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Unit 11
drugs
40
Chemistry
Undergraduate 4
11/14/2010

Additional Chemistry Flashcards

 


 

Cards

Term

Absorption rate constant

Definition

value describing how much drug is absorbed perunit of time

Term
bioavailability
Definition

the amont of drug in the formulation that the system of the patient can absorb

Term

Biophase

Definition

the site of interaction between the drug molecule and its receptor

Term

C-max

Definition

maximum plasma level of drug

Term

Compartment

Definition

a pharmacokinetic term for the drug concentration, C and the volume of distribution of that drug

Term

First-order kinetics

 

Definition

the rate of change of plasma drug drug concentration that is dependant on  the concentration itself; that is a constant proportion of drug is removed with time

Term
LADME
Definition

acronym fo the time course of drug distribution:liberation, absorption, distribution, metabolism, and elimination

Term

Liberation

Definition

the process of drug release from the dosage form

Term

MEC,MIC

Definition

the minimum effective concentration, or the minimum inhibitory concentration for a drug to be active. Drug is effective at any level above this value

Term
Michaelis-Menten  kinetics
Definition

a method of transforming drug plasma levels into a linear relationship using the parameters of drug concentraions and a constant K(m)

Term
Peak method of dosing
Definition

a method whereby the drug must reach a specified maximum level to be effective

Term

Pharmokinetics

Definition

the "quantitative" study of drug dispostion in the body

Term

Prodrug

Definition

a parent compound that is usually not active and must be mateabolized to the active form

Term

Steady State

Definition

A condition in which drug input and drug output are equal

This is obtained when after multiple dosing, the peak and the trough conventration after eac dose oscillate within a certain range

Term
slow release
Definition

a dosage form of drug that allows the drug to be slowly placed into solution

Term

t max

Definition

the time of maximum drug concentration

Term

Therapeutic window

Definition

a term describing a bellshaped response curve of drug level versus pharmacological response

Term
Trough concentration
Definition

the lowest drug concentration reached, suually before the next dose is given

Term

Zero-order kinetics

Definition

the rate of change of plasma concentration, independent of the plasma concentration, a constant amount is eliminated per unit of time

Term

zero-time blood level

Definition

a hypothetical blood concentration obtained by extrapolation back to the initial or zero, time of administration. Usually this yields a maximal value.

Term

Phenobarbitol

Definition

An antiepilepitc

it reduces excitability of entire nerve cells (sedative) binds to albumin (may have a worry of competitive binding)

Term

phenytoin

Definition

Antiepileptic drug

minimizes epileptic seizures

prolongs synaptic inactivation

Term
Primadone
Definition

Antiepileptic drug

prolongs synaptic inactivation

Term

Carbamazepine

Definition

Antiepileptic drug

 used to treat trigemital myalgia

is a metabolite of phenobarbitol

works to prolong synaptic inactivation

Term
Digoxin
Definition

Caridoactive drug

increases the force and velocity of cardiac contraction thereby decreasing conduction velocity through av node essentially slowing the heart rate

Term
Lidocaine
Definition

Cardioactive drug

prevents ventricular arrythmias (irregular heartbeats)

ie. stabilizes heart rate

Term

Quinidine

Definition

Cardioactive drug

Anti malarial drug used to treat malaria

decreases muscle excitability

Term
Procainamide and N-Acetylprocainamide (NAPA)
Definition

Cardioactive drug

both work together to control cardiac arrythmeas

Term
theophylline (thiobromides)
Definition

Brochodilator drug

CNS stimulants, keeps you awake

 

Relxes bronchial smoothe muscles and blood vessels, stimulates respirations and strengthens cardiac muscle

Term

Caffiene

Definition

Bronchiodilator drug

seen in many teas for centuries serves as a head ache pain releiver

 

relaxes obronchial smoothe muscles and blood vessels, stimulates reperation and strengthens cardiac muscles

Term
Amino glycosides
Definition

Antibiotic drug

inhibits bacterial protein synthesis by disruption of mRNA tsl

Term

drugs ending in ycin

Definition

antibiotics

treat gram negative

inhibits bacterial protein synthesis by disruption of mRNA tsl

Term

Chloramphenicol

Definition

Antibiotic drug

used to treat gram neg bacteria

unkown MOA

Term

Lithium

Definition

Antipsychotic drug

used for manic depressive disorders

MOA not understood

Term

Tricyclics

Amitriptyline- Nortriptyline

Imipramine- Desipramine

Definition

Antidepressants

act by blocking uptake of nor-epinephrine and seratonin by presynaptic nerve endings prolonging time of nerve transport  transmission,

exact methods not understood

variable patient response

Term

Methotrexate

Definition

Antineoplastic drug

used to treat cancers (non specific cytotoxin)

inhibits dna synthesis

Term
Cyclosporine
Definition

Immunosuppressant drug

supppresses graph vs host disease

inhibits proliferation of lymphs, inhibits IL2 which blocks T-cell activation

Term
Tacrolimus (FK-506)
Definition

 Immunosuppressant

inhibtis lymph proliferation

T-cells dont proliferate

Term

Salicylate

Definition

Analgesics

component drug in aspirin

serves as a pain killer

unknow method of action

Term

Acetaminophen

Definition

Analgesic

similar to salicylate, has less side effects

unknow mode of action

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