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2253 Exam 4-Neonate Brain review
Phuong
120
Other
Not Applicable
04/11/2011

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Term
3 Stage of brain development are
Definition
Cytogenesis-Histogenesis-Organogenesis
Term
In which stage congenital malformations can result when alterations occur
Definition
Organogenesis
Term
The portion of nervous system containing brain and spinal core that develops from the neural plate what is this system?
Definition
Central nervous system
Term
What is the central nervous system develops?
Definition
Neural plate
Term
The neral plate is
Definition
the thick layer of ectodermal tissue giving rise to neral tube and brain, spinal core tissues of CNS
Term
When does the neural plate develops?
Definition
18-20 days after conception
Term
The longitudinal  tube giving rise to brain, spinal core, neural tissue of CNS formed by fusion of the neural folds and paired longitudinal folds uniting to form of what ?
Definition
 Neural tube
Term
What is the neural crest?
Definition
Cells along outer surface of neural tube
Term
Neural tube differentiates into _____
Definition
CNS (brain and spinal core)
Term
Neural crest differentiates into____
Definition
Peripheral nervous system
Term
when the neural tube formation and closure?
Definition

3-4 wk of gestion

 

Term
How is the neural tube formation/closure ?
Definition
The neural plate folds on itself, closes dorsally
Term
Which part of neural tube close first? When it close?
Definition
The cranial end-24days after conception
Term
Which part of neural tube close second? When it close?
Definition
Caudal end -2days later
Term
The cranial end of tube becomes ____
Definition
Ventricular system of brain
Term
The Caudal end of tube becomes __
Definition
Central canal of spinal cord
Term
When is the greatest growth occurs at cranial end?
Definition
End of 4th week gestation
Term
What is the cranial end growth differentiates into?
Definition
3 primary brain vesicles
Term
What are the 3 primary brain vesicles?
Definition
Prosencephalon (forebrain), mesencephalon (midbrain), and rhombencephalon (hindbrain)
Term
4 region of cerebral cortex are_
Definition
Frontal lobe-Parietal lobe-Occipital lobe_Temporal lobe
Term
What is diverticula mean?
Definition
"to turn aside" or folds
Term

Diverticulation occurs at ___in prosencephalon (forebrain) and forms___

 

Definition

5-6 wks gestion

telencephalon and diencephalon

Term
what is the telencephalon?
Definition
Endbrain-gives rise to cerebral hemisphere, lateral ventricles and basal ganglia
Term
What is the diencephalon?
Definition
In between brain- forms thalamus and hypothalamus
Term
what is the rhombencephalon?
Definition
Hindbrain divides into mestencephalon and myelencephalon
Term
what are the Metencephalon and Myelencephalon?
Definition
The lower part or hindbrain from which medulla oblongata develops
Term
Indication for neonate brain exam are
Definition
Congenital anomaliles-Intracranial hemorrhage-Intracranial masses-Venous malformations-Hydrocephalus-Intracranial infections-Infarction and/ or edema
Term
Which is direction of scan in coronal plane?
Definition
Sweep anterior to posterior  and maintain symmetry with transducer place transversely on the fontanelle
Term
Which is direction of scan in sagital plane?
Definition
Scan and take midline image first then scan to right and left to take image on right and left side with transducer place longitudinally across anterior fontanelle
Term
A congenital anomaly associated with spina bifida is called
Definition
Chiari Malformation
Term
Chiari malformation is when___
Definition
Cerebellum and brain stem pulled toward the spinal cord and secondary hydrocephalus develops
Term
Chiari Malformation is characterized by__
Definition

Displacement of 4th ventricle and upper medullar -->cervical canal

Displacement of the inferior part of the cerebellum --> the foramen magnum

Defect in the calvarium and spinal column

Term
Chiari malformation is associated with __
Definition
Myelomeningocele, hydrocephalus, dilation of the third ventricle, and absence of CSP (cavum septum pellucidum)
Term
What is myelomeningocele ?
Definition
Neural tissue and meninges protrude
Term
The most common type of chiari malformation is
Definition
Chiari II
Term
The sign of chiari II is
Definition
Banana sign of cerebellum
Term
Ultrasound finding of Chiari II include:
Definition

Small posterior fossa, and small cerebellum

Displacement of cerebellum -->foramen magnum

Enlarge massa intermedia and ventricles

Partial absence of CSP

Myelomeningocele

Hydrocephalus

Term
Incomplete cleavage of primitive forebrain into 2 cerebral hemispheres and characterized by grossly abnormal brain with common large central ventricle this is____
Definition
Holoprosencephaly
Term
What are 3 type of holoprosencephaly ?
Definition
Alobar-Semilobar-Lobar
Term
The most severe form of Holoprosencephaly is
Definition
Alobar holoprosencephaly
Term
There are multiple facial anomalies, most severe, thalami are fused; no falx, corpus callosum or interhemispheric fissure present; and the third ventricle is absent these are characteristic of___
Definition
Alobar holoprosencephaly
Term
Dilated 4th ventricle in direct communication with cisterna magnum, huge 4th ventricle cyst at cerebellum usually lies, small or absenct cerebellar vermis; Hydrocephalus and elevated tentorium all these are___
Definition
Dandy-Walker Malformation
Term
ACC is
Definition
Agenesis of corpus callosum
Term
Depending on timing this can be partial or complete, this highly associate with central nervous system (CNS) anomalies What is this?
Definition
Agenesis of corpus callosum
Term

What is ultrasound finding of ACC?

 

Definition

Narrow frontal horns (slitlike)

Absent CSP

Widely separated, parallel lateral ventricles

Term
Enlargement of ventricular system; imbalance between production and drainage of CSF this is ___
Definition
Hydrocephalus
Term
If the earlier hydrocephalus occurs the greater ___
Definition
enlargement of the head present
Term
The dilation of ventricles/ hydrocephalus results in__
Definition
Widely separated sutures and huge, bulging fontanelles
Term
Hydrocephalus is
Definition
Dilation of ventricles
Term
US finding of hydrocephalus are
Definition
Blunting of the lateral angles of the lateral ventricles, dilated ventricle atrium >10mm or 1cm
Term
What are types of hydrocephalus?
Definition
Obstructive and communicating
Term
Interference of the circulation of CSF in the ventricular system causes enlargement of the ventricular cavities proximal to the obstruction is what type of hydrocephalus?
Definition
Obstructive hydrocephalus
Term

CSF pathways are open but there is decrease absorption of CSF

The entire ventricular system uniformly distended

What is hydrocephalus type?

Definition
Communicating
Term
When the Germinal Matrix hemorrhage is most at risk?
Definition

GA: < 30 weeks of gestation 

Weight <1500g or both occur

Term
What is germinal matrix?
Definition

The network of blood vessels and primitive neural tissue

This is very sensitive to pressure and metabolic changes which can rupture vessels

Term
When the hemorrhage of germinal Matrix most occur in?
Definition
The first 7 days of life
Term
When is the optimally first US screening check for hemorrhage of Germinal Matrix and Hydrocephalus done at?
Definition
10-14 days
Term
When is the second screening done to check for periventricular leukomalacia and ventricular enlargement?
Definition
4 weeks of age
Term
What is PVL?
Definition
Periventricular leukomalacia
Term
How many grading level of germinal matrix hemorrhage?
Definition
4
Term
Subependymal hemorrhage (SEH) is
Definition
Grade I
Term
Intraventricular extension without hydrocephalus is
Definition
Grade II
Term
Intraventricular hemorrhage with hydrocephalus is
Definition
Grade III
Term
Intraparenchymal hemorrhage is
Definition
Grade IV
Term
Ultrasound finding grade I of (GMH) hemorrhage is
Definition

Homogeneous; moderately to highly echogenic mass

Usually in the caudothalamic groove

Echogenicity of clot changes over time (less echogenic with anechoic center)

Term
Ultrasound finding grade II of (GMH) hemorrhage is
Definition

Hyperechoic clot fills a portion of ventricle or all of ventricle

Choroid plexus may appear asymmetrically thick and difficult to separate choroid plexus from clot

Appearance changes over time

Term
Ultrasound finding grade III of (GMH) hemorrhage is
Definition

Clot then choroid plexus more defined

May be adherent to wall or move to dependent position

Hydrocephalus

Term
Ultrasound finding grade IV of (GMH) hemorrhage is
Definition

Usually in cerebral cortex

Venous infarction secondary to hemorrhage

Acute echogenic homogenous mass extending into brain parenchyma

Over-time echogenic rim with anechoic center

Term
PVL is
Definition

Infarction and necrosis of periventricular white matter

this most frequent ischemic lesion in immature brain

Associate with crebral palsy

Term
PVL asssociated with
Definition
cerebral palsy
Term
PVL is most frequent ischemic lesion in__
Definition
Immature brain
Term
Within 2 weeks of insult, PVL ultrasound finding are:
Definition
Increased echogenicity of periventricular white matter greater than choroid plexus
Term
 Ultrasound finding at 2-4 weeks of PVL___
Definition
Cystic changes may develop single or multiple cysts lateral and superior to top of ventricles and usually bilateral and symmetrical
Term
The main concern with premature infants is
Definition
Brain damage
Term
How many percentage chance of hemorrhage in brain if infants born <34 weeks?
Definition
40-70
Term
Neonatal brain ultrasound is for
Definition
Neonates with difficult delivery or born prematurely
Term
Fissures are
Definition
Sulci
Term
Gyri is
Definition
Elevated folds of tissue
Term
Occipital horn is
Definition
The segment extends posteriorly from the trigone
Term
Frontal horn is
Definition
The segment is divided posteriorly by foramen on Monro near the body of the vent and roof is corpus callosum
Term
Temporal horn is
Definition
The segment extends anteriorly from trigone through the temporal lobe
Term
Trigone (atrium) is
Definition
The anterior, occipital and temporal horns join here, and here is where the ventricle measurements are taken
Term
The fourth ventricle is
Definition
small, thin arrowhead shape, midline cavity that contains CSF and is connected to the 3rd ventricles by the aqueduct of sylvius
Term
The third ventricle is
Definition
Small, teardrop-shaped, midline cavity that lies between thalami, contains CSF and connected to lateral ventricles via foramen of Monro
Term
Cavum vergae is
Definition
 Found on posterior tip of cavum septum pellucidi
Term
Glomus is
Definition
Tail of choroid plexus; major site for bleeds
Term
Aqueduct of Sylvius is
Definition
Midline channel connecting 3rd and 4th ventricles; rarely seen sonographically
Term
Foramen of Monro is
Definition
Midline channel connecting the 3rd ventricle with each lateral ventricle
Term
The Middle cerebral artery (MCA) and circle of Willis is
Definition
Often evaluated with Doppler to determine cerebral blood flow patterns
Term
Massa intermedia is
Definition
Pea-shaped structure suspended within 3rd ventricle and best seen with ventricular dilation
Term
The tentorium cerebelli is
Definition
The structure separates the cerebellum from the cerebrum
Term
Pia mater is
Definition
The innermost membrane that is highly vascularized
Term
Arachnoid is
Definition
Thin, delicate layer between 2 other membranes, surrounded by spaces for CSF
Term
Dura mater is
Definition
Double layered outer membrane, toughest barrier
Term
Meninges are
Definition
3 membranes that surround and protect the brain
Term
The fontanelles are
Definition
Spaces between the bones of the skull; not completely closed in neonate
Term
The quadrigeminal fissure is
Definition
located posterior and inferior from cavum vergae
Term
The interhemispheric fissure is
Definition
Contains the falx cerebri, separates the 2 hemispheres
Term
Sylvian fissure is
Definition
Bilateral located between temporal and frontal lobes; resembles an echogenic "Y" turned on its side, location of MCA
Term
Thalamus are
Definition
2 ovoid egg-shaped structures located on either side of the 3rd ventricle superior to brain stem; relay station for upward moving senory impulses
Term
Hypothalamus is
Definition
under thalamus; regulates body temperature, fluid balance and metabolism; center for thirst ..
Term
Midbrain is
Definition
The narrow portion of brain stem that connects forebrain to hindbrain; contains 2 halves called cerebral peduncles
Term
Cerebellum is
Definition
Structure lies in posterior fossa under tentorium; its 2 hemispheres are connected by the vermis; has cauliflower appearance
Term
Falx cerebri is
Definition
Part of dura mater and found in the interhemispheric fissure; this fibrous structure separating the 2 cerebral hemispheres
Term
Lateral ventricles are
Definition
2 located on either side of the brain; this is largest CSF cavities within the cerebral hemispheres and divided into 4 segments
Term
Body ventricle is
Definition
 The segment extends from foramen of Monro to the trigone; the corpus callosum forms the roof and CSP (cavum septum pellucidum) forms the medial wall
Term
Cerebral spinal fluid are
Definition
Surrounded and protected the brain and spinal cord, 40% formed by choroid plexus of lateral, third and fourth ventricle
Term
Choroid plexus is
Definition
Echogenic cells important in CSF production found in atrium of lateral ventricles; and regulated intraventricular pressure by secretion or absorption of CSF
Term
Cavum septum pellucidum (CSP) is
Definition
Thin, triangular-shaped (coronally), comma-shaped (sagitally) and lies between frontal horns and bodies of the lateral ventricles in midline; forms the floor of corpus callosum and filled with CSF and usually closes within 3-6 months of life
Term
Cisterna magna is
Definition
Small,fluid-filled space immediately posteroinferior to cerebellum; found between medulla oblongata, cerebellar hemispheres and occipital bone
Term
Corpus callosum is
Definition
Group of nerve fibers (mass of white matter) connecting right and left hemispheres; superior to 3rd ventricle; forms roof of lateral ventricle and sits on top of cavum septum pellucidum
Term
Frontal lobe
Definition

Primary motor area, located anterior to cental fissure

Controls the movements of the conscious skeletal muscles such as face, mouth, and hands.

Term
The occipital lobe
Definition
The posterior part interprets visual impulses
Term
Temporal lobe
Definition
Cortical areas, responsible for interpreting impulses from the special sense organs such as the auditory area and olfactory area
Term
Paietal lobe
Definition
Contains the body's sensory receptors which interpret the impulses that allow one to recognize such sensations as pain, cold or a light touch
Term
4 Major brain region are
Definition

Cerebral hemispheres

Diencephalon

Brain stem

Cerebellum

Term
Cistern is
Definition
Enclosed space serving as a reservoir for cerebrospinal fluid
Term
Transducer should be utilized is
Definition
 7.5 MHz or higher
Term
Advantage over CT/MRI include:
Definition

Portability

Lower cost

Speed

No ionizing radiation and no sedation

Term
Sonography is essential for
Definition
New born, high risk, and unstable premature infant
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