Term
| List the two types of cell-mediated immunity which provide defense against intracellular pathogens |
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Definition
| Phagocytes (ingest microbes and kill) and Non-phagocytes (infected and killed by CTLs) |
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Term
| Explain the term "microbial parasites" |
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Definition
| bacteria, fungi, protozoa that resist phagocyte killing and live in vesicles in cytoplasm |
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Term
| differences between presentation of peptides derived from vesicles vs. cytoplasm |
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Definition
vesicles: peptide + MHC class II presented to CD4
Cytoplasm: peptide + MHC Classs 1 presented to CD8 cells |
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Term
| describe molecules involved in T cell migration and adherence to microbial-infected epithelium |
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Definition
On T cell: adhesion molecules and chemokine receptors
On endothelium: adhesion molecule ligands and chemokines -- expression increases after microbial exposure
chemokines = migration, adherence molecules = binding |
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Term
| Describe the molecules that are involved in the movement of naive T cells from high endothelial venules (HEV) into lymph nodes. |
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Definition
On T cell: adhesion molecules and chemokine receptors
On endothelium: adhesion molecule ligands and chemokines -- expression increases after microbial exposure
naive t cells are drawn into the lymph node via chemokine and chemokine receptor interactions |
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Term
| describe the molecules that are involved in the movement of activated T cells from the bloodstream into infected peripheral tissues. |
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Definition
same as HEV --> lymph nodes
On T cell: adhesion molecules and chemokine receptors
On endothelium: adhesion molecule ligands and chemokines -- expression increases after microbial exposure |
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Term
| explain why T cells other than T cells specific for the microbe-encoded antigen are allowed to enter peripheral sites of infection. |
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Definition
| none of the molecules involved in movement are Ag-specific; the modus operandi is to let all T-cells into the periphery, then sort out who needs to stay based on who adheres the best -- most adherence = most activated |
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Term
| compare and contrast the need for co-stimulation in the activation of naive T cells in the secondary lymphoid tissues and the effector function of activated T cell in infected peripheral tissues. |
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Definition
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Term
| describe the molecules that are involved in TH1 cell-mediated macrophage activation. |
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Definition
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Term
| list some of the molecules that are involved in killing phagocytosed microbes and how these molecules can contribute to immunopathology. |
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Definition
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