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Unit 6 - Pharmacogenetics
Test 1
14
Nursing
Undergraduate 3
02/04/2014

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Term
What is pharmacogenetics? What is it's goal?
Definition
The study of variability of responses to medications due to genetic variation.
GOAL: To create an individualized drug therapy for best choice and dosage of drug.
Term
What is pharmacogenomics?
Definition
Study of genetic variations associated with drug efficiency.
GOAL: To create drugs that are tailor-made for individuals and their own genetic makeup.
Term
What are the benefits of pharmacogenetics?
Definition
1.) Choosing the right dose for patient
2.) Determines patient's risk for getting a particular disease and designing an effective prevention strategy.
3.) More accurate diagnosing
4.) More accurate prescription
5.) Avoid harmful sideeffects
Term
What is purinethol?
Definition
cancer medication.
Term
Why did some benefit and some die from purinethol before extensive research?
Definition
The body breaks down this drug by the TPMT enzyme. Not everyone has the same amount of this enzyme so not everyone had the ability to metabolize all of the drug. The left over part kills healthy body cells as well as the cancer cells.
Term
What percentage of children can fully break down Purinethol?
Definition
89%
Term
What does SNP profiling determine?
Definition
Genetic variations in different people/populations and their rxn to certain medications/dosages.
Term
Since certain sequences only happen a small percentage of the time, this small percentage will react _________ than the majority.
Definition
Differently
Term
What are the 2 approaches to SNP?
Definition
1.) Genomic
2.) Functional
Term
What is genomic snp profiling view?
Definition
Big picture. Identify and catalog all SNP's in human genome and compare numerous individuals to identify the differences. Require databases for uploading. Available for everyone to see.
Term
What is the functional snp profiling view?
Definition
Interested in a particular disease or drug and the biological processes involved in diseases and drug responses. THey know select genes are known to be involved in these processes/responses so they examine people who have them and people who don't.
Term
What is GINA? What does it state?
Definition
Genetic Information Nondiscrimination Act. Cannot discriminate against anyone based on their genetic information. Falls in line with HIPAA.
Term
Why should you genetic test for a patient who is being prescribed warfarin?
Definition
- Can find their optimal dosage. May need more or less depending on their race.
Term
Why should you genetic test for a patient who is being prescribed plavix?
Definition
Up to 40% of patients are ultra rapid metabolizers so they may need their dose adjusted and lab results looked at more closely.
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