Term
| lyte abx w/massive transfusion |
|
Definition
hypoCa
*blood stored in citrate, binds Ca* |
|
|
Term
PRBC
-storage life
-changes w/storage |
|
Definition
3 weeks
-dec 2,3 DPG, pH,
-inc K+, lactic acid |
|
|
Term
|
Definition
| 6 pk PLT = 50,000 PLT increase |
|
|
Term
PLT transfusion w/out appropriate response
-mgmt |
|
Definition
-try ABO matched PLT
...still low?
-check HLA ab / HLA matched PLT |
|
|
Term
| Effects of massive transfusion |
|
Definition
dec Ca
dec coagulation factors
dec temp |
|
|
Term
Cryoprecipitate
-what factors does it contain? |
|
Definition
highest levels of vWF, fibrinogen,
Factor 8,
F13 |
|
|
Term
|
Definition
vWD
low fibrinogen bleeding |
|
|
Term
| use of irradiated blood prodcuts |
|
Definition
pts w/GVHD risk
-kills T cells- |
|
|
Term
|
Definition
chronically transfused pts,
pts awaiting txp
hx non hemolytic reacion
*clears WBCs, which cause HLA allo-immunization, fever, and carry CMV* |
|
|
Term
|
Definition
Febrile non-hemolytic
1:100 |
|
|
Term
Febrile non-hemolytic transfusion reaction
-sx
-path
tx |
|
Definition
-Fever/rigors 0-6 hrs after transfusion
-Preformed recip Abs vs donor WBCs = cytokine release
-STOP transfusion, Tyl, leukoreduced blood next time |
|
|
Term
Allergic TF reaction
-Sx
-path
-tx |
|
Definition
-urticaria, rare anaphylaxis
-IgA deficient pt (have Abs to IgA) receive IgA blood
- tx = benadryl/H2 blockers, epi if anaphylaxis |
|
|
Term
Delayed hemolytic TF reaction
-sxs
-path
-tx |
|
Definition
-minimal sx (fever, jaund, hct drop) 5-10 days AFTER TF
-path = recip Abs vs donor minor RBC antigen (HLA)
-tx supportive |
|
|
Term
|
Definition
-hypoxia, diffuse alveolar infiltrates, fever, non cardio pulm edema
-donor Abs vs recip WBCs-->lodge in lung + inc cap perm
*< 6 hrs after TF*
-tx like ARDS |
|
|
Term
Acute hemolytic TF reaction
-sxs
-path |
|
Definition
-fever/hypoTN, tachy, flank pain, hematuria
-->renal failure, DIC, shock
-ABO incompat (preformed recip Ab vs donor RBCs) |
|
|
Term
Acute hemolytic TF reaction
-dx |
|
Definition
-Haptoglobin < 50
-Free Hgb > 5
-inc unconj bili |
|
|
Term
Acute hemolytic TF reaction
tx |
|
Definition
STOP TF
-resuscitation
-Diuretics
-bicarb |
|
|
Term
| Frequency of different transfusion reactions |
|
Definition
1. febrile non-hemo 1:100
2. allergic 1:150
3. delayed hemolytic 1:2500
4. TRALI 1:15,000
5. Acute hemolytic 1:250,000
6. Fatal 1:500,000 |
|
|
Term
| MCC death from transfusion |
|
Definition
| Clerical error w/ABO incompatibility |
|
|
Term
Infectious complications of transfusion
-frequency |
|
Definition
1. bacterial (PLT) 1: 50K
2. Bacterial (RBC) 1: 500 K
3. Hep B 1: 200 K
4. Hep C 1: 2 mill
5. HIV 1: 2 mill |
|
|
Term
| MC blood product with bacterial contamination |
|
Definition
PLT
-stored at room temp (last 5 days)
-cold storage = dec half life |
|
|
Term
| MC blood product contaminant |
|
Definition
|
|
Term
| % that develop anti-PLT abs after transfusion? |
|
Definition
| 20% after 10-20 plt transfusion |
|
|
Term
| What blood prod don't carry HIV or hep risk? |
|
Definition
albumin
Immunoglobulins
**Are heat treated** |
|
|
