Term
|
Definition
Inhibition of MAO-B: Rasagiline (Azilect), Selegiline (Anipryl)
Inhibition of COMT: Entacapone (Comtan), Tolcapone (Tasmar)
MAO and COMT degrade dopamine
Ropinirole (Requip) is a Potent D2,3 receptor agonist
Pramipexole (Mirapex) is a Potent D3, 2, 4 receptor agonist
Carbidopa/Levodopa
avoid Tramadol and opioids |
|
|
Term
|
Definition
Olanzapine (Zyprexa): diabetes
Risperidone (Risperdal)
Quetiapine (Seroquel)
Ziprasidone (Geodon)
Clozapine (Clozaril): black box warning for agranulocytosis
Aripiprazole (Abilify): Partial agonist activity at dopamine and serotonin 5-HT 1A receptors and antagonist activity at 5-HT2A receptors
Interact with any drug that causes CNS depression—benzos, opiates, ethanol, antihistamines |
|
|
Term
|
Definition
Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Paxil)
Citalopram (Celexa)
Escitalopram (Lexapro)
avoid aspirin and NSAIDs |
|
|
Term
| Venlafaxine (Effexor) and Duloxetine (Cymbalta) block |
|
Definition
both serotonin and norepi reuptake
avoid NSAIDs, epi with caution, dry mouth |
|
|
Term
| Bupropion (Wellbutrin) blocks |
|
Definition
norepi and dopamine reuptake
Weakly blocks serotonin reuptake
avoid NSAIDs, epi with caution, dry mouth |
|
|
Term
| Sodium channel inhibitors |
|
Definition
Valproic Acid (Depakote)
Topiramate (Topamax)
Carbamazepine (Tegretol)
Phenytoin (Dilantin) |
|
|
Term
| NSAIDS reduce the antihypertensive effects of |
|
Definition
| β-blockers, diuretics, ACE inhibitors |
|
|
Term
|
Definition
Memantine (Namenda), Amantadine (Symmetrel)
Alzheimer’s |
|
|
Term
|
Definition
|
|
Term
| Cyclosporin toxicity can be caused by |
|
Definition
Cipro, Bactrim and azole's
leads to kidney failure |
|
|
Term
| digoxin toxicity can be caused by |
|
Definition
itraconazole, erythromycin and clarithromycin
cardiac arrhythmia |
|
|
Term
| Lithium toxicity can be caused by |
|
Definition
NSAIDs decrease lithium excretion
kidney failure, seizure |
|
|
Term
| Methotrexate toxicity can be caused by |
|
Definition
| NSAID's, salicylates, and penicillin |
|
|
Term
| Phenytoin toxicity can be caused by |
|
Definition
|
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