Term
| typical syphilis patient= |
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Definition
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Term
| How long after innoculation does it take before you get a chancre? |
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Definition
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Term
| When do you develop LAD with primary syphilis? |
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Definition
| 7-10 days after chancre appears |
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Term
| Without treatment, chancre and enlarged nodes will heal within _____. |
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Definition
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Term
| Describe the rash of secondary syphilis. |
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Definition
| non-pruitic red rash of varying severity, including palms and soles. Disappears without treatment and without scarring |
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Term
| What CNS problems are present in secondary syphilis? |
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Definition
| treponemes in the CNS may lead to symptomatic meningitis |
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Term
| How long is the latent period before you get tertiary syphilis? |
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Definition
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Term
| What are the symptoms/physiology of neurosyphilis? |
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Definition
| dementia, change in personality, psychotic episodes, demylinating disease |
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Term
| When do teponemes cross the placenta? |
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Definition
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Term
| What are the symptoms of babies that survive congenital syphilis? |
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Definition
| suffer interstitial keratitis (blindness), malformed teeth, facial deformation (saddle nose), and a host of CNS abnormalities |
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Term
| Where in the body can spirochetes be found in a person with syphilis? |
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Definition
| primary and secondary lesions, blood, CSF |
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Term
| What does syphilis look like cultured on agar? |
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Definition
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Term
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Definition
| rapid plasma reagin= mix of IgM/IgG antibodies against cardiolipin-lecithin-cholesterol |
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Term
| How long before you have serum positivity for RPR test? |
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Definition
| 2-3 weeks of untreated disease |
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Term
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Definition
| can be made quantitative, subject to false positives |
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Term
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Definition
killed T. pallidum + pt's serum + labeled anti-human Ig
killed spirochetes glow= a positive |
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Term
| Pros and cons of FTA-ABS? |
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Definition
| very specific and sensitive, but useless to evaluate treatment effectiveness |
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Term
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Definition
| treponema palldium-particles agglutination test; similar principle to FTA-ABS where a positive test is a mat of agglutinated particles |
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Term
| What are the pros/cons of TP-PA test? |
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Definition
| high sensitivity and specificity |
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Term
| How do you treat syphilis? |
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Definition
| penicillin or tetracyclines |
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Term
| How is syphilis prevented? |
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Definition
| notifiable disease by law, contact all sexual partners and treat, condom use |
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Term
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Definition
| endoflagella(axial filament), that allows it to move through viscous material like a corkscrew through cork |
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Term
| T/F Humans are the only host for T. pallidum |
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Definition
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Term
| At what stages of syphilis are you infective? |
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Definition
| primary and secondary syphilis (in tertiary you are seropositive but not infectious) |
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Term
| How can you grow syphilis in the lab? |
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Definition
| in rabbits (don't develop progressive disease) |
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Term
| What strain of T. pallidum is used in FTA-ABS tests? |
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Definition
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