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14.Varicella - Zoster Virus
Finished
11
Bible Studies
Graduate
12/15/2008

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Term
Varicella Zoster Virus
Definition

-capsid w/ double stranded DNA

-from the herpese viridae family

 

Causes two distinct infections:

 

Chicken pox and Herpes Zoster (shingles)

Term
Spread of Varicella Zoster
Definition

-virus enters via nasopharynx

 

Primary viremia - spreads to lymph nodes, liver and spleen

 

Secondary viremia - from liver and spleen to skin and other regions (like nerves)

 

Term
Chicken Pox
Definition

Caused by Varicella Zoster virus

Hallmark are skin lesions starting on trunk and moving outwards

 

-highly contagious

-patients are infectious 48 hours before onset of rash

Term
Latent Varicella Zoster
Definition

-found in 90% of the population

-those over 60 are most susceptible to reactivation

Term
Complications of Varicella Zoster
Definition

-secondary bacterial infections (stre. pyogenes of staph aureus)

 

-meningeal irritation seen 21 days after onset of chickenpox in children

Term
Herpes Zoster Reactivation
Definition

aka. Shingles

 

-reactivation of latent VZV that usually occurs in 6th to 8th decades of life

-unilateral eruption within a dermatome (often with severe pain)

 

eg. only one side of face is affected

-infection of trigeminal nerve often involves the face

Term
zoster ophthalmicus
Definition
infection of ophthalmic branch of trigeminal nerve with Varicella Zoster
Term
prophylaxis
Definition
when drugs are administered to prevent a disease (or in secondary prophylaxis, to prevent the worsening of the condition)
Term
Administration of prophylaxis measures for Herpes Zoster
Definition
administration of zoster immune globulin (ZIG) or VZIG should be given within 72 hours (and up to 96 hours) of infection
Term
treatment of Herpes Zoster
Definition

Oral Acyclovir

famciclovir

Pain releivers

 

Note:  No asprin for those under 19 because it can cause Reys syndrom where fatty degeneration of the liver and encephalitis occurs.

Term
Organisms that Cross the Placenta
Definition

ToRCHeS

 

TOxoplasmosis

Rubella

Cytomegalovirus

HErpes and HIV

Syphillis

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