Term
| Mnemonic for remembering purines and pyrimidies |
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Definition
| Pure silver (Purines A and G) |
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Term
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Definition
Individual nucleotides are connected by
phosphodiester linkages. Phosphodiester “backbone” links 5’ carbon to 3’ carbon
of adjacent nucleotides. |
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Term
| Is DNA left or right handed helix? How many bp per turn? |
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Definition
| Right handed helix, approx 10 bp per turn |
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Term
| Effect of putting DNA and RNA in aqueous conditions |
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Definition
| RNA broken up because of 2' OH. DNA is not broken up because it does not have a 2' OH> |
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Term
| Anti-retroviral dideoxynucleosides |
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Definition
These molecules carry no 2’ OR 3’ hydroxyl groups, so if incorporated into a growing DNA chain (2’ deoxy), they will automatically “terminate” it (3’ deoxy) – thus they are reverse transcriptase inhibitors.
AZT and 3TC combined in “Combivir” – combination drugs now very common in HIV treatment, and often include inhibitors of other HIV life-cycle stages as well |
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