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Details

S3.M2.Pharm1,2
Autocoids 1 & 2
5
Pharmacology
Professional
06/10/2010

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Cards

Term
H1 receptor effects
Definition
SMOOTH MUSCLE, endothelium-->Activates the IP3/DAG
Term
H2 receptor effects
Definition
GASTRIC MUCOSA, cardiac muscle, mast cells
Term
what CELL TYPES are involved in the TRIPLE RESPONSE?
Definition
-Microcirculation vessel smooth muscle cells
-Capillary/venular endothelium
-Sensory neurons
Term
clinical uses/general effects of H1 ANTAGONISTS?
Definition
TRADITIONAL ANTIHISTAMINES--> prevention, treatment of allergic rxn, motion sickness, mastocytosis:
-Strong inhibition of edema formation and itching
-Partial inhibition of histamine-induced hypotension
-Strong antinausea and antiemetic actions
-Strong inhibition of bronchiolar and GI smooth muscle contraction
Term
clinical uses/general effects of H2 ANTAGONISTS?
Definition
Used to treat peptic ulcer disease--> GERD, peptic ulcer disease:
-Suppresses basal and meal-stimulated gastric acid secretion
-Reduces the volume of gastric secretion and [pepsin]
-Strongly reduces histamine-stimulated gastric acid secretion
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