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Renal Pathology
Assessment 11
52
Pathology
Graduate
01/07/2012

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Cards

Term
Anuria
Definition
no urine formation
Term
Bacteriuria
Definition
bacteria in the urine
Term
Bence-Jones protein
Definition
proteins found in the urine of patients with multiple myeloma, consisting of monoclonal immunoglobulins
Term
Cast
Definition
mold of the tubule of a nephron formed by hyaline, RBCs, WBCs, or a combinations and excreted in the urine
Term
Dysuria
Definition
difficulty or pain with urination
Term
Glomerulonephritis
Definition
diffuse inflammatory changes in glomeruli that are not the acute response to infection of the kidney
Term
Hematuria
Definition
blood in the urine
Term
Hepatorenal syndrome
Definition
acute renal failure in pts with liver or biliary disease due to ↓ perfusion of the kidney
Term
Hydronephrosis
Definition
dilation of the pelvis and calyces of one or both kidneys. Can be due to obstruction,
Term
Kimmelstiel-Wilson disease
Definition
nephrotic syndrome and HTN in diabetic pts: glomerulosclerosis
Term
Nephrolithiasis
Definition
presence or renal calculi
Term
Nephrosclerosis
Definition
fibrosis of the kidney by the interstitial connective tissue
Term
Nocturia
Definition
urination at night after waking from sleep
Term
Oliguria
Definition
scant urine production
Term
Proteinuria
Definition
protein in the urine
Term
Pyelonephritis
Definition
inflammation of the renal parenchyma, calyces, and pelvis usually due to bacterial infection
Term
Pyuria
Definition
pus in the urine
Term
Uremia
Definition
excess of urea in the blood (↑ BUN)
Term
Urolithiasis
Definition
calculi in the urinary system
Term
vonHippel-Lindau (VHL) syndrome
Definition
mutation in chromosome 3 causing renal cell carcinoma or hamartomas as part of its syndrome
Term
"wire-loop" lesion
Definition
thickening of the BM with fibrinoid stainingof scattered peripheral capillaries in renal glomeruli. Seen in SLE
Term
nephritic syndrome
Definition
(inflammatory syndrome)acute onset, hematuria, azotemia, oliguria, HTN, proteinuria, and edema
Term
Nephrotic syndrome
Definition
PROTEINURIA, hypoalbuminemia, HL, lipiduria, edema
Term
Minimal change disease
Definition
Most common cause of nephrotic syndrome in children?
Term
Diabetic glomerulosclerosis
Definition
Most common cause of secondary nephrotic syndrome in adults?
Term
membranous glomerulonephritis
Definition
Most common cause of primary nephrotic syndrome in caucasain adults?
Term
FSGS
Definition
Most common cause of primary nephrotic syndrome in AA adults?
Term
Membranoproliferative GN
Definition
EM shows splitting of the GBM?
Term
1. acute proliferative (post infectious)
2. subepithelial
Definition
Hump deposits are associated with __(1)__ glomerulonephritis and are at what layer? (2)
Term
IgA Nephropathy (Berger disease)
Definition
Most common glomerulonephritis worldwide
Term
Hereditary nephritis (Alport Syndrome)
Definition
Alternating lamina rara and densa in the GBM.
Term
Blindness, deafness, and nephritis
Definition
What are the associated symptoms of Alport syndrome?
Term
Cortical adenoma
Definition
What is the most common tumor of the kidney?
Term
1- Oncocytoma
2- benign
Definition
(1)Spoke wheel patter refers to what type of tumor?
(2)Benign or malignant?
Term
Clear cell carcinoma
Definition
What is the most common type of renal cancer?
Term
Autosomal dominant PKD
Definition
Most common PKD?
Term
Type I: polycystin I
Type II: polycystin II
Definition
In ADPKD, what mutation is present?
Term
MCKD1 or 2
Definition
What is the mutation present in medullary cystic kidney disease?
Term
Nephronophthisis
Definition
What goes along with retinitis pigmentosa, liver fibrosis, mental retardation, and cerebellar malformations?
Term
Proteinuria >3.5g/day
Definition
What is the primary diagnostic criteria for nephrotic syndrome?
Term
EM: diffuse podocyte effacement, lipid droplets in PT.
LM: nothing
Definition
What does EM of minimal change disease show? LM?
Term
EM: thickening of GBM, podocyte effacement, and subepithelial deposits
LM: spikes on silver stain
IF: granular, discontinuous pattern
Definition
What does EM show with membranous GN? LM? IF?
Term
EM: subendothelial deposits (complement and IgG), podocyte effacement, and split GBM
IF: granular deposits
LM: thickening of the GBM and increased cellularity.
Definition
What does EM show with membranoproliferative GN type I? LM? IF?
Term
EM: subendothelial deposits (C3 only), podocyte effacement, and split GBM
IF: granular deposits
LM: thickening of the GBM and increased cellularity.
Definition
What does EM show with membranoproliferative GN type II? LM? IF?
Term
EM: subepithelial deposits
IF: granular deposits of IgG and complement
LM: closed capillary loops with PMNS and monocytes, possibly crescents
Definition
What does EM show with postinfectious GN? LM? IF?
Term
immunologic glomerular injury (Wegner's, microscopic polyangitis).
Definition
What usually causes rapidly progressive glomerulonephritis?
Term
LM: crescents, fibrin, necrosis
IF: linear deposits unless ANCA associated vasculitis
Definition
What does LM show with rapidly progressive GN? IF?
Term
IgA nephropathy (Berger)
Definition
What GN often follows URI or GI infections?
Term
Alport syndrome (hereditary nephritis)
Definition
What renal disease is associated with blindness and deafness?
Term
chronic pyelonephritis
Definition
Thyroidization of the kidney is seen in what disease?
Term
drug-induced interstitial nephritis
Definition
What renal disease shows eosinophilia
Term
interstitial nephritis and papillary necrosis (analgesic nephropathy)
Definition
What renal problem does prolonged use of phenacetin lead to?
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