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Steps of the Crossbridge Cycle
N/A
5
Physiology
Undergraduate 2
11/18/2013

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Term
Step 1: Binding of myosin to actin
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Definition
ADP and Pi are bound to ATPase site of myosin head. Creates high affinity for actin and the myosin head binds to thin filament
Term
Step 2: Power Stroke
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Definition
Myosin head pivots and pulls thin filament toward the M-line
Term
Step 3: Rigor
Definition
ADP released from myosin head and myosin goes into low-energy form tightly bounding itself to actin.
Term

Step 4: Unbinding of Myosin and Actin

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Definition
ATP enters the ATPase site on myosin head triggering a conformational change, decreasing myosin's affinity for actin and detaching myosin from actin.
Term

Step 5: Cocking of the Myosin Head

[image]

Definition
ATP is split by hydrolysis releasing energy which is captured by the myosin molecule and it returns to its high-energy conformation. ADP and Pi remain bound to ATPase site.
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