Shared Flashcard Set

Details

zCombination Chemotherapy
Biochemical and Molecular Principles of Drug Action Biochemical and Molecular Principles of Drug Action
44
Pharmacology
Professional
03/13/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Methotrexate
Definition
S Phase
Folate-> Tetrahyrofolic Acid
Renal Toxicity
Immunosupressive
Term
Flurouracil
Definition
Term
Mecaptopurine
Definition
Purine precursor -> IMP
IMP -> Ribonucleotides
Term
Hydroxyurea
Definition
S Phase
Ribonucleases -> Deoxyribonucleases
Nucleotides _ DNA
Cytosine -> Nucleotides
Term
Thioguanine
Definition
Purine precursor -> IMP
IMP -> Ribonucleotides
Term
Alkylating agents
Definition
G0 Phase
Term
Antibiotics
Definition
DNA -> RNA
Term
Mitotic Disruptors
Definition
Term
Cyclophosphamide
Definition
Alkylating agents
Term
Doxorubicin, Bleomycin
Definition
Antibiotics
Pulmonary Toxcity
Term
DNA syn block analogues
Definition
Antimetabolites
Term
platinum complexes (Cisplatin)
Definition
Term
procarbazine
Definition
leukemia and pulmonary toxicity
Term
plant alkaloids (Taxol)
Definition
Term
HYdroxyurea
Definition
targets ribonucleotide reductase and prevents the conversation of nucleotide to deoynucleotides, and DNA synthesis
Term
Cisplatin
Definition
targets guanine residues and causes intra-strand DNA crosslinks

G0 Phase
Term
Etoposide
Definition
targets topoisomerase II and stabilizes double-stranded DNA beaks
Term
Bleomycin
Definition
binds DNA and chelates iron to cause free radical-induced DNA strand breaks.

G2 Phase
Term
Cisplatin and bleomycin damage DNA, while etoposide (VP-16) inhibits DNA repair. (T/F)
Definition
T
Term
How does signaling through the EGFR promote cell growth
and survival?
Definition
Intracellular signals promote activation of genes involved cell proliferation.
Term
Elotinib (TKI) targets EGF to block cancer cell growth T/F
Definition
F

Tyrosine Kinase Inhibitors can only bind to tyrosine kinase receptor
Mab can bind both receptor and ligand
Term
Vinblastine
Definition
M Phase
Term
Vincristine
Definition
M Phase
Term
Pacilitaxel
Definition
M Phase
Term
5-flurouracil
Definition
Thymine->nucleotide
Term
Alkylating agents
Definition
Cisplatin
iomustine
procarbazine
Term
Topoisomerase inhibitors
Definition
Doxorubicin
etoposide
Term
Antimetabolites
Definition
Gemcitabine
Methotrexate
Term
Tubulin binders
Definition
vinblastine
Vincristine
paclitaxel
Term
Molecularly targeted
Definition
erlotinib
imatinib
sorafenib
sunitinib
tretinoin
herceptin
Term
Miscellaneous
Definition
Bleomycin
hydroxyurea
predisone
Term
Herceptin
Definition
Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, binds to the extracellular domain of the HER2 protein, which is overexpressed in 25 to 30% of primary breast cancers. By binding to the HER2 protein, trastuzumab inhibits the growth of tumor cells and mediates antibody-dependent cellular cytotoxicity (ADCC) in cancer cells that overexpress the HER2 protein
Term
Cetuximab, Trastuzumab
Definition
EGFR inhibitor
Term
Gefininib, Erlotinib
Definition
Inhibits Tyrosine Kinase
Term
Farnesyltransferase inhibitors
Definition
Blocks RAS activation
Term
Sorafenib
Definition
Inhibits RAF
Term
MEK inhibitors
Definition
duh
Term
3 advantages of combination therapy
Definition
1. Suppression of drug resistance - less chance of a cell developing resistance to 2 drugs than to 1 drug.
2. Increased cancer cell kill - administration of drugs with different mechanisms of action.
3. Reduced injury to normal cells - by using a combination of drugs that do not have overlapping toxicities, we can achieve a greater anticancer effect than we could by using any one agent alone.
Term
ABVD
Definition
Adriamycin, bleomycin, vinblastine, dacarbazine
Term
MOPP
Definition
mustard, vincristine (Oncovin), procarbazine, prednisone
Term
Erlotinib
Definition
EGFR
Term
Sorafenib
Definition
Multi-RTK
Term
Dasatinib
Definition
Bcr-Abl
(Gleevac-R
Term
Crizotinib
Definition
c-MET
Supporting users have an ad free experience!