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Vesiculobullous disease
Blk 1
17
Pathology
Professional
09/20/2014

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Term
vesicle
Definition
a small blister or sac less than 1 cm in diameter containing liquid; a small circumscribed elevation of the epidermis or mucous membrane containing a serous liquid
Term
bulla
Definition
a large vesicle, usually 2 cm or more in diameter
Term
core virion
Definition
viral component responsible for the infection
Term
tropism
Definition
matching of a virus with a specific cell type
Term
viral latency
Definition
virions remain harmlessly integrated with the genome of the host cell for prolonged periods if the body's immune system attenuates the activity of the virus or if the infection is sufficiently nontoxic that cell death does not occur
Term
Epstein-Barr virus
Definition
linked to infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma and oral hairy leukoplakia
Term
Cytomegalovirus
Definition
associated with salivary gland disease and immunocompromised patient.
Term
HV1
Definition
primary herpes gingivostomatitis, secondary herpes infections
Term
HSV 2
Definition
genital herpes
Term
HHV6
Definition
roseola infantum
Term
HHV8
Definition
Kaposi's sarcoma
Term
Papillomaviruses
Definition
oral papillomas/warts, condyloma acuminatum, focal epithelial hyperplasia, some carcinomas
Term
coxsackie viruses
Definition
herpangina, hand-foot-mouth disease
Term
Ramsay Hunt Syndrome
Definition
herpes zoster involvement of facial and auditory nerves resulting in facial paralysis and vesicles of ipsilateral external ear, tinnitus, deafness and veritgo
Term
corticosteroids
Definition
treatment that is contraindicated for viral infections
Term
immunologic vesciculobullous disease
Definition
pemphigus, mucous membran pemphigoid, bullous pemphigoid
Term
mucous membrane pemphigoid
Definition
chronic blistering, oral and ocular membranes, antigenic target laminin 5 (epilgrin) and a 180-kd protein (BP180)
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