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26 Cardiac
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Aerospace Engineering
Undergraduate 1
11/19/2017

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Term
Ductus arteriosus =
Definition
connects DESC AORTA and LEFT PULM ART
(shunt blood from lungs)
Term
Ductus venosum =
Definition
connects PORTAL V and IVC
(shunt blood from liver)
Term
# of umbilical art vs veins?
Definition
2 umbilical arteries (to placenta)
1 umbo vein (from placenta)
Term
first sign of L->R shunt?
Definition
hepatomegaly
Term
Causes of L--> Shunts?
Definition
VSD (MC)
ASD
PDA
Term
basic manifestation of L to R vs R to L shunts?
Definition
L-->R = CHF

R-->L = cyanosis
Term
method to reduce R-->L shunt often performed by children?
Definition
squat = inc SVR = inc flow to lungs
Term
R-->L shunts
Sequelae
Definition
polycythemia
stroke
brain abscess
endocarditis
Term
R-->L shunts
causes?
Definition
4Ts
-Tetralogy (MC cyanotic lesion)
-Transposition
-Truncus arteriosus
-Tricuspid atresia
Term
Treatment of R-->L shunts causing cyanosis?
Definition
1. PGE-1 to keep ductus art open OR..
2. balloon atrial septostomy
Term
PGE-1: role in cyanotic heart disease?
Definition
used to keep open Ductus Art
Term
PPHys behind Eisenmenger's syndrome?
Definition
Sign of inc pulm vascular resistance -->pulm HTN
(Left-->Right, turns Right-->left)
Term
MC congenital heart defect?
Definition
VSD
Term
% of VSD that close spont?
Definition
80% by age 1
Term
When do pts with VSD first present with sxs?
Definition
if large VSD, present by 4-6 weeks.
Term
Medical tx of VSD?
Definition
lasix
dig
ace-i
Term
Timing of VSD repair?
Definition
Large = at one year
Medium = at 5 years
Small = leave alone (80% close spont)
Term
MC indication for VSD repair
Definition
FTT
Term
what is a contraindication to VSD repair?
Definition
PVR > 8 Woods units
*try to reverse with vasodilators..then repair*
Term
% ASD that close?
Definition
90% at 1 year
Term
ASD vs VSD % that close ?
Definition
90% ASD
80% VSD
..at 1 year age
Term
MC type of ASD?
Definition
Ostium secundum
-centrally located, patent foramen ovale
Term
ASD a/w downs?
Definition
Ostium primum
-AV septal defects, or endocardial cushion defects
Term
Timing of ASD repair?
Definition
1-2 years
(earlier if Sx not controlled)
Term
Medication to close PDA?
Definition
indomethacin
(rarely works after neonatal period)
Term
Surg tx of persistent PDA?
Definition
Surgical ligation via left thoracotomy
Term
MC cyanotic congenital heart defect?
Definition
Tetralogy
Term
Components of tetralogy?
Definition
VSD
Pulm Stenosis
Overriding aorta
RVH
Term
Sxs TofF?
Definition
Tet spells
-cyanosis->child squats to inc SVR and inc pulm flow (decreases flow thru VSD)
Term
Morphologic abn found in tetralogy?
Definition
Anterior displacement of the infundibular septum
Term
Medical Tx Tetralogy?
Definition
BBlk
Term
Surgical tx of tetralogy?
Definition
-RV outflow tr obstruction divison
-Patch enlargement outflow tr
-VSD repair
Term
timing of tetralogy operation?
Definition
3-6 months (earlier if worsening cyanosis)
Term
left vs right dom coronary artery meaning?
Definition
-Right dominant (MC) = posterior desc off RCA
-Left dom (10%) = PDA off Circumflex
Term
Br of Left main CA?
Definition
left ant descending and cirucmflex
Term
location of most atherosclerotic lesions?
Definition
proximal coronary
Term
patency rate of PCA/stent?
Definition
90% @ 1 year
-saphenous v graft - 80% @ 5 y
-IMA = 90% @ 20 y
Term
best conduit for CABG?
Definition
Int mam
Term
cadioplegia soln/timing of effect?
Definition
K+ and cold soln
-arrest heart in diastole
Term
Indications for CABG
Definition
Stenosis >70%
-left main disease
-left main equiv (LAD and prox circumflex)
-3 vessel disease
-2 vessel disease w/proximal LAD stenosis AND..
LVEF < 50% OR extensive iscehmia
-1 or 2 vessel disease w/large area on viable myocardium and high risk criteria
-Unstable angina, life threatening arrhythmia, ongoing ischemia despite non surgical therapy
Term
High mortality risk factors for CABG?
Definition
#1 = pre-op cardiogenic shock
Emergency surgery
age
reop
low EF
Term
MC time-frame for mechanical cx after MI?
Definition
3-7 days
Term
DDx mechanical Cx after MI?
Definition
1. Vent septal rupture: holosystolic at right sternal border
2. Pap m rupture: acute mitral regurg, holosystolic at axilla
3. Free wall rupture : fatal
Term
PA cath findings with L==>R shunt?
Definition
Step-up in O2 content betwen RA and pulm artery
-ddx VSRupture vs pap muscle rupture after MI
Term
Tx options for mechanical cx after MI?
Definition
IABP (inc survival @ VSR and MR 2/2 papillary rupture)
Term
Timing of LV aneurysm after MI?
Definition
late after large, transmural, anterior MI
-Sx CHF, arrhythmia, angina
-Surg vs refractory Sx
Term
MC heart valve lesion?
Definition
AS
Term
PPhys of AS?
Definition
Early: normal CO and pressures maintained
Late: LVH --> dec compliance-->pulm congestion-->LV fail
Term
Aortic stenosis
-Cardinal Sx and implication for survival?
Definition
Angina: 5 year mean survival
Syncope: 3 year
Dyspnea at rest: 2 year
Term
Valve area considered severe AS?
Definition
< 1 cm2
Term
Indications for AS repair?
Definition
1. Sxs
2. Asympt + valve area < 0.6 cm2
Term
MCC aortic insuff?
Definition
annuo-aortic ectasia
Term
PPHys of aortic insuff?
Definition
-LV dilation->inc wall tension (laplace)-->LV failure
Term
Aortic insuff
-indications for OR?
Definition
Symptomatic (HF, angina not 2/2 CAD)
-OR..Asympt w/either
1. EF<50
2. LV dilation (>70mm end diastolic measurement)
3.Root dilation > 4.5
Term
MCC Mitral stenosis
Definition
Rheumatic fever
Term
Complications/risks of mitral stenosis?
Definition
-pulm congestion, a-fib
-mural thrombi formation (50% go to cerebral circ)
Term
Tx options for mitral stenosis?
Definition
Balloon commissurotomy
-Surgery for severe MS/sxs
Term
MCC mitral regurg?
Definition
Myxomatous degeneration (ie MVP)
Term
Mitral regug pphys?
Definition
LV dilation = inc wall tension
-Dec compliance of LA=>pulm congestion
--> +/-right sided HF +/-afib
Term
Mitral regurg
-OR indications
Definition
1. Sxs (>/= NYHA class 2)
2. Asympt with either
-EF< 60
-LV dilation (end systolic > 45 mm)
-Pulm HTN (PA systolic > 50)
-Afib
Term
Pros/cons of tissue valves?
Definition
Pro: no AC needed
Con: rapid calcification in children/young pts (CONTRAINDICATED IN THESE PTS)
Term
contraindications for tissue valve?
Definition
1. children, younger pts. (rapid calcification
2. Chronic renal dialysis (relative CI)
Term
MC endocarditis Sx?
Definition
Fever
-chills, CHF, stroke
Term
Dx criteria for endocarditis?
Definition
Major
+BCx, +ECHO
Minor
-new murmur
-vascular sxs (emboss, janeway)
-Worsening CHF
-Fever (mc 1-2 hrs after peak bacterem)
-Known RF
-Immune sign: Osler node, Roth spots
Term
Osler node =
Roth spots =
Definition
Osler = tender nodes @ pads of digits
Roth spots = retinal hemorrhages
Term
Endocarditis
-MC org
Definition
Overall: Step Bovis
-acute endo: staph (Also mc iatrogenic)
-chronic endo: strep bovis
MC w/IVDA: pseudomonas (50% @ TV)
Term
Endocarditis
-MC locations
Definition
-MC on left side (unless IVDA)
-MC overall: aortic valve
Term
Initial abx vs Endocarditis?
Definition
vanc and gent
-add rifampin if prosthetic
Term
Endocarditis
-prognostic indicator for surgery pts?
Definition
Pre-op CHF
Term
Endocarditis
-survival after surgery?
Definition
Native valve-->85%
Prosthetic valve --> 75%
*worse due to re-op, inc abscesses, erosion, aneurysm, inc fungal, insidious
Term
Endocarditis
-peri-procedural prophy?
Definition
-Prosthetic valves, hx valve surg
-Rheumatic heart dz
-Congen heart dz
-Hx endocarditis
*first gen ceph 1 day prior*
Term
Acute HF treatment
-initial hemodynamic goals
Definition
MAP> 60
CI 2.2
SVR < 800
Wedge 15-20
Term
Acute HF treatment
-initial tx
Definition
LMNOP
-lasix (wedge 15-20)
-Morphine (venodilate, reudces after load)
-nitrate (venodilate
-O2
-Position (sitting)
Term
Chronic HF treatment
-meds that reduce mortality?
Definition
BBlk (carvedilol)
ACE-H
Spironolactone
Term
types of heart block?
Definition
-1st deg = prolonged PR int (>0.2 msec)
-2nd deg
--type 1 = progressively inc PR int
--type 2 = p wave randomly not f/b QRS
-3rd deg: no assoc btwn P and QRS
Term
Most worrisome heart block types?
Definition
2nd deg type 2 (can degen to complete block)
3rd deg (complete block)
**BOTH REQUIRE PERMANENT PACEMAKER**
Term
MC location for aortic intimal tear?
Definition
Ascending aorta
Term
MCC death w/ ascending aortic dissection?
Definition
2ndary to cardiac failure, MC from aortic insufficiency, tamponade, or rupture
Term
RF for type A dissection?
Definition
HTN,connective tissue dz, fam hx,
bicuspid aortic valve, coarctation, aortitis (takayasu),
3rd trimester preg,
cardiac cath,
cocaine, aneurysm,
atheroslcerotic dz
Term
unique BP finding with aortic dissection?
Definition
R>L arm BP
*use right radial for a line*
Term
Dissection classifications
Definition
1.Stanford A vs B
2. Debakey class:
-type 1 = asc and desc
-type 2 = asc only
-type 3 = desc only
Term
lifetime aneurysm risk after aortic dissection?
Definition
30%
Term
MCC ascending aortic aneurysm?
Definition
Cystic medial necrosis (ex marfans)
Term
thoracic aortic aneurysm
-indications for repair
Definition
sxs
rapid size inc (>0.5 cm/y)
> 5.5 cm @ ascending/arch
***6.5 @ thoracoabd***
Term
MCC thoracic aortic aneurysm based on location?
Definition
asc and arch = cystic medial necrosis
desc = atherosclerosis
Term
Thoracoabd aneurysm repair
-% risk of paraplegia
-how to help prevent it?
Definition
10% w/open surgery
1% w/stent graft
**re-implant intercostals below T8 to help prevent it**
Term
Indications for aortic aneurysm repair based on size/location?
-difference for Marfans pts?
Definition
1. Asc/arch = 5.5
2. desc thoracic/thoracoabd = 6.5
3. abd = 5.5
**marfans get repair at 0.5-1 cm lower than than normal**
Term
Indications for stand-alone MAZE?
Definition
1. refractory Afib/can't tolerate meds
2. a fib for 6 months w/enlarged atrium
3. High risk embolic event (hypercoag state) or C.I to AC
4. s/p stroke despite AC
Term
Key step of MAZE?
Definition
pulm vein isolation
**MAZE can be done OFF BYPASS**
Term
Success rate of MAZE?
Definition
70%
Term
LIMA to LAD patency rate?
Saphenous v graft patency rate?
Definition
90% @ 20 years
80% @ 5 years
Term
Internal mammary artery
-br of..
-branches into..
Definition
-br of Subclavian artery
-br into musculophrenic and sup epigastric a
*also has br to intercostals*
Term
physiology of vasovagal episode?
Definition
-Inc parasymp tone = dec HR
-dec symp tone = dec BP
==>syncope
*carotid stents can distend carotid body-->body thinks BP is high-->inc parasymp/dec symp tone**
Term
Tx vasovagal ?
Definition
leg raise
atropine
Term
Classic pres of post-op cardiac tamponade?
Definition
1. Sudden cessation of mediastinal drainage
2. inc filling pressures (PA, CVP), hypoTN
3. +/- sudden dec UOP
*usually clinical, but get ECHO, CXR if needed*
Term
post op tamponade tx?
Definition
OR if still has pulse
Open chest @ bedside if pulseless
Term
First sign of tamponade on ECHO?
Definition
right atrial diastolic compression
Term
PPhys of tamponade?
Definition
Dec ventricular filling due to pericardial fluid
Term
MC primary cardiac tumor
-overall vs benign vs malig
-MC pediatric primary heart tumor
Definition
Myoxma = MC overall, MC benign
MC malig = angiosarcoma
MC peds = rhabdomyoma
Term
MC met to heart?
Definition
lung CA
Term
IHSS =
-pphys based on vol status?
-tx
Definition
idiopathic hypertrophic subaortic stenosis
-vol up: overload, CHF
-vol down: LV outflow tract collapse, CHF
**usually have associated Mitral regurg**
Term
IHSS
tx
Definition
idiopathic hypertrophic subaortic stenosis
-give sufficient volume
-BBLK vs HR (allows LV filling and stretching of outflow tract)
**avoid inotropes**
Term
coronary vein O2 sat?
Definition
30%
-lowest in body
-high O2 extraction by myocardium
Term
Pt coming of pump, now with dark aortic root vent blood but red perfusion cannula blood.
-tx?
Definition
ventilate lungs
Term
indication for re-op after cardiac surgery based on mediastinal output?
Definition
1. 500 cc over 1st hour
2. >250 cc/4hr
Term
RF for mediastinitis?
Definition
-obesity
-use of bilateral internal mammary art
-DM
-inc blood transfusion
Term
Postpericardiotomy syndrome
sxs
EKG findings
MC cause
tx
Definition
-pericard frinction rub, fever, chest pain, sob, left pleural effusion
-diffuse ST ele (pericarditis)
-MC after CABG
-Tx NSAIDs, steroids
Term
Pt with severe carotid stenosis in need of CABG
-general recommendation?
Definition
1. Asympt >80% or sxs > 70%?
-CEA first. CABG 4 wk later
2. Unstable angina or severe left main dz?
-combined CEA/CABG (CEA first)
*combined procedure stroke risk is higher (6% vs 3% if staged)
Term
Coarctation
-MC location
-mc assoc condition
-common exam finding
-tx?
Definition
-just distal to left SCA
-a/w Turners syndrome
-rib notching from IMA/intercostal collats
-All need repair to prevent CHF
->rsxn and re-anastamosis
Term
Vascular rings
-MC manifestation
-pres
-tx
Definition
double aortic arch
-p/w recurrent pulm infxns, dysphagia
-divide smaller arch via left thora
Term
Transposition of great vessels
-type of shunt/where it shunts through?
-medical Tx options
Definition
-R to L, MC via ASD
-medical: goal = allow mixing
- balloon atrial septostomy (atrial mixing).
-PGE1 to keep PDA open
Term
Transposition
-timing of operation
Definition
No VSD-->1-2 weeks
VSD--> 1-2 months
Term
Truncus arteriosus
-shunt type
-sxs
Definition
R->L
CHF
*has VSD that allows mixing*
Term
Truncus arteriosus
-shunt type
Definition
R->L
Term
Hypoplastic left heart
-procedure to repair?
Definition
Norwood procedure
Term
Tricuspid atreisa
-procedure to repair?
Definition
Fontan procedure
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