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viral hep
viral hep and treatment
29
Pharmacology
Graduate
09/09/2012

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Term
Hep B coninfections with
Definition
Hep D
Term
Hep A
Definition
infectious hep- acute viral
fecal-oral route
vaccine
self-limiting
Term
high risk populations for Hep A
Definition
kids
close contact
MSM
travelers
preggers
IDUs
work w/primates
Term
Hep A symptom phase
Definition
incubation-asymptomatic
preicteric-no appetite, n/v, fever
icteric-jaundice, incr bilirubin, dark urine, light stool
Term
Hep A vaccines
Definition
Havrix
Vaqta
Twinrix- Hep A & B. not for kids.
Term
Hep A vaccine schedule
Definition
0 months
6 month booster
Term
pts for Immunoglobulin
Definition
give to <12months old
post expose prophy for >40 yrs old
allergic to Hep A vaccine
chronic liver disease
Term
Immunoglobulin
Definition
passive immunity
give during incubation period
interact with live vaccines -MMR and Varicella
Term
Hep B
Definition
most serious Hep
blood born
causes chronic liver disease and can lead to cirrhosis and liver cancer
Term
Hep B
Definition
most serious Hep
blood born
causes chronic liver disease and can lead to cirrhosis and liver cancer
Term
Hep B s/s/
Definition
anxiety, malaise
ascites, variceal bleeds, jaundice
hepatic encephalopathy
vomiting, seizure
Term
Hep B vaccine
Definition
inactivates
Recombivax HB
Engerix-B
Twinrix- Hep B & A
Comvax- dTAP, Hep B, HIB- peds
Pediarix-dTap,HepB, polio
Hbig-hyper Hep B, Nabi-HB- post exposure prophy or prevent after liver tx
Term
Hep B vaccine schedule- single antigen
Definition
1mL at 0, 1,6 months
1st dose within 24 hours of birth
Term
Hep B drugs
Definition
Interferon (IFN-alpha2b)
lamivudine
telbivudine
adefovir
entecaviir
pegylated IFN-alpha2a
tenofovir
Term
pegasys-brand
Definition
peginterferin alpha2a

Hep B tx
combo more effective
Term
epivir-HBV- brand
Definition
lamivudine

Hep B tx
nucleoside reverse transciptase inhibitor (NRTI)
Term
hepsera-brand
Definition
adefovir
NRTI

Hep B tx
1 yr tx
combo w/lamivudine
nephrotixicity possible
Term
baraclude-brand
Definition
entecavir

NRTI

Hep B tx
tx-1yr or lifelong if decompensated liver disease
next after lamivudine fail
Term
tyzeka-brand
Definition
telbivudine

Hap B tx
NRTI
tx-1 yr
documented resistance
Term
viread- brand
Definition
tenofovir

NRTI
Hep B tx
1st line tx
less resistance than others
tx 1 yr or life long.
Term
Hep B alt drugs
Definition
Emtricitabine- indicated in HIV tx
combo therapy for pts w/antiviral resistant HBV
Term
Hep C
Definition
most common bloodborne pathogen
ssRNA virus
acute infection leads to chronic in most cases
progression to chronic over 20-30yrs
Term
Hep C acute
Definition
asymptomatic
Term
which hep has no vaccine
Definition
hep C
Term
hep C high risk populations
Definition
IDUs (current/past)
HIV infection
blood/organ transplant b4 1992
receive clotting factors b4 1987
hemodialysis
unexplained high ALT levels, liver dx
healthcare workers post needle stick
child born to Hep C mother
sex partners of Hep C pts
Term
Hep C drugs
Definition
Interferons
Ribavirin
Boceprevir(victrelis)
Telaprevir(incivek)
Term
hep c alt drugs
Definition
taribavirin- prodrug of ribavirin
long acting interferons- albuferon
protease inhibitors
polymerase inhibitors
Term
decompensated cirrhosis
Definition
liver transplant
Term
hemodialysis
Definition
contraindicated to ribavirin
and risk factor for hep C
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