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SABS
Pharmacokinetics
19
Pharmacology
Professional
11/28/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Mechanism of Action (MOA)
Definition
The manner in which molecular targets are affected by the drug (How does the drug work?)
Term
Pharmacological Effects
Definition
The end points of the signal transduction events (What does the drug do?)
Term
Side Effects
Definition
Predictable reactions, some are merely bothersome
Term
Adverse Effects/Adverse Drug Reactions
Definition
Anything that causes the patient to stop taking the drug
Term
Contraindications
Definition
Medications and health conditions that pose considerable risk
Term
4 Major Types of Drug-Receptors
Definition
Ion Channels
G-protein coupled receptor
Transmembrane with enzyme intracellular receptor
Intracellular receptor
Term
Potency
Definition
The concentration at which the drug elicits 50% of its maximal response
Term
Agonist
Definition
Elicits a response from tissue
Term
Full agonist
Definition
The drug with the greatest pharmacological effects
Term
Partial agonist
Definition
Effects are less than full agonist
Term
Inverse agonist
Definition
Causes an effect opposite to that of the agonist
Term
Antagonist
Definition
Prevention of activity of an agonist
Term
Competitive
Definition
Binds at the same site on the receptor as the agonist
Term
Non-competitive
Definition
Binds at a different site than the agonist
Term
Uncompetitive
Definition
Can bind at a different site than the agonist even when the agonist is bound.
Term
Affinity
Definition
Tendency to bind receptors
Term
Efficacy
Definition
The ability to initiate a response
Term
Intrinsic activity
Definition
Capacity of a single drug-receptor complex to evoke a response
Term
Allosteric Model of Drug Action
Definition
Receptors exist in more than one configuration.
Certain percentage are in the active conformation.
Agonist can 'push' the receptors into an active conformation.
Antagonist can 'push' into an inactive conformation.
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