Term
4 major types of vegetative endocarditis |
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Definition
1. Infectious endocarditis 2. Acute Rheumatic Fever 3. Non-bacterial thrombotic (marantic) endocarditis 4. Endocarditis of SLE (Libman-Sacks disease) |
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Term
Non-bacterial thrombotic (marantic) endocarditis |
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Definition
Vegetation - collection of fibrin and peripheral blood elements along line of closure in normal valve leaflets Small, nondestructive, sterile Often seen in debilitated (cancer, sepsis) or hypercoagulable patients |
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Term
Chronic rheumatic aortic stenosis |
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Definition
The leaflets and cusps are thicker and are fused together |
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Term
Calcific (senile) aortic stenosis |
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Definition
Calcified masses grow inside the aortic cusps and protrude into the sinuses of Valsalva. Makes the aortic opening smaller. No commisurral adhesion or fusion of the cusps. |
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Term
The most common primary tumor of the heart in adults |
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Definition
Myxomas 90% in Atria - LA to RA being 4:1 Can obstruct valves, embolize, or cause constitutional symptoms (fever malaise) |
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Term
Most common primary tumor of the heart in children |
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Definition
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Term
Autosomal Dominant disease involving Myxomas |
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Definition
Carney's Syndrome (10% of Myxomas) - Multiple myxomas inside and outside the heart, spotty pigmentation and endocrine overactivity |
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Term
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Definition
Acute process that occurs in some individuals after Strep A pharyngitis. Probably caused by cross-reaction of Strep A antibodies to cardiac antigens. Rash, fever, acute carditis, polyarthritis, subcutaneous nodules, and chorea |
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Term
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Definition
Long term sequelae of rheumatic fever. Valvular scarring. Classically characterized by mitral stenosis. Most common cause of acquired mitral stenosis. Increased risk for infectious endocarditis. |
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Term
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Definition
Circumscribed collections of mononuclear inflammatory cells with central necrosis, including large cardiogenic histiocytes with prominent nucleoli (Aschoff cells) Seen in Acute rheumatic carditis pathognomonic for rheumatic fever |
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Term
Valves most commonly involved in Chronic Rheumatic Heart Disease |
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Definition
Mitral Valve alone (65-70%) Mitral and Aortic (25%) tricuspid and/or pulmonic - less common |
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Term
Acute Infectious Endocarditis |
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Definition
Staph Aureus Necrotizing, ulcerative, invasive valvular infections Death in days to weeks Occurs in previously healthy heart |
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Term
Subacute Infectious Endocarditis |
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Definition
Strep viridans Less destructive, some healing takes place Occurs in abnormal hearts progress over many months |
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