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S3 Ross Path WBC 2
Arya
28
Pathology
Professional
11/11/2009

Additional Pathology Flashcards

 


 

Cards

Term
A malignant neoplastic proliferation of hematopoietic stem cells in bone marrow. Neoplastic cells may appear in the PBS as well.
Definition
Leukemia
Term
Malignant tumors of lymphoid tissue derived from lymphoid cells. Usually a solid tumor in a lymph node. Might appear in blood.
Definition
Lymphoma
Term
Polycythemia vera, Essential thrombocythemia, CML are all
Definition
Myeloproliferative disorders (MPD)
Term
Abnormal proliferation and maturation of WBCs. Leads to pancytopenia.
Definition
MyeloDISPLASTIC Syndrome (MDS)
Term
Uncontrolled proliferation of histiocytes and dendritic cells.
Definition
Histiocytosis
Term
Patient arrives fatigued and has thrombocytopenia (bleeding problems).PBS shows blasts (immature cells).
Definition
Leukemia
Term
Blast count is less than 20%.
Definition
Chronic leukemia. If Blast count if over 20%, then it could be acute leukemia.
Term
Sternal tenderness
Definition
Acute leukemia.
Term
Myeloid vs. Lymphoid leukemia
Definition
ALL = kids. AML = 15-30. CLL over 60
Term
Auer Rods are fused lysosomes see in...
Definition
Term
Infiltrates into tissues
Definition
AML M5
Term
Hypercellular bone marrow with loss of adipose tissue.
Definition
Acute leukemia. Can be AML OR ALL
Term
AML PBS shows...
Definition
Linear structures in the cytoplasm are Auer Rods. Seen in leukemic cells.
Term
You need to make an AML diagnosis on BM examination. What specific test will you ask for.
Definition
Myeloperodidase/SBB stain shows auer rods.
Term
All cells are arrested at the myeloblast stage.
Definition
Acute myelogenous leukemia.
Term
AML M3
Definition
Acute promyelocytic leukemia. t(15,17). Tx is All-trans-retinoic acid.
Term
AML M4 (gum bleeding/hypertrophy)
Definition
Acute myelomonocytic leukemia
Term
AML M5 (gum bleeding/hypertrophy)
Definition
Acute monocytic leukemia
Term
CD13 and CD33 positive
Definition
AML diagnosis markers. Also looks for MPO and SBB stain.
Term
Cough, splenomegaly, thrombocytopenia, high WBCs
Definition
AML
Term
Faggot cells, DIC, 35-40 years of age
Definition
AML M3: acute promyelocytic leukemia.

LOOKS FOR D-DIMERS INSTEAD OF DIC EXPLICITLY STATED!
Term
Promyelocytes with multiple auer rods
Definition
Faggot cells
Term
Why does AML M3 pts get DIC?
Definition
Promyelocytes contain procoagulants which if spilled leads to coagulation.
Term
With t(15/17), why would you see schistocytes?
Definition
Not sure yet...look it up
Term
Gum infiltration. MPO negative. Non-specific esterase positive. Pt is a kid. CD14 positive.
Definition
AML M5: acute monocytic leukemia
Term
What better? (AML 8,21) or?........................
Definition
Term
Kids, PAS with pink color, positive for TdT
Definition
ALL
Term
ALL with more B cell lineage is better or worse than T cell ALL?
Definition
B cell lineage has a better prognosis.
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