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Embryology of domestic animals
Embryology of domestic animals
137
Veterinary Medicine
Not Applicable
11/13/2011

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Cards

Term
What are the four stages of development in the lungs?
Definition
1. Pseudoglandula
2. Canalicular
3. Terminal Sac
4. Alveolar
Term

Which stage of development (1st, 2nd, 3rd , 4th) is the pseudoglandular stage?

What occurs during this stage?

Definition
The pseudoglandular stage is the 1st stage of lung development.

Tubular branching to terminal sac level

this occurs late in the embryonic period of development.
Term

Which stage of development (1st, 2nd, 3rd , 4th) is the canalicular stage?

What occurs during this stage?

Definition
The canalicular stage is the 2nd stage of lung development.

It involves the lung tissue becoming highly vascularised, the presentation of some terminal sacs.

It occurs early in the foetal period of development
Term

Which stage of development (1st, 2nd, 3rd , 4th) is the terminal sac stage?

What occurs during this stage?

Definition
The terminal sac stage is the 3rd stage of lung development.

The terminal sac formation continues and the lining of the sac thins.
Type 1 & 2 cells differentiate and surg=factant is produced.
Term

Which stage of development (1st, 2nd, 3rd , 4th) is the alveolar stage?

What occurs during this stage?

Definition
The alveolar is the 4th stage of lung development.

It involves the commencement of alveoli formation, with capillaries bulging into the lumen.
Surfactant production increases to a level sufficient to sustain life.
This stage occurs late in the foetal period & continues after birth.
Term
What makes up the respiratory fluid & where does it come from?
Definition
-Respiratory tract glandular secretions
- Amniotic fluid - although most kept out by the larynx.
Term
What respiratory changes occur at birth?
Definition
- Rapid decrease inO2, increase in CO2 stimulates breathing
- Bronchial tree & alveoli expand - this is maintained by surfactant.
- Lung expansion -> pulmonary vasodilation -> decreased resistance b=to blood flow within the lungs.
- Ductus arteriosus constricts.
Term
How is fluid removed from the lungs at birth?
Definition
- Flows out into pharynx & mouth
- Evapouration into respired air
- Absorption into pulmonary lymphatics
Term
What do the pleuropericardial membranes originate from?
Definition
Folds of somatic mesoderm on the lateral body walls
Term
How is the pericardial sac formed?
Definition
by an ongoing expansion of the ventral margin of the lungs -> the pleuropericardial membranes divide the IEC between the pericardial cavity and pleural cavity to form the pericardial sac.
Term
What structures is the primitive diaphragm derived from?
Definition
- Septum transversum
- Pleuroperitoneal membranes
- Dorsal mesentry
- Somitic cells from caudal cervical somites.
Term
What structures is the definitive diaphragm dervived from?
Definition
- Muscular component - pleuroperitoneal folds, body wall
- Tendinous component - Spetum Transversum
Term
In the formation of the simple gut, what structure is the lumen derived from?
Definition
The cavity of the yolk sac - part of this cavity is incorportated into teh folding of teh embryonic disc as it folds.
Term
What cells are the layers of the simple gut tube made up of?
Definition
Epithelial lining = endoderm
The remainder of the wall = splanchnic mesoderm
Term
How is the simple gut tube attached early in development?
Definition
- Dorsal mesentry - persists as mesentries in adult\
- Ventral mesentry - mostly degenerates. some remnants remain.
Term
Which structures in the adult animal are derived from the early gut tube attachment - the ventral mesentry?
Definition
1. Lesser omentum
2. Falciform ligament
3. Median ligament of bladder
Term
Which structures are dervived from the embryonic foregut?
Definition
1. Pharynx & related structures
2. LRT
3. Oesophagus
4. Stomach
5. Proximal duodenum
6. Liver & biliary system
7. Pancreas
Term
Which structures are dervived from the embryonic midgut?
Definition
1. distal duodenum
2. Jejunum
3. Ileum
4. caecum
5. Proximal colon
Term
Which structures are dervived from the embryonic hindgut?
Definition
1. Distal colon
2. rectum
3. anal canal
4. Urinary bladder
5. Urachus (not in adult)
6. Most of urethra
Term
How does the stomach first appear as it starts to develop?
Definition
- Dilation of gut tube, cranial to the septum transversum.
- It moves caudally as the lungs expand and oesophagus elongates.
- The greater curvature is positioned dorsally
Term
During the embryonic period the stomach rotates - which direction?
Definition
- The stomach rotates ~90 degrees around its longitudinal axis.
- The greater curvature rotates towards the left side.
- During this period the ruminant stomach compartments form.
Term
During the foetal period the stomach rotates - which direction?
Definition
The stomach makes its second rotation ~90degrees around a dorsoventral axis through the body.
The distal end of the stomach is carried from CD to right side of body and cranially.

(counter-clockwise when viewed from dorsally.
Term
How does the hepatic diverticulum form?
Definition
It grows out from the foregut into the ventral mesentry, toward the septum transversum
Term
What diverticula form from the hepatic diverticulum?
Definition
1. Ventral pancreatic diverticulum
2. Cystic diverticulum -> gall bladder
Term
What is the origin of the dorsal pancreatic diverticulum?
Definition
It grows out from the foregut into the dorsal mesentry
Term
What cells is the primordial liver (hepatic diverticulum) composed of and what does it eventually form?
Definition
- Endoderm - hepatocytes, bile canaliculi, hepatic ducts
- Splanchnic mesoderm - CT framework of liver
Term
How does the hepatic diverticulum expand? Which blood vessels does this involve?
Definition
It engulfs the vitelline and then the umbilical veins. This forms the hepatic sinusoids.
The ductus venosus within the liver links the umbilical vein with the caudal vena cava
Term
What is the relationship between the primordial liver and the septum transversum?
Definition
Primordial liver expands through ventral mesentry & contacts septum transversum
Liver surface remains adherent to diaphragm in adult
Term
Why does the foetus have a large liver?
Definition
It contains haemopoietic cell clusters, resonsible for RBC production.
Term
How is the pancreas formed?
Definition
From 2 diverticula - ventral and dorsal.
the 2 diverticula fuse to create the pancreatic body & lobes. This occurs as the gut wall expands.
Term
What remnants of the pancreastic formation are obvious in the adult horse & dog?
Definition
There are 2 pancreatic ducts, one from each of the primordial diverticula.
However, one regresses in pig, ruminants and cats.
Term
How do gut loops begin to form in the midgut?
Definition
A U-shaped loop created when gut elongates faster than the body length.
This loop has a cranial & caudal limb.
The cranial mesenteric a. courses through the centre of the loop.
Term
How is the root of the mesentry formed?
Definition
Associated with disproportionate elongation of limbs of the U-shaped mid-gut loop.
The limbs rotae around the primordium of the cr mesenteric a.
Term
What is the physiological herniation of the midgut?
Definition
The elongating midgut moves into the umbilical cord late in embryonic period, before returning to abdominal cavity.
Term
What is the urogenital septum?
Definition
It is has a horizontal fold cranially and lateral ridges caudally.
These act to separate the anal and urogenital sinuses
Term
Describe the histiogenesis of the intestinal wall
Definition
Temporary occlusionof gut lumen

Proliferation of endodermalcells→ occlusion

Occurs toward end of embryonic period of development

Vacuoles form shortly thereafter & fuse → recanalisation

Villiformation & cellular differentiation

Functional maturation of cell types
Term
Define the term Zygote
Definition
The conceptus immediately after fertilization. A very large single cell.
Term
What are totipotent cells?
Definition
Cells of the blastomere up to the 8-cell stage. Capable of becoming any cell in the body
Term
Where does cleavage of the zygote occur?
Definition
Within the uterine tube, in the isthmus.
Term
Define the term Morula
Definition
A morula is a conceptus up to the 16-64 cell stage
Term
Define the term Blastocyst
Definition
The blastocyst is the morula once the blastocyst cavity forms (filled with fluid)
Term
What are the trophoblast cells?
Definition
single layer of cells on the periphery of the blastula.
Term
What is the role of the trophoblast cells?
Definition
- Trophoblast cells are involved in absorption of nutrients from the uterus.
Later on they participate in formation of extra-embryonic membranes.
Term
What is the role of the zona pellucida surrounding the blastocyst?
Definition
Prevents adhesion of trophoblast cells to the endometrial lining.
Term
How does the bilaminar embryonic disc start to form?
Definition
The cells from the inner cell mass delineate -> form a layer lining the inside of the ICM & trophoblast = hypoblast.
Term
What does the hypoblast give rise to?
Definition
The endoderm
Term
Describe the epiblast
Definition
Outer layer of cells on the bilaminar disc. They are continuous with the trophoblast layer of the edge of the disc.
Term
What are the three layers of the trilaminar embryonic disc?
Definition
1. Ectoderm
2. Mesoderm
3. Endoderm
Term
Which structures arise from ectoderm?
Definition
1. Epidermis of skin
2. Nervous system
Term
Which structures arise from endoderm?
Definition
Epithelial lining of:
1. GIT
2. LRT
3. Bladder
4. Urethra
Term
Which structures arise from mesoderm?
Definition
1. Bone & Muscle
2. CV system
3. Urogenital system
4. Serous membranes
Term
What is the primitive streak?
Definition
An accumulation of epiblast cells forming 2 parallel ridges & a depression between them.
It is the centre of cellular proliferation
Term
What occurs during gastrulation?
Definition
- Epiblast cells proliferate & form primitive streak.
- These cells then migrate into the:
1. Hypoblast layer -> "intraembryonic endoderm"
2. space btw the epiblast & hypoblast layers of
embryonic disc -> Intraembryonic mesoderm
- Mesodermal cells btw epiblast & hpoblast proliferate & migrate to create middle layer of cells btw trophoblast & hypoblast layers -> extraembryonic mesoderm
- Mesoderm splits into:
1. Somatic mesoderm
2. Splanchnic mesoderm
Term
What is somatopleure?
Definition
Somatic mesoderm layer + ectoderm
Term
What is splanchnopleure?
Definition
Splanchnic mesoderm layer + endoderm
Term
What is the septum transversum?
Definition
A thickened area of mesoderm at the cranial margin of the embryonic disc. Will become the diaphragm.
Term
Where does the vascular network first begin to form?
Definition
As cellular cords within the splanchnic mesoderm of embryonic disc & yolk sac
Term
How is the single heart tube formed?
Definition

- Paired heart tubes form in splanchnic mesoderm craniolateral to oropharyngeal membrane.

- These fuse to create single heart tube, caudal to the stomadeum

- This creates a cardiac bulge.

- Themesoderm of heart tube then differentiates :

1. Inner lining - endothelial cells.

2. Outer layer - epimyocardial mantle secretes thick cardiac jelly, separates mantle from inner lining.

Term

What are the vitelline vessels and how are they formed?

 

Definition
The vitelline vessels are vessels within the yolk sac that develop from a vascular network in the wall of the yolk sac that fuses with the intra-embryonic vascular network.
Term
What are the components of the heart tube in the embryo?
Definition
From venous to arterial end:
1. sinus venosus - right and left horns
2. Atrium
3. Ventricle
4. Bulbous cordis - tapers towards arterial end
5. Truncus arteriosus
Term
What occurs during bending of the heart tube?
Definition
- A U-shape then S-shape is formed -> alignment of primordial heart chambers
Term
What occurs during division of the artioventricular canal?
Definition
- The endocardial cushions expand from the opposing walls of the opening and fuse.
- Primordia of the R & L AV openings are formed.
Term
What is the structure & function of the septum primum?
Definition
The septum primum is a thin, cresent-shaped fold that expands from the dorsal atrial wall toward the endocardial cushions. This is part of the partitioning of the atrium.
Term
What is the foramen primum?
Definition
The foramen primum is a gap in the septum primum between the free edge of the septum primum fold and the endocardial cushions.
This foramen disappears when the fold fuses with the cushions.
Term
What is the foramen sceundum?
Definition
The foramen secundum is a spherical opening that forms in the septum primum before the foramen primum is obliterated.
Term
What is the septum secundum?
Definition
The septum secundum is a thick cresent shaped fold that forms parralell and to the right of the septum primum.
Term
What is the foramen ovale?
Definition
The foramen ovale is a gap between the free edge of the septum secundum and the opposing atrial wall.
It persists throughout gestation.
This opening is slightly covered by the septum primum, which acts as a valve, permitting unidirectional blood flow from R -> L atrium only.
Term
What is the fate of the sinus venosus?
Definition
The sinus venosus gets re-aligned with the enlarging R atrium.
Increased venous inflow via R horn of sinus venosus & decreased via left horn.
The right horn of the SV is incorporated into the sinus venarum of R atrial wall near vena caval openings.
The left horn of the SV is incorporated into the terminal section of the coronary sinus as it enters the R atrium
Term
How does the pulmonary vein become incorporated into the left atrium?
Definition
The pulmonary vein grows as a single vessel outward from the left atrium as the lungs form.
The vessel branches distally towards the lung lobes.
Re modelling of the L atrium occurs & the pulmonary vein is incorporated into the L atrium as it expands.
Term
What does the primitive ventricle become?
Definition
The definitive Left ventricle
Term
What primordial structure does the definitive Right ventricle arise from?
Definition
The bulbous cordis
Term
How is the ventricle partitioned?
Definition
The interventricular spetum, a thick ridge, forms at the junction between the single ventricle and the bulbous cordis.
This ridge extends toward the fused endocardial cushions but does not contact them.
The gap between ridge & cushions is closed when the outflow tract of heart is divided by the conotruncal ridges.
Term
What occurs during partitioning of the outflow tract?
Definition
The outflow tract (bulbous cordis and truncus arteriosus) is divided by spiral ridges.
These ridges form from opposing walls of the outflow tract, then expand and fuse.
This fushion creates the aorticopulmonary septum.
Term
How does the aorticopulmonary septum effect blood flow from the heart?
Definition
The aorticopulmonary septum divides the outflow tract so that blood will flow from the L ventricle into the aorta and blood from the R ventricle will go via the pulmonary trunk.
Term
What is the aortic sac?
Definition
The aortic sac is a bulge at the distal end ot the outflow tract of teh heart. The aortic arches arise from here.
Term
What are the dorsal aortae?
Definition
They are paires (R & L) longitudinal vessels formed in splanchnic mesoderm of the embryonic disc.
They fuse caudal to the forelimb buds to form 1 aorta.
Term
How are the heart valves formed?
Definition
The aortic & pulmonayr valves form as small outgrowths from the conotruncal ridges and the walls of the proximal truncus arteriosus.
The AV valves develop from the ventricular myocardium surrounding the AV canals.
Term
Where do the aortic arches arise from?
Definition
The ventral aortae extend cranially from the truncus arteriosus which is where the aortic arches arise, extending to the dorsal aortae.
Term
How many aortic arches are there?
Definition
There are five pairs of vessles making up the aortic arches.
Arches are numbered 1st, 2nd, 3rd, 4th, 6th.
Term
What is the surface feature corresponding to each od the aortic arches?
Definition
The brachial arches.
Term

What sequence do the aortic arches arise and also degenerate (or develop) in?
Definition
Craniocaudal
Term
What is the fate of the 1st and 2nd aortic arches?
Definition
The first and second arotic arches regress as the 3rd & 4th arches arise. May contribute to some minor vessels in the head.
Term
What is the fate of the 3rd aortic arches?
Definition
The 3rd aortic arches become the common & internal carotid arteries.
Buds from these arches to form the external carotid arteries.
Term
What is the fate of the 4th aortic arches?
Definition
The Left 4th aortic arch become the definitive aortic arch.
The right 4th aortic arch contributes to the R subclavian artery.
Term

 

What is the fate of the 6th aortic arches?

Definition
Buds from the 6th aortic arches become the pulmonary arteries.
Proximally the aortic arche scontribute to the pulomary trunk.
Distally - the left arch forms the ductus arteriosus, while the right arch regresses.
Term
What is the function of the ductus arteriosus?
Definition
To shunt blood from the pulmonary trunk to the aorta, so that it by-passes the lungs.
Term
Where do the vitelline arteries arise form?
Definition
The aorta at teh level of teh midgut.
Term
Where do the umbilical arteries arise from?
Definition
The caudal end of teh aorta.
Term
Which vessels are derivatives of the vitelline arteries?
Definition
1. Coeliac artery
2. Cranial mesenteric artery
3. Caudal mesenteric artery
Term
What is the function of the vitelline arteries in the embryo?
Definition
The vitelline arteries recieve blood from the dorsal aorta and supply the yolk sac and therefore also supply the primitive gut with blood.
Term
What is the function of the umbilial arteries in the embryo?
Definition
The umbilical arteries recieve blood from the aorta and terminally brnch as the allantoic arteries.
Term
How is venous blood returned to the heart in an embryo?
Definition
Via :
1. Paired cardinal veins - From cranial & caudla cardinal veins into the sinus venosus of the heart.
2. Paired vitelline veins - from yolk sac to sinus venossu of heart.
Term
What is the primordial structure that gives rise to the cranial vena cava?
Definition
The Right cranial cardinal vein.
Term
What is the fate of the vitelline veins?
Definition
-Incorporated into the expanding liver as the hepatic sinusoids.
- Caudal to the developing liver they form an anastamoses around the gut loops - Some parts regress while the remainder becomes the hepatic portal vein.
- Cranial to the developing liver - The L vein degenerates, the R vitelline vein forms the caudal vena cava.
Term
Which structure gives rise to the caudal vena cava?
Definition
The Right vitelline vein, cranial to the developing liver.
Term
What is the function of the umbilical veins in the embryo?
Definition
They convey blood from the allantoic veins to the sinus venoss of the heart.
Term
What is the fate of the umbilical veins?
Definition
- Incorporated into the expanding liver as the hepatic sinusoids (like the vitelline veins)
- Cranial to the dveeloping liver they regress.
- Caudal to the developing liver:
- R vein degenerates
- L vein enlarges - suuplies blood to ductus venosus in
liver, some blood enters liver parenchyma.
Term
What is the ductus venosus and what is it's function?
Definition
The ductus venosus is a channel through the liver that links the L umbilical vein to the caudal vena cava (R vitelline vein)
This means most of the oxygenated blood returing from the placenta by-passes the hepatic sinusoids.
Term
When does the ductus venosus degenerate in each of the domestic species?
Definition
- Pig & horse - DV degenerates during foetal period of development.
- Ruminants and carnivores - degenerates at parturition.
Term
Which structure in the neonate is a reminant of the umbilical vein?
Definition
The round ligament of the bladder.
Term
Which structure in the neonate is a reminant of the ductus venosus?
Definition
The ligamentum venosum within the liver.
Term
Where do Neural crest cells originate from?
Definition
The neural folds - they migrate to then contribute to the mesenchyme of head & neck, including skull, meninges, sclera, choroid & structures of the branchial arches.
Term

Mesenchymal cells arise from one of two origins, what are these?

 

Definition
1. Mesoderm
2. Neurectoderm
Term
How does the musculature of teh head & neck form?
Definition
Cells of the somitomeres & cranial somites migrate into the developing head/neck (influenced by the neural crest cells) and then multiply & differentiate into skeletal muscle fibres.
Term
Which embryonic structure give rise to the meninges?
Definition
The neural crest cells surrounding the brain.
Term

What are the three flexures that appear in the developing brain?

What order do they appear in?

Definition
In order of appearance:
1. Midbrain flexure
2. Cervical flexure (at junction of SC & mylencephalon)
3. Pontine flexure.
Term

What is the stomadeum? How is it formed?

 

Definition
A depression on the surface of the embryo, formed with the head folding of the embryonic disc.
The 1st branchial arches form the lateral wall of the stomadeum.
Term
Where are the branchial arches located?
Definition
Visible as transverse ridges ventrolaterally in the head/neck region.
Term
What are other names for the Visceral arches?
Definition
- Branchial arches
- Pharyngeal arches.
Term
How many branchial arches develop in the embryo? How many are visible externally?
Definition
The 1st, 2nd, 3rd, 4th and 6th branchial arches but only 1st-4th visible externally.
Term
Which structures mark the separation between branchial arches both internally and externally?
Definition
Internally - Pharyngeal pouches
Externally - Branchial grooves
Term
Which structures are contained within each branchial arch?
Definition
- An aortic arch artery (1st, 2nd, 3rd, 4th or 6th)
- A cranial nerve (5th, 7th, 9th, 10th)
Term
Which structures are derived from the 1st branchial arch?
Definition
- Jaws
- Muscles of mastication
- Pinna & auditory ossicle - some contribution
Term
Which nerve supplies the 1st branchial arch?
Definition
Cranial nerve V
Term
Which structures are derived from the 2nd branchial arch?
Definition
- Most of the hyoid apparatus
- Part of the pinna
- Part of auditory ossicles
- All of the muscles of facial expression
Term
Which nerve supplies the 2nd branchial arch?
Definition
Cranial nerve VII
Term

Which structures are derived from the 3rd branchial arch?

 

Definition
- Part of hyoid apparatus
- Some pharyngeal muscles
- Some cartilages of larynx
Term
Which nerve supplies the 3rd branchial arch?
Definition
Cranial Nerve IX
Term
Which structures are derived from the 4th & 6th branchial arches?
Definition
- Remainder of pharyngeal muscles & larynx, including intrinsic musculature.
Term
Which branchial arches are suppplied by Cranial Nerve X?
Definition
4th & 6th
Term
Which embryonic structure is the external ear canal derived from?
Definition
The 1st branchial groove.
Term
What is the fate of the 2nd & 3rd branchial grooves?
Definition
They disappear when the 2nd branchial arch expands caudally & fuses with the surface of the ectoderm.
Term
What are the branchial membranes?
Definition
Thin tissue layers dividing the branchial grooves ffrom the pharyngeal pouches.
Term
Which structure gives rise to the tympanic membrane?
Definition
The 1st branchial membrane. This is the only branchial membrane that persists as a permanent structure.
Term
Which structure gives rise to the middle ear cavity and the auditory tube?
Definition
The 1st pahryngeal pouch
Term
What structures do the 3rd & 4th pharyngeal pouches give rise to?
Definition
- Parathyroid glands
- Calcitonin-producing cells of the thyroid gland
- Thymus (excluding lymphocytes)
Term
How is the definitive tongue formed?
Definition
- Derived from several swellings that arise from the floor of the caudal stomadeum & floor of pharynx.
- It is associated with the 1st-4th branchial arches.
- Sensory innervation from 5th, 7th, 9th & 10th cranial nerves
- Musculature derived from migrating somitic cells.
Term
How is the nose formed?
Definition
- Nasal placodes (circular thickenings of endoderm, surrounded by swelling of mesenchymal tissue = nasal processes.
- A nasal pit forms in the centre of each nasal process.
- Nasal processes fuse medially -> upper lip & primary palate.
- Maxillary processes expand & fuse with nasal processes.
Term
What structure is the primary palate formed from?
Definition
- The primary palate is derived from fusion of the medial portions of the nasal processes.
Term
Which structure is the secondary palate derived from?
Definition
The secondary palate is derived from internal folds extending medially from maxillary processes of 1st branchial arch.
Term
Which structures are the pinna of the ear derived from?
Definition
The mesenchymal proliferation in the 1st and 2nd branchial arches.
Term
Which structures are the auditory ossicles derived from?
Definition
The mesenchyme of 1st & 2nd branchial arches.
Term
How is the inner ear formed?
Definition
The inner ear is formed from the otic placode -> a depression from teh outer surface forming the otic vesicle -> membranous labyrinth of the ear.
Term

How is the retina of the eye formed?
Definition
The retina is derived from an outpocketing of the forebrain vesicle that extends towards the surface ectoderm = the optic cup.
Term
Which embryonic tissue is the lens of the eye derived from?
Definition
The lens is formed from the lens vesicle -> derived from a thickening of ectoderm that becomes depressed from the surface.
Term
How are the sclera and choroid of the eye formed?
Definition
The sclera & choroid are derived from condensation of mesenchyme derived from neural crest cells.
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