Term
| ___ are major players in the inflammatory response |
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Definition
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Term
| Arachidonic acid is created by the breakdown of ... by ... |
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Definition
| membrane phospholipids by phospholipase |
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Term
| Arachidonic acid is a substrate for the cyclooxygenase enzyme. What are the products of this reaction? |
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Definition
| Prostaglandins and Thromboxanes |
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Term
| If you want to target prostaglandin production, what do you target? |
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Definition
phospholipase enzyme
the cyclooxygenase enzyme |
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Term
| What does NSAID stand for? |
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Definition
| non-steroidal anti-inflammatory drugs |
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Term
| What kind of NSAIDs are there? (generally) |
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Definition
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Term
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Definition
| acetylsalicylic acid aka Aspirin |
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Term
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Definition
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Term
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Definition
- decreased levels of prostaglandin produced
- decreased inflammatory response |
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Term
| With ASA, is the effect on platelet function reversible or non-reversible? |
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Definition
It is non-reversible! It prevents platelet function even at low doses.
Very difficult to stop bleeding when taking aspirin |
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Term
| Why does ASA have a greater effect on the gut and kidney function than other NSAIDs? |
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Definition
| because it has higher Cox-1/Cox-2 ratio of inhibition than the others |
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Term
| What are some trade names for ibuprofen? |
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Definition
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Term
| Is the effect of ibuprofen on platelets reversible or non-reversible? |
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Definition
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Term
| What are some benefits of naproxen? |
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Definition
- It has a long half-life (14 hours... good for dosing)
- Reduced GI impact compared to ASA
- it is available OTC in Canada |
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Term
| Insert cards on important side effects on tissues |
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Definition
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Term
| What type of Cox does Celebrex inhibit? |
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Definition
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Term
| Acetaminophen/Paracetamol is primarily a ___ __ rather than an anti-inflammatory |
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Definition
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Term
| Acetaminophen has limited Cox inhibitor activity but effects the ___ ___ ___ to provide pain relief |
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Definition
| endogenous cannabinoid system |
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Term
| What would be a better choice for pain and fever in children? (ASA or Acetaminophen) |
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Definition
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Term
| What are the outcomes of overdose of acetaminophen? |
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Definition
- serious (potentially fatal) liver damage
- exacerbated by chronic alcohol use
- Acetaminophen has a small therapeutic window |
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Term
| What is an example of a steroidal anti-inflammatory drug we talk about often? (think transplants) |
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Definition
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Term
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Definition
| a drug that is administered in its inactive form, but them becomes activated through a normal metabolic process |
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Term
| Prednisone is a pro-drug... It gets converted to ____ in the liver |
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Definition
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Term
| How does prednisone block prostaglandins? |
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Definition
| by blocking phospholipase A2 |
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Term
| At high levels of prednisone, what type of cells tend to be depleted? |
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Definition
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Term
| With use of prednisone, is differentiation increased or decreased? |
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Definition
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Term
| Prednisone target transcription of ... |
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Definition
- cytokines from T cells
- inflammatory cells (such as TNF and IL-1 from macrophages) |
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Term
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Definition
another steroidal anti-inflammatory drug that is more potent than prednisone (though it has a similar mode of action)
- can be given topically, orally or by injection |
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Term
| Drugs that end in -mab, are what kind of drugs? |
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Definition
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Term
| How does Remicade (an anti-inflammatory antibody) work? |
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Definition
| It binds directly to TNF and blocks the pro-inflammatory effects |
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Term
| What type of domain does a TCR have? |
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Definition
| a transmembrane domain (no intracellular domain) |
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