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090114 - Virus Symptoms
Match symptoms to disease
53
Immunology
Graduate
09/01/2014

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Cards

Term
Rhinovirus
Definition
Nasal congestion, sneezing, sore throat, headache, cough, sometimes fever. Diagnostics not usually done
Term
Human Coronavirus
Definition
Nasal congestion, sneezing, headache. NO fever, coughing & sore throat RARE. Diagnostics not usually done
Term
SARS
Definition
Like rhinovirus, also extensive pneumonia. Diagnosed by RT-PCR, ELISA, and viral culture
Term
Adenovirus
Definition
Fever, sore throat, red eye (can have wide range of other illnesses but eye involvement typical). Diagnosed by immunofluorescence, virus isolation, or observing cytopathic effect (cpe)
Term
Influenza (A, B)
Definition
Abrupt (2-3d) onset of shivering, malaise, headache, HIGH fever, myalgia, backache, patient MUST REST; sore throat often, runny nose possible. Immunofluorescence and ELISA can be used
Term
Measles
Definition
Prodrome (first 2-3d): Runny nose, coughing, HIGH fever, whitish-blue Koplik spots around mouth mucosa. Then, maculopapular rash spreading from face to limbs. Dx - ELISA titers
Term
Subacute Sclerosing Panencephalitis (SSPE)
Definition
Problems with motility and behavior due to demyelination and neuronal degeneration; nearly 100% fatal. Onset is many years after measles
Term
Mumps
Definition
2-3 weeks of incubation, malaise, low fever, parotid swelling. Can also see orchitis (swollen testicle), meningitis, or encephalitis. Dx by culture or IgM ELISA
Term
Respiratory Syncitial (RSV)
Definition
Common cold with significant rhinorrhea, EXPIRATORY WHEEZES. Dx by syncitia observed in histology, or indirect immunofluorescence
Term
Parainfluenza (PIV)
Definition
Common cold with rhinorrhea, wheezes, low fever, croup cough.
Term
Rubella (German Measles)
Definition
14-16d incubation; mild febrile illness, low fever, enlarged lymph nodes; DISCRETE pink rash 1-2d after incubation. Dx by ELISA IgG test
Term
Congenital rubella syndrome
Definition
If fetus reaches term, baby is born with low birth weight, CV & CNS defects, liver enlargement, sight, hearing, bone defects, insulin-dependent diabetes, MRDD
Term
Varicella (Chickenpox)
Definition
Low fever, itchy spotted rash, worse in adults. Maculopapular rash --> vesicle --> pustular --> crusts --> scars
Term
Human Bocavirus
Definition
Cold symptoms + diarrhea, conjunctivitis, rash
Term
Human Metapneumovirus
Definition
Paramyxovirus resembling RSV and PIV: Common cold with significant rhinorrhea
Term
Rotavirus
Definition
Acute viral gastroenteritis symptoms with 2 day onset; mainly severe diarrhea, esp. in young children. Peaks in winter
Term
Adenovirus 40 & 41
Definition
Acute viral gastroenteritis in infants. Dx by ELISA, RT-PCR, or Immune EM
Term
Caliciviruses (Norwalk)
Definition
Acute viral gastroenteritis in older children and adults, with diarrhea, vomiting, nausea, abdominal cramps, headache, fever, malaise. Dx by ELISA or RT-PCR
Term
Astrovirus
Definition
Diarrhea outbreaks in children. Peaks in winter. Dx by ELISA
Term
Poliovirus
Definition
Most cases asymptomatic. <1% of cases exhibit asymptommatic flaccid paralysis or bulbar paralysis
Term
Cosavirus
Definition
Associated with diarrhea and acute flaccid paralysis; second most common human enteric infection (common stool-associated)
Term
Coxsackie
Definition
Two groups of serotypes; A - herpangina (vesicles in mouth), hand, foot, mouth disease (vesicles), congenital heart disease, aseptic meningitis. B - pleurodynia (epidemic myalgia), acute infectious myocarditis, acute pericarditis
Term
ECHO (Enteric Cytopathogenic Human Orphan)
Definition
Similar to Coxsackie but less severe
Term
Enteroviruses 68-71 (specifically 70, 71)
Definition
70 - acute hemmorhagic conjunctivitis. 71 - hand, foot, mouth; also brain infections in young children
Term
B19 Parvovirus
Definition
Mild fever or cold for a few days, then "slapped cheek" rash breaks out. If adult is infected, polyarthropathy may be present which mimics rheumatoid arthritis. Transient aplastic crisis may occur in patients with underlying hemolytic disorder; pure red cell aplasia/chronic anemia may occur in patients with immune concerns. Hydrops fetalis (death in utero) in fetal infection. Dx by PCR, ELISA, observing IgM Abs to B19
Term
Bocavirus
Definition
Acute respiratory tract infections in infants/children; most likely in winter/early spring
Term
JC (Polyoma)
Definition
Infects oligodendrocytes and prevents myelination of neurons; found in patients with progressive multifocal leukoencephalopathy
Term
BK (Polyoma)
Definition
Mild respiratory illness, affects kidneys
Term
Papilloma 1, 2, 3, 4, 10, 57
Definition
Non-cancerous verrucae (plantar, common, flat warts)
Term
Papilloma 6, 11
Definition
Anogenital, larynx warts, low cancer risk
Term
Papilloma 16, 18
Definition
Flat condylomata, dysplasias, carcinoma of anogenital or esophagus; high cancer risk
Term
Papilloma 5, 8, 47
Definition
Epiderodysplasia verruciformis at the face, trunk, esophagus; very high cancer risk
Term
Variola (smallpox)
Definition
Prodrome with high fever, followed by oropharyngeal enanthem, skin rash (exanthem). Rash progresses to pustules that feel like they contain birdshot; pustules progress to scabs and pitted scars. Dehydration usually causes death
Term
Herpes simplex virus 1/2
Definition
Oral and genital blisters, can also occur in pharynx, conjunctiva, finger, skin. Type 1 - above waistline, Type 2 - below waistline. Fetal infection often fatal. Type 2 can develop into encephalitis. Dx with Tzanck smears, showing "ballooned" cells and syncitia with cowdry NUCLEAR inclusion.
Term
Shingles (Herpes Zoster)
Definition
Initial infection: 2 wk incubation, fever, maculopapular rash --> vesicle --> pustules --> crusts --> scabs. Characteristic band pattern in trunk. Area becomes painful to touch and skin breaks with vesicles. Dx with cowdry NUCLEAR inclusions and syncitia in Tzanck smears, ELISA PCR
Term
Herpes virus B (Monkey virus)
Definition
Infection may be unapparent, or result in vesicular lesions, transmission by bite can lead to fatal encephalomyelitis
Term
Cytomegalovirus
Definition
Fetal: Many birth defects, rash. Adults: infectious mononucleosis, prolonged fever, mild hepatitis. Immunocompromised: pneumonia, retinitis, colitis. Dx by ELISA, IgM or IgG. Histology shows "owl's eye" nuclear inclusions
Term
Roseola (HHV6)
Definition
High fever and short lived, generalized rash
Term
HHV7
Definition
Mononucleosis and lymphadenopathy
Term
Infectious mononucleosis (Epstein Barr Virus)
Definition
Fatigue, lymphadenopathy, exudative pharingitis, splenomegaly, hepatomegaly (FLESH). Fever frequent, rash possible. Life-threatening in immunocompromised patients. Dx by lymphocyte counts, Downey cells, heterophile antibody, presence of early antigen (EA), viral capsid antigen (VCA), nuclear antigens (EBNA), membrane glycoproteins (MA)
Term
Kaposi sarcoma-associated herpesvirus (HH8)
Definition
Pneumonia, skin lesions, can cause tumors. Dx by symptoms, PCR, serology
Term
West Nile Virus
Definition
Most cases start asymptomatic, develop into fever/headache, rash, meningitis, encephalitis (rare: acute flaccid paralysis, poliomyelitis). Dx by history, histology of brain tissue
Term
St. Louis Encephalitis
Definition
Similar symptoms to West Nile
Term
Dengue Fever
Definition
Fever, headache, retro-orbital pain, myalgia/arthralgia, bone-ache (breakbone fever), rash, flu-like (rare: encephalitis).
Term
Dengue Hemorrhagic Fever
Definition
Hemorrhages, plasma leakage, hypotension, fluid accumulation in lungs, circulatory failure, shock
Term
Yellow Fever
Definition
Hemorrhagic fever with jaundice, degeneration of liver, kidney, heart. 50% mortality
Term
Chikungunya
Definition
Fever, headache, rash, joint pain
Term
Sin Nombre (Hantavirus Pulmonary Syndrome)
Definition
Early: fever, headaches, muscle aches, stomach problems, dizziness, chills. Late: fluid-filled lungs, shortness of breath
Term
Hantaan, Ruumala
Definition
Hemorrhagic fever with renal syndrome
Term
Lassa, Machupo, Junin
Definition
Hemorrhagic fever: flushing, petichiae, edema, hypotension, capillary leak, shock, malaise, myalgia, vomiting, diarrhea
Term
Lymphocytic choriomeningitis virus (LCMV)
Definition
Encephalitis (Arenavirus)
Term
Rabies
Definition
Fever, headache, malaise, encephalitis, nausea, vomiting, hydrophobia, confusion, hallucinations, respiratory failure, death. Incubation over 2 wks - 18 mo. Dx: bullet-shaped appearance, Negri Bodies (CYTOPLASMIC inclusion bodies)
Term
Ebola/Marburg
Definition
Hemorrhagic fever
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