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Thrombolytic Drugs
Review of Thrombolytic Drugs
6
Pharmacology
Undergraduate 1
03/16/2010

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Term
Name 3 Thrombolytic Drugs
Definition
-Streptokinase
-Urokinase
-Alteplase
Term
What is the mechanism of action of Thrombolytics?
Definition
They activate the fibrinolytic system. Plasminogen is converted into plasmin which degrades the fibrin networks of a clot.
Term
What are Thrombolytics used for (4)?
Definition
-Dissolve existing clots after they have formed
-After heart attack to prevent prolonged myocardial ischemia
-In medical emergencies to treat MI (myocardial infarction), PE (pulmonary embolism), arterial occlusions, and DVT (deep vein thrombosis)
-To restore potency to occluded central venous catheters
Term
ADRs of Thrombolytics (4)
Definition
-Bleeding
-Hypersensitivity reactions
-Nausea
-Vomiting
Term
What are the nursing considerations when administering Thrombolytics (4)?
Definition
-Contraindications
-Cardiac monitoring
-Monitor vital signs
-Patient education
Term
Name the antidote to Thrombolytics.
Definition
Aminocaproic acid
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