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Rodents
Vet 214/104
88
Veterinary Medicine
Undergraduate 2
02/01/2015

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Cards

Term
Genus and species of the mouse
Definition
Mus musculus
Term
Outbred mouse stock
Definition
Swiss Webster
CD-1
ICR
Term
Inbred mouse strains
Definition
DBA
BALB/C
New Zealand white or black
C57BL
C3H
Term
What is the oldest inbred mouse strain?
Definition
DBA
Term
What is unique about C57BL mice?
Definition
Prone to idiopathic ulcerative dermatitis
Term
Color of C3H mice
Definition
Agouti
Term
F1 hybrid mice
Definition
B6D2F1
CD2F1
Term
Transgenic mice
Definition
SCID
Nu/nu
Term
Mouse gestation period
Definition
19-21 days
Term
Normal mouse heart rate
Definition
328-780 Bpm
Term
Normal mouse respiratory rate
Definition
90-220 bpm
Term
Mouse life span
Definition
1-3 years
Term
Genus and species of the rat
Definition
Rattus norvegicus
Term
Outbred rat stocks
Definition
Wistar
Spraugue-Dawley
Long Evans
Term
Appearance of Long Evans stock
Definition
Hooded pattern
Term
Inbred rat strains
Definition
Fischer344 (F344)
Lewis
Spontaneously hypertensive (SHR)
Wistar-Kyoto (WKY)
Buffalo (BUF)
Term
Full name of "WKY" rat strain
Definition
Wistar-Kyoto
Term
Full name of "SHR" rat strain
Definition
Spontaneously hypertensive
Term
Use of F344 rat strain in research
Definition
Testicular tumors, leukemia, and retinal degeneration
Term
Use of Wistar-Kyoto rat strain in research
Definition
Control group for SHR
Term
Use of Buffalo rat strain in research
Definition
Hashimoto's Disease (immune mediated thyroid dz)
Term
Genetically-modified rat strains
Definition
Zucker Diabetic Fatty
Athymic nude rat
P53 knockout
RIP-HAT
Frantic
Term
Size of Zucker Diabetic Fatty rat
Definition
400-600 g
Term
Use of P53 knockout rat in research
Definition
Oncology
Term
Use of RIP-HAT rat in research
Definition
Diabetes
Term
Normal rat heart rate
Definition
313-493 Bpm
Term
Normal rat respiration rate
Definition
71-146 bpm
Term
Rat gestation time
Definition
20-22 days
Term
Rat litter size
Definition
7-11
Term
When does cannibalism occur in rats?
Definition
With unhealthy young
Term
What is the milk spot?
Definition
Place on neonate's abdomen where you can see if the belly is full of milk or not
Term
At what age do rats and mice reach sexual maturity?
Definition
~60 days
Term
When does post-partum estrus occur?
Definition
24 hours after parturition
Term
Normal rodent posture
Definition
All four feet on the floor, eyes and ears alert
Term
Signs of stress or pain in rodents
Definition
Decreased food/water intake (= decreased output)
Dehydration (sunken eyes)
Aggression
Self mutilation
Scruffy coat
Term
What is chromodacryorrhea?
Definition
Harderian glands behind the eyes of rats and mice produce red tears
Term
Modes of transmission of hantavirus
Definition
Bites, aerosols, direct contact, ingestion of contaminated food/water
Term
Which diseases does hantavirus cause?
Definition
Hemorrhagic fever with renal syndrome
Hantavirus pulmonary syndrome
Term
What is SDA?
Definition
Sialodacryoadentitis
Term
What are the clinical signs of SDA?
Definition
Keratoconjunctivitis
Cervical/jaw swelling
Term
How is SDA treated?
Definition
Usually resolves on its own, but can treat KCS until then
Term
Family of Sendai virus
Definition
Paramyxoviridea
Term
How is Sendai virus transmitted?
Definition
Aerosol
Term
What is IDIR?
Definition
Infectious diarrhea of infant rats
Term
What kind of disease is IDIR?
Definition
Rotavirus
Term
What are the clinical signs of IDIR?
Definition
Soft, yellow feces or dried feces around anus of rat pups
Term
What is MRM?
Definition
Murine respiratory mycoplasmosis
Term
What causes MRM?
Definition
Mycoplasma pulmonis?
Term
Clinical signs of MRM
Definition
Snuffling, nasal/ocular discharge, head tilt/circling
Term
Cause of Tyzzer's disease
Definition
Clostridium piliforme
Term
Clinical sign of Tyzzer's
Definition
Diarrhea, dehydration, anorexia
Term
In which strain of rat do up to 50% get mammary tumors?
Definition
Sprague-Dawley
Term
Where is the Zymbal's gland?
Definition
By the ear
Term
What is significant about Zymbal's gland tumors?
Definition
Locally invasive but not metastatic
Term
What is CPN?
Definition
Chronic progressive Glomerulonephropathy
Term
What does CPN cause?
Definition
Kidney disease in elderly rats
Term
Causes of ringtail in rats
Definition
High temperature and low humidity
Term
What is ringtail?
Definition
Necrotic constrictions on the tail
Term
What is LCM?
Definition
Lymphocytic choriomeningitis
Term
How is LCM transmitted?
Definition
Aerosol, bite wounds, arthropod vectors
Term
Clinical signs of Sendai virus in mice
Definition
Weight loss, rough hair coat, dyspnea, teeth chattering, conjunctivitis
Term
Mouse diseases caused by Helicobacter
Definition
Hepatitis and colitis
Term
Types of mouse parvovirus
Definition
Mouse parvovirus (MPV)
Mouse minute virus (MMV)
Term
What is MHV?
Definition
Mouse hepatitis virus
Term
What is significant about mouse hepatitis virus?
Definition
Highly contagious coronavirus
One of the most common in resarch
Screened for
Term
What is EDIM?
Definition
Epizootic diarrhea of infant mice
Term
What is PVM?
Definition
Pneumonia virus of mice
Term
What is MNV?
Definition
Murine norovirus
Term
What does MNV cause?
Definition
Encephalitis
Pneumonia
Hepatitis
Term
What is the most common nematode in mice?
Definition
Pinworms
Term
Common genus of mouse pinworms
Definition
Syphacia
Aspiculuris
Term
What is the Whitten effect?
Definition
Females synchronize estrous
Term
What is the Bruce effect?
Definition
Spontaneous abortion of early pregnancies when introduced to a new male
Term
What is the Lee Boot effect?
Definition
Induction of anestrous when no males are present
Term
Restraint methods of rodents
Definition
Scruff
Hot dog hold
Decap-a-cone
Term
What percent of a mouse's weight is blood?
Definition
8% of body weight
Term
What percent of a mouse's total blood volume can be collected in a recovery procedure?
Definition
10% total blood volume
Term
Survivable blood collection methods from mice
Definition
Tail nick
Tail snip
Tail vein
Retro-orbital sinus
Saphenous
Term
Non-survivable blood collection methods from mice
Definition
Intracardiac
Term
How much tail can be removed during a tail snip?
Definition
<5 mm
Term
How to perform a tail nick in a mouse
Definition
Warm the mouse under a lamp
Restrain (tube or anesthesia)
Use #11 blade to nick tail vein
Let blood flow into a tube, do not squeeze/milk tail
Term
How to perform mouse IV injection
Definition
Warm mouse under heat lamp
Restrain in tube/anesthesia
Insert needle halfway down tail, parallel to the vein
DO NOT ASPIRATE!
Inject very slowly - vein will blanch
Term
Maximum intradermal dosage
Definition
50 uL per site
Term
How often can blood be collected from a mouse?
Definition
No more than once every three weeks
Term
How to perform an IC blood draw
Definition
Put under DEEP anesthesia
Insert needle under sternum, pointing cranial and slightly left
Collect up to 1 mL of blood
Term
Rodent analgesia options
Definition
Torb, ketofen, topical analgesics put in surgical wound
Term
Issues with using Avertin
Definition
Must be compounded in-lab
Must be filtered and extremely aseptic
Term
Isoflurane levels for rodent gas anesthesia
Definition
3-4% for induction
1.25-1.75% for maintenance
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