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Repair
Robbins Ch 3 1/23/12
19
Pathology
Professional
01/23/2012

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Term
repair
Definition
the restoration of tissue architecture and function after an injury
Term
1) regeneration
2) healing(scar formation)
Definition
the two ways in which repair occurs
Term
regeneration

(requires intact CT scaffolding)
Definition
the restitution of tissue components identical to those removed or killed(as it was before)

aka growth of tissues and cells to replace lost structures
Term
healing
Definition
the fibroproliferative response that patches, rather than restores a tissue (=fibrosis, fibrous scar)
Term
1)the tissue is intrinsically unable to regenerate(heart)
2)following extensive exudates(organization) ex: inflammatory exudate, pericarditis
3) the underlying CT scaffolding is disrupted/destroyed
Definition
what are the 3 conditions in which fibrosis occurs?
Term
adhesions
Definition
what is the clinical consequence of organization?
Term
1) framework for cell migration
2) maintain cell polarity for reassembly of multilayer structures
3) cells in the ECM are the source of molecules needed for tissue repair
Definition
what is the ECM scaffold used for?
Term
an apoptotic hepatocyte: following acute hepatitis like yellow fever
Definition
what/where is a councilman body?
Term
1) cell proliferation
2) differentiation
3) ECM deposition
Definition
the (3) processes involved in repair
Term
-remnants of injured tissue
-vascular endothelial cells
-fibroblasts
Definition
list some of the cell types that proliferate during tissue repair
Term
repair vs cancer
Definition
physiologic tissue proliferaiton vs pathologic =
Term
cyclins(cyclin D)/cyclin dependent kinases(cdk4)
Definition
name the molecules that regulate the cell cycle
Term
RB (binds to E2F)
also TP53 ('guardian of the genome' increases as DNA mutations increase. Stops cells at G1 checkpoint)
Definition
list the tumor suppressor genes
Term
BAX = apoptosis gene
BCL2 = anti apoptosis gene
Caspases = molecules that carry out apoptosis
Definition
list the apoptosis genes (that are activated when DNA unrepairable)
Term
1) labile (continuously dividing tissues ex: skin/mucosa)
2) quiescent (stable tissues ex: liver)
3) non-dividing (permanant tissues)
Definition
3 groups tissues are divided into based on their proliferative capacity
Term
labile
Definition
the most common forms of cancer arise from ______ tissues
Term
1) epidermis
2) bronchial mucosa
3) oral mucosa
4) cervical mucosa
5) hematopoeitic tissue
Definition
list some labile tissues
Term
stem
Definition
labile cells are derived from the division of ___ cells
Term
stem cells
Definition
labile tissues can readily regenerate after injury as long as the pool of _____ are preserved
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