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UCD SF I
science foundations I
62
Science
Professional
09/15/2010

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Term
Average BSA of Adult
Definition
1.73 m^2
Term
Dose for specific pt=
Definition
(BSA of pt/1.73)(Usual dose)
Term
Keq=
Definition
K1/k2
(K is rate constant)
Term
Thermodynamics
Definition
Study of energetics of a system, how it uses energy, and relative stability of components.
Term
Kinetics
Definition
Study of rate at which a system undergoes change.
Term
Energy of Activation
Definition
Barrier to going from reactants to products
Term
1st law of thermodynamics
Definition
energy of universe is constant
Term
deltaE=
(change in internal energy)
Definition
deltaQ + deltaW
(change in heat + change in work)
Term
deltaQ=
(change in heat)
Definition
deltaH
(Enthalpy)
Term
What is enthalpy?
Definition
Heat content
Term
What is entropy?
Definition
Amount of disorder in a system
Term
what does deltaS stand for?
Definition
change in entropy (S)
Term
What does Cp stand for?
Definition
Heat capacity
Term
deltaS=
Definition
Qrev/T
(T is in Kelvin)
Term
How is heat capacity (Cp) defined?
Definition
Cp=qp/dT
Term
deltaS = Cp ln (?)
Definition
T2/T1
(T in Kelvin)
Term
What does negative entropy indicate?
Definition
More order
Term
What is deltaG?
Definition
Free energy
Term
deltaG=
Definition
deltaH-(T)(deltaS)
Term
What is deltaG at equilibrium
Definition
zero
Term
What does negative deltaG mean?
Definition
Reaction proceeds forward
Term
what does negative deltaH indicate
Definition
Heat given off
Term
What is (a) in
deltaG=nRT ln(a2/a1)
Definition
solute activity
Term
What is (c) in
deltaG=nRT ln(c2/c1)
Definition
concentration of solute
Term
What is chemical potential?
Definition
The free energy per mole of substance
Term
in a zero order reaction what does k equal
Definition
-deltaC/delta(time)
Term
What does having a zero order mean?
Definition
the reaction rate is independent of concentration. (rate change constant)
Term
What does having 1st order kinetics mean?
Definition
rate of reaction is dependent on concentration. (rate changes with concentration)
Term
What is meant by second order kinetics?
Definition
rate of reaction involves collision of 2 molecules
Term
second order kinetics equation
Definition
kt=(Co - C)/CoC
Term
First order reaction rate law
Definition
-deltaC/delta(time)=kc
Term
zero order reaction rate law
Definition
-deltaC/delta(time)=k
Term
What order reaction are suspensions?
Definition
zero order
Term
what is definition of shelf life?
Definition
time until drug decomposes to 90% of label claim
Term
What influences reaction rates?
Definition
solvent
ionic strength
dielectric constant
pH
light
temperature
Term
Advantage of using Arrhenius relationship
Definition
can be tested at higher temp.
Term
What does the term t0.9 mean?
Definition
Shelf life
Term
what does X(double dagger) represent
Definition
transition state
Term
What order is the decomposition of the transition state?
Definition
first order
Term
Are catalyst consumed in reactions?
Definition
no
Term
a catalyst ________ the rate reaction, and the equilibrium constant (K) ________?
Definition
increases, remains same
Term
Hydronium ions act as an acid in _____?
Definition
specific acid catalysis
Term
Hydroxide ions act as a base in _____?
Definition
specific base catalysis
Term
what is unit of second order reaction?
Definition
1/(m*s)
Term
what is the unit of first order reaction?
Definition
1/s
Term
Nucleophilic catalysis involves?
Definition
lone pairs of electons stabilizing transition state.
Term
equation for complexion
Definition
Keq=[A-B]/([A][B])
Term
what is Keq also known as
Definition
stability constant
Term
Units for complexion?
Definition
1/molar
Term
complexion is ?
Definition
molecular interaction producing a substance with properties different then reactants
Term
interactions of complexion can be through?
Definition
Electrostatics
Dative covalent bonding
dipolar interactions
hydrogen bonding
Term
How can complexion affect drug performance?
Definition
Increase solubility
decrease solubility
alter drug uptake
change rate of dissolution
targeted delivery
Term
Types of complexes
Definition
metal
inclusion
physical adsorption
Protein-Drug
Term
Primary routs of chemical inactivation
Definition
hydrolysis
Term
Functional group most prone to hydrolysis?
Definition
esters
Term
Which carbon is attacked in hydrolysis?
Definition
Acyl Carbon (>C=O)
Term
What is oxidation?
Definition
conversion of one oxidation state to a higher oxidation state by removing electrons. (Loss of Electrons=Oxidation) LEO
Term
What is mechanism used during respiration and oxidative phosphorylation in animals?
Definition
Oxidation
Term
Three steps in free radical oxidation
Definition
initiation
propagation
termination
Term
energy of photon is:
Definition
E=hv
(h= 6.625 X 10^-27 v is freq in Hz)
Term
What can happen to molecule in excited state?
Definition
Chemical reaction
energy transfer
Heat dissipation
Emission
Term
first order kinetic reaction slope equals?
Definition
-k/2.303
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