Term
| What is the age of onset for bipolar d/o? |
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Definition
| 1/3 in childhood, 1/3 in teen years, 1/3 as adult |
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Term
| What's the difference between BP I and BP II? |
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Definition
BP I: more common; men = females
BP II: higher mortality/morbidity d/t suicide; less common; more common in women |
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Term
| What are the criteria for mania? |
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Definition
| elevated mood + 3 other criteria or irritable + 4 other criteria |
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Term
| How long do depressive symptoms have to last for a dx of bipolar d/o? |
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Definition
|
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Term
| what's the term that describes a person whose mood is constantly going up and down? |
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Definition
|
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Term
| Do antidepressant cause iatrogenic mania in patients with clinical depression? |
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Definition
| only when the patient is genetically predisposed, i.e. has a first degree relative with bipolar d/o |
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Term
| When patients only recall times they felt the way they do currently = |
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Definition
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Term
| The difference between flight of ideas associated with ADHD and the flight of ideas associated with bipolar d/o is... |
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Definition
| FOI with ADHD has evident since age 6 and is associated with a normal mood |
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Term
| Treatment for what diseases can exacerbate mania? |
|
Definition
|
|
Term
| What three classes of drugs are used to treat bipolar d/o? |
|
Definition
| lithium, anticonvulsants, antipsychotics |
|
|
Term
| Name the antipsychotics proven to prevent mania? |
|
Definition
| valproate, carbamezepine, lamotrigine |
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Term
| Which anticonvulsant is "loadable"? |
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Definition
|
|
Term
| What drug used to treat bipolar d/o induces its own metabolism? How? |
|
Definition
| carbemzepine, induces CYP 3A4 |
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|
Term
| How is lithium carbonate excreted? |
|
Definition
| renal excretion (or dialysis); no metabolism |
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Term
| Lithium can reach dangerous levels and cause comas if paired with which other drug? |
|
Definition
|
|
Term
| How does lithium carbonate stabalize mood? |
|
Definition
| decreases catabolism and decreases reuptake of GABA |
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|
Term
| What type of bipolar d/o is best treated with lithium carbonate? |
|
Definition
| euphoric mania and <4 cycles a year |
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Term
| What teratogenic effects are associated with lithium carbonate use during pregnancy? |
|
Definition
| Ebstein's abnormality, an abnormality of the tricuspid valve (during first trimester) |
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Term
| Which anticonvulsant has a therapuetic level close to the toxicity level? |
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Definition
|
|
Term
| What are the teratogenic effects of valproate? |
|
Definition
|
|
Term
| If a patient is taking valproate and there is a possibility she could get pregnant she should also be taking... |
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Definition
|
|
Term
| What are some side affects of valproate? |
|
Definition
| pancreatitis, polycycstic ovary syndrome (not dz), patchy alopecia |
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|
Term
| What is the toxic metabolite caused by carbamozepine metabolism? |
|
Definition
|
|
Term
| What are teh teratogenic affects of carbamozepine? |
|
Definition
|
|
Term
| What are the pros and cons of using Lamotrigine? |
|
Definition
| no known therapeutic serum elevel so not blood tests are needed; associated with Stevens Johnson's syndrome. WEIGHT NEUTRAL! |
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|
Term
| What are the pros and cons of using 2nd generation antipsychotics to treat bipolar d/o? |
|
Definition
| no weight gain or cognitive dulling; associated with hyperglycemia |
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