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Toxicology Test 2
Actual Material
10
Chemistry
Undergraduate 4
03/26/2010

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Cards

Term
Hazard
Definition
capability of a substance to cause an adverse effect
Term
Risk
Definition
the probability that a hazard will occur under specific exposure conditions.
Term
SAR
Definition
Structure/Activity Relationships - theoretical models that can be used to predict the physicochemical, biological and environmental fate properties of molecules.
Term
Necrosis
Definition
The death of a cell caused by a progressive failure of essential metabolic and structural cell components, usually in the cytoplasm.
Term
Apoptosis
Definition
Individual or single cell death by a process of self-destruction of the cell nucleus.
Term
Toxicokinetics
Definition
The study of the time-dependent processes related to toxicants as the interact with living organism.
Term
Cytochrome P450 Reductase
Definition
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Term
Phase II Enzyme Ractions
Definition

Glucuronidation - Look for (COO-) - UDP-GA

Sulfation/(Sulfonation) - SO3 - PAPS

Acetylation - CH3-C=0 - Acetyl coenzyme A

Methylation - CH3 - SAM

Term
Perfusion-Limited Compartments
Definition
Occurs when the cell membrane permeability is much greater than the blood flow rate.
Term
Diffusion-Limited Compartments
Definition
occurs when the flux or transportation of xenobiotics across the cell membrane is slow compared with blood flow.
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