a TTP patient? |
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Definition
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