Term
| Most important prog factor with sarcoma devoid of systemic mets |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Definition
| Testicular, choriocarcinoma |
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Term
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Definition
HIGHEST sensitivity
-low specificity |
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Term
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Definition
small cell lung CA
Neuroblastoma |
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Term
| Gene w/thyroid medullary CA |
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Definition
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Term
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Definition
CEA = 18 d
PSA = 18 d
AFP = 5d |
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Term
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Definition
Latency period = time between exposure and formation of detectable tumor
1. initiation
2. promotion
3. progression |
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Term
| proto-oncogene definition |
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Definition
| HUMAN gene with malig potential |
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Term
| Most vulnerable stage of cell cycle to XRT? |
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Definition
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Term
| What causes damage due to XRT? |
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Definition
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Term
| What tissues does higher energy radiation most affect? |
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Definition
Deeper tissues (Skin preserving)
-doesn't reach full ionizing potential until deeper- |
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Term
| Benefit of fractionate XRT doses? |
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Definition
-allows repair of normal cells
-allows re-oxygenation of tumor
-allows re-distribution of tumor cells in cell cycle |
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Term
| What makes a tumor radiosensitive? |
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Definition
high mitotic rate
-seminoma, lymphoma |
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Term
| Examples of radio-resistant tumors |
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Definition
epithelial
sarcomas
-Large tumors (due to lack of O2 in the tumor) |
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Term
| tumor killing pattern of cell cycle-specific vs non specific agents? |
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Definition
-cycle-specific have plateau in killing
-non-spec = linear response to cell killing |
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Term
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Definition
microtubule stabilization that can't be broken down
-SE = neuropathy |
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Term
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Definition
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Term
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Definition
neprho, neuro, ototoxic
(platinum alkylating agent) |
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Definition
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Term
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Definition
microtubule inhibitor
-Peripheral neuropathy, neurotoxic |
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Term
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Definition
MIcrotubule inhibitor
-Myelosupression |
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Term
Cyclophosphamide
-active metab?
-SE? |
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Definition
alkylating agent (acrolein = active metab)
-SE = gonadal dysfunction, SIADH, hemorrhagic cystitis
(Mesna vs hem cystitis) |
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Term
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Definition
| anit-helminthic drug with immune stimulating function used vs cancer |
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Term
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Definition
1. Inhib di-hydrofolate reductase, which inhibs purine and DNA synthesis
2. SE = Renal tox, radiation recall
3. Leucovorin rescue (folinic acid) reverses MTX effects by giving folate |
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Term
5FU
mech
-factor that inc tox? |
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Definition
1. inhib thymidylate synthase, which inhibs pruine DNA synth
2. Leucovorin (folinic acid) = inc toxicity |
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Term
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Definition
1. DNA intercalator, O2 rad formation
2. Heart tox 2/2 O2 radicals |
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Term
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Definition
| inhibits topoisomerase (DNA unwinding enz) |
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Term
| Chemo agents with lease myelosuppression |
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Definition
bleomycin
vincristine
busulfan
cisplatin |
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Term
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Definition
1. Neurtrophil recovery after chemo
2. SE - Sweet's syndrome (acute febrile neutropenic dermatitis) |
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Term
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Definition
Tumor suppressor
-retinoblastoma |
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Term
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Definition
tumor suppressor
-normally induces apoptosis |
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Term
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Definition
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Term
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Definition
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Term
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Definition
tumor supressor
(apop regulator) |
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Term
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Definition
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Term
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Definition
Proto-oncogene
-Gprotein defect @ GTPase |
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Term
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Definition
proto-oncogene
-Tyrosine kinase defect |
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Term
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Definition
proto-oncogene
-platelet derived growth factor receptor defect |
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Term
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Definition
proto-oncogene
-epidermal growth factor receptor defect |
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Term
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Definition
proto-oncogene
-transcription factors |
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Term
Li-fraumeni syndrome
-gene
-assoc ca |
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Definition
p53
-childhood sarcomas,
-breast
-brain
-leukemia
-Adrenal CA |
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Term
| Genes implicated in colon CA |
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Definition
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Term
| Initial gene implicated in coloni CA |
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Definition
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Term
Carcinogen and assoc CA
-Coal tar
-beta naphthylamine
-Benzene
-Asbestos |
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Definition
-larynx, skin, bronchial CA
-urinary tract (bladder) Ca
-Leukemia
-Mesothelioma |
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Term
| origin of suspicious peri-umbo node |
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Definition
| pancreas (sister mary joe) |
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Term
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Definition
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Term
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Definition
Breast = #1
-also prostate |
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Term
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Definition
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Term
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Definition
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Term
| Phases of clinical trials |
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Definition
1 = safe and at what dose?
2 = effective?
3 = better than current therapy?
4 = implementation/marketing |
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Term
| prognostic factors after resection of colorectal to hepatic mets? |
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Definition
-disease free > 12 mo
-tumor # < 3
-CEA < 200
- Size < 5 cm
- neg nodes |
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Term
| Most successfully cured metastatic dz w/surgery? |
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Definition
Germ cell tumor
-#1 = seminoma (75% 5YSR) |
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Term
| MC source of mets to bone |
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Definition
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Term
| MC source of mets to skin |
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Definition
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Term
| MC source of mets to lung |
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Definition
breast
(contralat lung in males) |
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Term
| MC source of mets to breast |
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Definition
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Term
| MC source of mets to small bowel |
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Definition
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Term
| MC source of mets to liver |
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Definition
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Term
| MC source of mets to spleen |
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Definition
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Term
| MC source of mets to ovary |
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Definition
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Term
| MC source of mets to brain |
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Definition
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Term
| MC source of mets to heart |
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Definition
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Term
| MC source of mets to adrenal |
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Definition
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Term
| list the alkylating agents |
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Definition
1. -platins (cis, carbo, oxali)
2. cyclophosphamide
3. Busulfan
4. Streptozocin
5. Dacarbazine |
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Term
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Definition
vs metastatic melanoma
-often single agent |
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Term
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Definition
pancreatic islet cell tumor
-glucose mimic @ islet cells |
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Term
S phase agents
-types/list |
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Definition
1. anti-metabolites (MTX, 5FU, Gemcitabine, Pemetrexed)
2. Toposiomerase inhibitors (etoposide, topotecan)
3. Anti-tumor abx (doxorubicin (adriamycin)). |
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