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Week 12
Pain Mgmt
19
Psychology
Graduate
11/20/2013

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Term
Nociceptors
Definition
sensory neurons that respond to noxious stimuli
Term
Neuropathic Pain
Definition
caused by disease or damage to somatosensory neurons;
peripheral or central;
ex: spinal cord injury, MS, diabetes, virus, cancer
Term
Fibromyalgia
Definition
Widespread pain;
More common in women;
Allodynia – painful responses to normal pressure; Additional dysfunctions:
- Fatigue
- Joint stiffness
- Sleep disturbances
Co-morbid w/ depression & anxiety;
Causes unknown;
Pharmacotherapy = FDA approval for pregabalin & duloxetine
Term
Opioid Pain Meds
Definition
Morphine;
Levorphanol;
Methadone;
Hydromorphone;
Hydrocordone;
Oxycodone;
Tramadol;
Fentanyl
Term
Sites of Action for Tramadol
Definition
u-opioid receptor antagonist;
NET;
5HT2C;
TRPV1
Term
Cyclooxygenase (COX)
Definition
-NSAIDS act by inhibiting COX enzymes (1 & 2)
Term
NSAIDs
Definition
- non-selective COX inhibitors (aspirin, ibuprofen, naproxen)
- selective COX-2 (Celebrex, Vioxx, Bextra)
Term
Celecoxib
Definition
NSAID;
Celebrex;
probably no advantage over ibuprofen or acetaminophen
Term
Rofecoxib
Definition
NSAID;
Vioxx;
withdrawn in 2004 (increased risk of heart attack/stroke)
Term
Valdecoxib
Definition
NSAID;
Bextra;
withdrawn in 2005 (increased risk of heart attack/stroke)
Term
Aspirin
Definition
acetylsalicylic acid;
irreversible inhibitor of COX
Term
Reye's Syndrome
Definition
potentially fatal disease;
rash, vomiting, liver damage, encephalopathy;
mostly children - rare in adults;
cause unknown, but associated w/ aspirin use
Term
Acetaminophen
Definition
not a NSAID;
not associated w/ Reye's Syndrome
Term
Reversible COX Inhibitors
Definition
ibuprofen (Advil, Motrin);
Naproxen (Aleve, Naprosyn)
Term
Ibuprofen
Definition
NSAID;
reversible COX inhibitor
Term
Naproxen
Definition
NSAID;
reversible COX inhibitor
Term
Hydrocodone
Definition
derived from codeine;
sold in combo w/ acetaminophen or NSAID
Term
Oxycodone
Definition
Oxycontin = long-acting formula;
Perodan = oxycodone/aspirin;
Percoset = oxycodone/acetaminophen
Term
Other Pain Trmts
Definition
- Tramadol;
- Fentanyl;
- Pregabalin & Gabapentin
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