Term
| where is gastrin produced? |
|
Definition
G cells of ANTRUM
Duodenum |
|
|
Term
| What stims gastrin secretion? |
|
Definition
protein
vagal input (ACh)
Ca
EtOH
distension
pH>3 |
|
|
Term
|
Definition
| pH < 3 , SStatin ,secretin, CCK ,VIP, GIP, glucagon, calcitonin |
|
|
Term
| What does gastrin target? |
|
Definition
parietal cells (via enterochromafin cells)
chief cells |
|
|
Term
|
Definition
Secretion: HCl, IF, pepsinogen
inc gastric motility
Trophic effects on gastric mucosa |
|
|
Term
|
Definition
| H/K ATPase of parietal cell |
|
|
Term
| where is somatostatin produced? |
|
Definition
|
|
Term
| what stims SStatin release? |
|
Definition
|
|
Term
|
Definition
inhibits gastrin, Hcl
inhibits insuling, glucagon, secretin, CCK, GIP, VIP, motilin release
Dec panc and biliary output
Slows gastric emptyig |
|
|
Term
|
Definition
glucose dependent insulinotropic pepdtide
-K cells duodenu |
|
|
Term
|
Definition
| ONLY by glucose in the stomach |
|
|
Term
|
Definition
| panc beta cells to release insulin |
|
|
Term
|
Definition
|
|
Term
|
Definition
| protein and fat in duodenum |
|
|
Term
|
Definition
GB contraction
Oddi relaxation
Inc panc ENZYME secretion
inc instestinl motility
bile synthesis
Satiety via hypothal receptors |
|
|
Term
| Where is secretin prodcued? |
|
Definition
|
|
Term
| what stims vs inhibits secretin release |
|
Definition
stim = Acidity (pH<4), fat, bile
inhib = pH >4, gastrin |
|
|
Term
|
Definition
-inhibit gastrin (unless gastrinoma), inhib HCL release
-inc panc DUCTAL secretion
-inc bile flow
-inc bicarb secretion from duodenal Brunner Glands |
|
|
Term
| Bicarb vs chloride composition of pancreatic duct output vs flo w |
|
Definition
HIGH output = inc bicarb, dec chloride
Low = low bicarb, high chlordine
**Carbonic anhydrase excahnges bicarb for cl** |
|
|
Term
| most important stim of pancretic ductal cells vs acinar (enzyme) cells? |
|
Definition
Secretin --> ductal
CCK -->acinar cells |
|
|
Term
|
Definition
|
|
Term
|
Definition
Inc intestinal secretion of water/electrolytes
inc motility
Dec gastrin release |
|
|
Term
|
Definition
| alpha cells, pancreas (also some in stomach, intestine) |
|
|
Term
| what stims glucagon release? |
|
Definition
dec glucose, inc aa,
ACh,
GRP,
catacholamines (Beta-adrenergic stim) |
|
|
Term
| What inhibits glucagon release? |
|
Definition
inc glucose, inc insulin,
SStatin,
ketones,
FFA in blood |
|
|
Term
|
Definition
glycogenolysis and glucoeogen (make more glucose)
lipolysis and keotgenesis
proteolysis
----
decreases acid secretion, pancreatic secretion,
dec intestinal motility, gastric motility, MMC,
Increases LES tone |
|
|
Term
| What stimulates insulin release? |
|
Definition
glucose
glucagon
CCK
proteins |
|
|
Term
| what inhibs insulin release |
|
Definition
|
|
Term
|
Definition
glucose uptake
protein, glycogen, triacylglyceride synthesis |
|
|
Term
|
Definition
fasting
exercise
hypoglycemia |
|
|
Term
|
Definition
|
|
Term
|
Definition
| decreased pancreatic endocrine and exocrine function |
|
|
Term
| Where is peptide YY released from? |
|
Definition
|
|
Term
|
Definition
inhibit gastric emptying, acid secretion, panc function, GB contraction
-inc water and electrolyte absorption from colon
-appetite suppressant |
|
|
Term
|
Definition
Gastrin releasing peptide = bombesin
-released from post gang fibers of Vagus |
|
|
Term
|
Definition
| inc gastric acid secretion, inc instestinal motor activity, inc panc ENZYME secretion |
|
|
Term
What releases motilin?
where are motilin receptors located in highest concentration? |
|
Definition
from M cells in duodenum (some in jejunum)
-highest receptor conc: antrum, duod, colon |
|
|
Term
what stims motilin release?
what inhibs it? |
|
Definition
stim: duod acid, vagus->released during fasting/interdigestive period
-inhib: SStatin, secretin, PP, duod fat |
|
|
Term
|
Definition
inc antrum and duod motility (initiates phase 3 of peristalsis/MMC
-same receptor as erythromycin |
|
|
Term
| What hormones mediate anorexia? |
|
Definition
| CCK, peptide YY @ hypothalamus |
|
|
Term
Bowel recover after surgery
-time frame? |
|
Definition
Small bowel @ 24 hrs
Stomach @ 48 hrs
Large bowel @ 3-5 days |
|
|
