Shared Flashcard Set

Details

SLE
Lecture 10
14
Pharmacology
Professional
09/03/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
What is the epidemiology of lupus?
Definition
More women than men, less caucasians, usually develops between 20 and 45.
Term
What are the types of lupus?
Definition
Systemic - most common. Autoantibodies (IgG) due to a trigger
Drug induced - hydralazine, procainamide, quinidine, isoniazide, methyldopa
Discoid - skin rash only, in 20% of SLE patients. crusty patches on sun exposed areas.
Overlap - SLE + RA
Term
What are triggers for lupus?
Definition
Stress, UVB, burns/infection, pregnancy, drugs.
NOT viral.
Low C3/C4 in the complement may indicate active lupus - TEST!
Term
What is the most common test for lupus?
Definition
Test for ANA antibodies - antibodies that bind to and destroy the nucleus.
Term
What is antiphospholipid syndrome?
Definition
In 20% of patients, antibodies to phospholipids cause a narrowing of BVs, leads to clots.
Term
How is lupus clinically presented?
Definition
Fever, fatigue, muscle pain.
Dermatological rash - light sensitive. Butterfly rash
Can flare and go into remission
High ANA titers, decreased complement. CBC: low HGb, patelets
Term
What are non-pharmacologic treatments for SLE?
Definition
- Rest
-Exercise
- Smoking avoidance
- Limit UV exposure
Term
How are NSAIDs used for SLE?
Definition
First line for pain
Term
How are antimalarials used for SLE?
Definition
Hydroxychloroquine - first line. Good for rash and pain, maintains remission. Need eye exams q6mo. Safe in pregnancy
Decreases T cell activation, PG formation, stabilizes lysosomes
Term
How are steroids used for SLE?
Definition
Serious, life-threatening SLE.
Lots of AEs. Can use medrol IV or prednisone orally
Term
How is Cyclophosphamide/Cytoxan used for SLE?
Definition
for moderate-severe cases, inhibits DNA in T/B cells. Must adjust for renal function. Monitor immunosuppression, urinary cystitis/cancer (PO more than IV)
Term
What is AZA used for?
Definition
Resistand discoid lupus
Can cause GI effects, leukopenia
Term
What is cellcept used for in SLE?
Definition
Renal and non-renal symptoms, well tolerated
Term
What is Benlysta used for?
Definition
A new treatment that blocks B cell activation. High risk of infection. Ineffective in african americans.
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