Shared Flashcard Set

Details

Stem Cell Therapies
Exam 2
17
Pharmacology
Professional
03/05/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
renewal
Definition
unspecialized cells capable of renewing them-selves through cell division after long period of inactivity
Term
differentiation
Definition
under certain physiologic or experimental conditions they can be induced to become tissue-or-organ-specific cells with special functions
Term
embryonic stem cells (ES)
Definition
derived from pre-implantation or peri-implantation embryos; PLURIpotent, self-renew in culture, differentiate into ectoderm, mesoderm and endoderm cells in vivo
Term
Hematopoetic stem cells (HSCs)
Definition
self-renew in bone marrow and produce entire blood system
Term
"stemness" characteristics
Definition
sense a broad range of growth factors and signaling molecules, express genes that are involved in regulating cell cycle and quiescence, can express downstream signaling components to respond to these signals
Term
zygote
Definition
totipotent
Term
totipotent
Definition
ability of a single cell to divide and produce all the differentiated cells in an organism including extra-embryonic tissues
Term
ES cells (potency)
Definition
pluripotent
Term
pluripotent
Definition
stem cell that has the potential to differentiate into any of the three germ layers (endoderm, mesoderm, ectoderm)
Term
HSC (potency)
Definition
multipotent
Term
multipotency
Definition
have the potential to give rise to cells from multiple lineages
Term
hematopoietic progenitors
Definition
also called colony forming units that have limited self-renewal and differentiation; unipotent (CFU-E) and oligopotent (CFU-GM)
Term
E Donnall Thomas
Definition
HSC transplant
Term
allogenic
Definition
different host and recipient, requires a matched donor can have severe side effects (GVHD and transplant rejection)
Term
autologous
Definition
same donor/ recipient
Term
imperfect markers for human HSCs
Definition
CD34, CD133, and Rho
Term
enritchment of human HSCs (cannot purify)
Definition
CD34 antibody-based magnetic enritchment
Supporting users have an ad free experience!