Term
| What is the normal cellularity of the bone marrow? |
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Definition
| 50/50 (50% cells, 50% fat) |
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|
Term
| What is a normal M:E ratio? |
|
Definition
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Term
| Where does hematopoiesis take place throughout gestation? |
|
Definition
| yolk sac until 3rd month, then liver/spleen/thymus until 6 months, then lymph nodes and thymus |
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Term
| What are normal non-hematopoietic cells in the bone marrow? |
|
Definition
| osteoblasts, osteoclasts, histiocytes, adipocytoes, few lymhpocytes or plasma cells |
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Term
| What are abnormal non-hematopoietic cells in bone marrow? |
|
Definition
| metastatic tumor, granulomatous inflammation, proliferating fibroblasts, many lymphs or plasma cells |
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|
Term
| Where do you perform bone marrow aspiration in adult? |
|
Definition
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|
Term
| Where do you perform bone marrow biopsy in adults? |
|
Definition
|
|
Term
| Where do you perform bone marrow aspiration/biopsy in pediatric patients? |
|
Definition
|
|
Term
| Which long bones of the adult contain red bone marrow? |
|
Definition
| proximal portions of the humerous and femur |
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|
Term
| What are indications for bone marrow exam? |
|
Definition
| unexplaned anemia, leukocytopenia, unexplained leukocytosis, thrombocytopenia, thrombocytosis, immature cells in peripheral blood, some solid neoplasms (lymphoproliferative disease), fever of unknown origin, hereditary storage diseases, to monitor chemotherapy |
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Term
| What can substitute for a bone marrow biopsy? |
|
Definition
| clot section of a bone marrow aspirate |
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|
Term
| What information can you get from a bone marrow aspirate? |
|
Definition
| cellular monolayer, cellular morphology, nuclear and cytologic detail, M:E Ratio |
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|
Term
| What information can you get from a bone marrow biopsy? |
|
Definition
| retention of in vivo relationships, cellularity, non-hematopoietic elements |
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|
Term
| What special studies can you get on bone marrow? |
|
Definition
| special stains, flow cytometry, chromosome analysis |
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