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Thyroid and Bone
Test 4
11
Pharmacology
Professional
04/22/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Levothyroxine
Definition

Synthetic T4 used for thyroid hormone replacement therapy

With myxedema coma, use loading dose

Also used to suppress TSH with pit adenoma

Term
Propylthiouracil
Definition

Inhibits organification of iodide (inhibits thyroid peroxidase) and prevents peripheral conversion of T4 to T3

-preferred in pregnancy

*Agranulocytosis, goiter

Term
Methimazole
Definition

Prevents organification of iodine (inhibits thryroid peroxidase)

-contraindicated in pregnancy (birth defects)

*Agranulocytosis, goiter

Term
Radio-Iodine 131
Definition

Tx of hyperthyroidism

accumulates in follicular cells and selectively destroys thyroid gland

*dont use in pregnancy

Term
Stable Iodide 127
Definition

Give prior to surgery because high levels of iodid inhibit thyroid hormone synth

-rapid onset of actions

-reduces size and vascularity of thyroid

Term
B-Blockers
Definition
when used in hyperthyroidism, inhibit peripheral T4 to T3 conversion
Term
Calcitriol (1,25 Vit D)
Definition

Increases phos and Ca absorption in the kidney by increasing expression of a Ca uptake pump, calbinding protein, and an ATP dependent pump puts into capillaries

*PTH increases production of Calcitriol

Term
Alendronate
Definition

Bisphosphanate- decreases osteoclast activity

*dont give with hypoCa

*must be able to stand upright and eat a meal

Once a year dosing

Term
Etindronate
Definition

Bisphosphanate-

Inhibits mineralization, increases risk of fracture

Term
Calcitonin
Definition

Anti-bone resorptive agent

-binds to receptors on osteoclasts, prevents bone resorption

*shouldn't be used with fish allergies

Term
Calcium Gluconate
Definition
A calcium that can be given IV, less irritating to veins
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