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21. Effector Mechs of Cell Immunity (Bonneau)
Mar 31
10
Immunology
Graduate
04/04/2011

Additional Immunology Flashcards

 


 

Cards

Term
List the two types of cell-mediated immunity which provide defense against intracellular pathogens
Definition
Phagocytes (ingest microbes and kill) and Non-phagocytes (infected and killed by CTLs)
Term
Explain the term "microbial parasites"
Definition
bacteria, fungi, protozoa that resist phagocyte killing and live in vesicles in cytoplasm
Term
differences between presentation of peptides derived from vesicles vs. cytoplasm
Definition
vesicles: peptide + MHC class II presented to CD4
Cytoplasm: peptide + MHC Classs 1 presented to CD8 cells
Term
describe molecules involved in T cell migration and adherence to microbial-infected epithelium
Definition
On T cell: adhesion molecules and chemokine receptors
On endothelium: adhesion molecule ligands and chemokines -- expression increases after microbial exposure

chemokines = migration, adherence molecules = binding
Term
Describe the molecules that are involved in the movement of naive T cells from high endothelial venules (HEV) into lymph nodes.
Definition
On T cell: adhesion molecules and chemokine receptors
On endothelium: adhesion molecule ligands and chemokines -- expression increases after microbial exposure

naive t cells are drawn into the lymph node via chemokine and chemokine receptor interactions
Term
describe the molecules that are involved in the movement of activated T cells from the bloodstream into infected peripheral tissues.
Definition
same as HEV --> lymph nodes

On T cell: adhesion molecules and chemokine receptors
On endothelium: adhesion molecule ligands and chemokines -- expression increases after microbial exposure
Term
explain why T cells other than T cells specific for the microbe-encoded antigen are allowed to enter peripheral sites of infection.
Definition
none of the molecules involved in movement are Ag-specific; the modus operandi is to let all T-cells into the periphery, then sort out who needs to stay based on who adheres the best -- most adherence = most activated
Term
compare and contrast the need for co-stimulation in the activation of naive T cells in the secondary lymphoid tissues and the effector function of activated T cell in infected peripheral tissues.
Definition
Term
describe the molecules that are involved in TH1 cell-mediated macrophage activation.
Definition
Term
list some of the molecules that are involved in killing phagocytosed microbes and how these molecules can contribute to immunopathology.
Definition
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